Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010 |
Resumo: | Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI. |
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Memórias do Instituto Oswaldo Cruz |
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Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agenthuman rhinovirusesco-infectionlower respiratory tractyoung childrenHuman rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI.Instituto Oswaldo Cruz, Ministério da Saúde2011-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010Memórias do Instituto Oswaldo Cruz v.106 n.3 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000300010info:eu-repo/semantics/openAccessPaula,Nayhanne Tizzo deCarneiro,Bruno MoreiraYokosawa,JonnyFreitas,Guilherme Ramos Oliveira eOliveira,Thelma Fátima de MattosCosta,Lourenço FariaSilveira,Hélio Lopes daQueiróz,Divina Aparecida Oliveiraeng2020-04-25T17:50:59Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:17:36.402Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
title |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
spellingShingle |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent Paula,Nayhanne Tizzo de human rhinoviruses co-infection lower respiratory tract young children |
title_short |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
title_full |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
title_fullStr |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
title_full_unstemmed |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
title_sort |
Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent |
author |
Paula,Nayhanne Tizzo de |
author_facet |
Paula,Nayhanne Tizzo de Carneiro,Bruno Moreira Yokosawa,Jonny Freitas,Guilherme Ramos Oliveira e Oliveira,Thelma Fátima de Mattos Costa,Lourenço Faria Silveira,Hélio Lopes da Queiróz,Divina Aparecida Oliveira |
author_role |
author |
author2 |
Carneiro,Bruno Moreira Yokosawa,Jonny Freitas,Guilherme Ramos Oliveira e Oliveira,Thelma Fátima de Mattos Costa,Lourenço Faria Silveira,Hélio Lopes da Queiróz,Divina Aparecida Oliveira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Paula,Nayhanne Tizzo de Carneiro,Bruno Moreira Yokosawa,Jonny Freitas,Guilherme Ramos Oliveira e Oliveira,Thelma Fátima de Mattos Costa,Lourenço Faria Silveira,Hélio Lopes da Queiróz,Divina Aparecida Oliveira |
dc.subject.por.fl_str_mv |
human rhinoviruses co-infection lower respiratory tract young children |
topic |
human rhinoviruses co-infection lower respiratory tract young children |
dc.description.none.fl_txt_mv |
Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI. |
description |
Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762011000300010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.106 n.3 2011 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
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1669937709852917760 |