Immunogenetic and protective activity of an extract of Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Tendler,M.
Data de Publicação: 1982
Outros Autores: Lima,A. Oliveira, Pinto,R. Magalhães, Cruz,M. Queiroz, Brascher,H. M., Katz,N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000300006
Resumo: The immunogenic and protective activity of an extract of S. mansoni, obtained by incubation of viable adult worms in buffered saline, was evaluated in rabbits and mice. Animal immunization with this extract resulted in the development of both humoral and cellular immune response. All immunized rabbits developed high levels (91 to 100%) of cytotoxic antibodies as determined by in vitro assays of cytotoxic activity of their sera against viable schistosomules. Immunized animals challenged with S. mansoni cercariae showed a lower parasite load than that of normal controls. Protective activity was 88.6% and 54.0% in immunized rabbits and mice, respectively.
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spelling Immunogenetic and protective activity of an extract of Schistosoma mansoniThe immunogenic and protective activity of an extract of S. mansoni, obtained by incubation of viable adult worms in buffered saline, was evaluated in rabbits and mice. Animal immunization with this extract resulted in the development of both humoral and cellular immune response. All immunized rabbits developed high levels (91 to 100%) of cytotoxic antibodies as determined by in vitro assays of cytotoxic activity of their sera against viable schistosomules. Immunized animals challenged with S. mansoni cercariae showed a lower parasite load than that of normal controls. Protective activity was 88.6% and 54.0% in immunized rabbits and mice, respectively.Instituto Oswaldo Cruz, Ministério da Saúde1982-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000300006Memórias do Instituto Oswaldo Cruz v.77 n.3 1982reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761982000300006info:eu-repo/semantics/openAccessTendler,M.Lima,A. OliveiraPinto,R. MagalhãesCruz,M. QueirozBrascher,H. M.Katz,N.eng2020-04-25T17:45:26Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:00:25.206Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Immunogenetic and protective activity of an extract of Schistosoma mansoni
title Immunogenetic and protective activity of an extract of Schistosoma mansoni
spellingShingle Immunogenetic and protective activity of an extract of Schistosoma mansoni
Tendler,M.
title_short Immunogenetic and protective activity of an extract of Schistosoma mansoni
title_full Immunogenetic and protective activity of an extract of Schistosoma mansoni
title_fullStr Immunogenetic and protective activity of an extract of Schistosoma mansoni
title_full_unstemmed Immunogenetic and protective activity of an extract of Schistosoma mansoni
title_sort Immunogenetic and protective activity of an extract of Schistosoma mansoni
author Tendler,M.
author_facet Tendler,M.
Lima,A. Oliveira
Pinto,R. Magalhães
Cruz,M. Queiroz
Brascher,H. M.
Katz,N.
author_role author
author2 Lima,A. Oliveira
Pinto,R. Magalhães
Cruz,M. Queiroz
Brascher,H. M.
Katz,N.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Tendler,M.
Lima,A. Oliveira
Pinto,R. Magalhães
Cruz,M. Queiroz
Brascher,H. M.
Katz,N.
dc.description.none.fl_txt_mv The immunogenic and protective activity of an extract of S. mansoni, obtained by incubation of viable adult worms in buffered saline, was evaluated in rabbits and mice. Animal immunization with this extract resulted in the development of both humoral and cellular immune response. All immunized rabbits developed high levels (91 to 100%) of cytotoxic antibodies as determined by in vitro assays of cytotoxic activity of their sera against viable schistosomules. Immunized animals challenged with S. mansoni cercariae showed a lower parasite load than that of normal controls. Protective activity was 88.6% and 54.0% in immunized rabbits and mice, respectively.
description The immunogenic and protective activity of an extract of S. mansoni, obtained by incubation of viable adult worms in buffered saline, was evaluated in rabbits and mice. Animal immunization with this extract resulted in the development of both humoral and cellular immune response. All immunized rabbits developed high levels (91 to 100%) of cytotoxic antibodies as determined by in vitro assays of cytotoxic activity of their sera against viable schistosomules. Immunized animals challenged with S. mansoni cercariae showed a lower parasite load than that of normal controls. Protective activity was 88.6% and 54.0% in immunized rabbits and mice, respectively.
publishDate 1982
dc.date.none.fl_str_mv 1982-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000300006
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761982000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.77 n.3 1982
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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