Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent

Detalhes bibliográficos
Autor(a) principal: Paula,Nayhanne Tizzo de
Data de Publicação: 2011
Outros Autores: Carneiro,Bruno Moreira, Yokosawa,Jonny, Freitas,Guilherme Ramos Oliveira e, Oliveira,Thelma Fátima de Mattos, Costa,Lourenço Faria, Silveira,Hélio Lopes da, Queiróz,Divina Aparecida Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010
Resumo: Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI.
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spelling Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agenthuman rhinovirusesco-infectionlower respiratory tractyoung childrenHuman rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI.Instituto Oswaldo Cruz, Ministério da Saúde2011-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010Memórias do Instituto Oswaldo Cruz v.106 n.3 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000300010info:eu-repo/semantics/openAccessPaula,Nayhanne Tizzo deCarneiro,Bruno MoreiraYokosawa,JonnyFreitas,Guilherme Ramos Oliveira eOliveira,Thelma Fátima de MattosCosta,Lourenço FariaSilveira,Hélio Lopes daQueiróz,Divina Aparecida Oliveiraeng2020-04-25T17:50:59Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:17:36.402Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
title Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
spellingShingle Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
Paula,Nayhanne Tizzo de
human rhinoviruses
co-infection
lower respiratory tract
young children
title_short Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
title_full Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
title_fullStr Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
title_full_unstemmed Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
title_sort Human rhinovirus in the lower respiratory tract infections of young children and the possible involvement of a secondary respiratory viral agent
author Paula,Nayhanne Tizzo de
author_facet Paula,Nayhanne Tizzo de
Carneiro,Bruno Moreira
Yokosawa,Jonny
Freitas,Guilherme Ramos Oliveira e
Oliveira,Thelma Fátima de Mattos
Costa,Lourenço Faria
Silveira,Hélio Lopes da
Queiróz,Divina Aparecida Oliveira
author_role author
author2 Carneiro,Bruno Moreira
Yokosawa,Jonny
Freitas,Guilherme Ramos Oliveira e
Oliveira,Thelma Fátima de Mattos
Costa,Lourenço Faria
Silveira,Hélio Lopes da
Queiróz,Divina Aparecida Oliveira
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paula,Nayhanne Tizzo de
Carneiro,Bruno Moreira
Yokosawa,Jonny
Freitas,Guilherme Ramos Oliveira e
Oliveira,Thelma Fátima de Mattos
Costa,Lourenço Faria
Silveira,Hélio Lopes da
Queiróz,Divina Aparecida Oliveira
dc.subject.por.fl_str_mv human rhinoviruses
co-infection
lower respiratory tract
young children
topic human rhinoviruses
co-infection
lower respiratory tract
young children
dc.description.none.fl_txt_mv Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI.
description Human rhinoviruses (HRV) are usually associated with mild respiratory symptoms in children. However, some studies have found that HRV can cause severe disease, especially when the patient is co-infected with a second virus. In this study, 532 nasopharyngeal aspirates (NPAs) were collected over a nine-year period from children at the Clinics Hospital of Uberlândia. The collected NPAs were then tested for HRV RNA using the reverse transcription-polymerase chain reaction. Eighty-three specimens from children diagnosed with lower respiratory tract illness (LRTI) were positive for HRV RNA and were then tested for the presence of eight other respiratory viruses. A second virus was detected in 37.3% (31/83) of the samples. The most frequent clinical diagnosis was bronchiolitis, followed by other LRTI and then pneumonia. The frequency of severe disease in children infected with more than one virus was not significantly different from the frequency of severe disease in children infected with HRV alone. Children infected with both HRV and parainfluenza virus (1.5 m.o.) were significantly younger than those infected by HRV alone (5.0 m.o.) (p = 0.0454). Overall, these results suggest that infection with a second virus does not lead to a higher frequency of severe syndromes in children presenting with LRTI.
publishDate 2011
dc.date.none.fl_str_mv 2011-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762011000300010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.106 n.3 2011
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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