Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys

Detalhes bibliográficos
Autor(a) principal: Freire,MS
Data de Publicação: 2007
Outros Autores: Marchevsky,RS, Almeida,LFC, Yamamura,AMY, Caride,EC, Brindeiro,PA, Motta,MCA, Nogueira,RMR, Kubelka,CF, Bonaldo,MC, Galler,R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000200013
Resumo: Among the flaviviruses, dengue, with its four serotypes, has spread throughout the tropics. The most advanced vaccines developed so far include live attenuated viruses, which have been tested in humans but none has been licensed. Preclinical testing of dengue vaccine candidates is performed initially in mice and in nonhuman primates. In the latter the main criteria used to assay protection are neutralizing antibodies elicited by the vaccine candidate and the magnitude and duration of peripheral viremia upon challenge of previously immunized animals. Towards the identification of wild-type viruses that could be used in challenge experiments a total of 31 rhesus monkeys were inoculated subcutaneously of wild dengue types 1, 2, and 3 viruses. The viremia caused by the different viruses was variable but it was possible to identify dengue viruses useful as challenge strains.
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spelling Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeysflavivirusesdengue virusinfectivityrhesus monkeysAmong the flaviviruses, dengue, with its four serotypes, has spread throughout the tropics. The most advanced vaccines developed so far include live attenuated viruses, which have been tested in humans but none has been licensed. Preclinical testing of dengue vaccine candidates is performed initially in mice and in nonhuman primates. In the latter the main criteria used to assay protection are neutralizing antibodies elicited by the vaccine candidate and the magnitude and duration of peripheral viremia upon challenge of previously immunized animals. Towards the identification of wild-type viruses that could be used in challenge experiments a total of 31 rhesus monkeys were inoculated subcutaneously of wild dengue types 1, 2, and 3 viruses. The viremia caused by the different viruses was variable but it was possible to identify dengue viruses useful as challenge strains.Instituto Oswaldo Cruz, Ministério da Saúde2007-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000200013Memórias do Instituto Oswaldo Cruz v.102 n.2 2007reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762007005000011info:eu-repo/semantics/openAccessFreire,MSMarchevsky,RSAlmeida,LFCYamamura,AMYCaride,ECBrindeiro,PAMotta,MCANogueira,RMRKubelka,CFBonaldo,MCGaller,Reng2020-04-25T17:50:06Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:15:03.256Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
title Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
spellingShingle Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
Freire,MS
flaviviruses
dengue virus
infectivity
rhesus monkeys
title_short Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
title_full Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
title_fullStr Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
title_full_unstemmed Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
title_sort Wild dengue virus types 1, 2 and 3 viremia in rhesus monkeys
author Freire,MS
author_facet Freire,MS
Marchevsky,RS
Almeida,LFC
Yamamura,AMY
Caride,EC
Brindeiro,PA
Motta,MCA
Nogueira,RMR
Kubelka,CF
Bonaldo,MC
Galler,R
author_role author
author2 Marchevsky,RS
Almeida,LFC
Yamamura,AMY
Caride,EC
Brindeiro,PA
Motta,MCA
Nogueira,RMR
Kubelka,CF
Bonaldo,MC
Galler,R
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freire,MS
Marchevsky,RS
Almeida,LFC
Yamamura,AMY
Caride,EC
Brindeiro,PA
Motta,MCA
Nogueira,RMR
Kubelka,CF
Bonaldo,MC
Galler,R
dc.subject.por.fl_str_mv flaviviruses
dengue virus
infectivity
rhesus monkeys
topic flaviviruses
dengue virus
infectivity
rhesus monkeys
dc.description.none.fl_txt_mv Among the flaviviruses, dengue, with its four serotypes, has spread throughout the tropics. The most advanced vaccines developed so far include live attenuated viruses, which have been tested in humans but none has been licensed. Preclinical testing of dengue vaccine candidates is performed initially in mice and in nonhuman primates. In the latter the main criteria used to assay protection are neutralizing antibodies elicited by the vaccine candidate and the magnitude and duration of peripheral viremia upon challenge of previously immunized animals. Towards the identification of wild-type viruses that could be used in challenge experiments a total of 31 rhesus monkeys were inoculated subcutaneously of wild dengue types 1, 2, and 3 viruses. The viremia caused by the different viruses was variable but it was possible to identify dengue viruses useful as challenge strains.
description Among the flaviviruses, dengue, with its four serotypes, has spread throughout the tropics. The most advanced vaccines developed so far include live attenuated viruses, which have been tested in humans but none has been licensed. Preclinical testing of dengue vaccine candidates is performed initially in mice and in nonhuman primates. In the latter the main criteria used to assay protection are neutralizing antibodies elicited by the vaccine candidate and the magnitude and duration of peripheral viremia upon challenge of previously immunized animals. Towards the identification of wild-type viruses that could be used in challenge experiments a total of 31 rhesus monkeys were inoculated subcutaneously of wild dengue types 1, 2, and 3 viruses. The viremia caused by the different viruses was variable but it was possible to identify dengue viruses useful as challenge strains.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000200013
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000200013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762007005000011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.102 n.2 2007
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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