Experimental Neuroschistosomiasis: Inadequacy of the Murine Model

Detalhes bibliográficos
Autor(a) principal: Silva,Luciana M
Data de Publicação: 2002
Outros Autores: Oliveira,Carla Neves de, Andrade,Zilton A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000400028
Resumo: Neuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature. Severe, recent and late Schistosoma mansoni infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.
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spelling Experimental Neuroschistosomiasis: Inadequacy of the Murine ModelneuroschistosomiasisSchistosoma mansonimurine modelNeuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature. Severe, recent and late Schistosoma mansoni infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.Instituto Oswaldo Cruz, Ministério da Saúde2002-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000400028Memórias do Instituto Oswaldo Cruz v.97 n.4 2002reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762002000400028info:eu-repo/semantics/openAccessSilva,Luciana MOliveira,Carla Neves deAndrade,Zilton Aeng2020-04-25T17:48:47Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:11:11.356Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
title Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
spellingShingle Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
Silva,Luciana M
neuroschistosomiasis
Schistosoma mansoni
murine model
title_short Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
title_full Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
title_fullStr Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
title_full_unstemmed Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
title_sort Experimental Neuroschistosomiasis: Inadequacy of the Murine Model
author Silva,Luciana M
author_facet Silva,Luciana M
Oliveira,Carla Neves de
Andrade,Zilton A
author_role author
author2 Oliveira,Carla Neves de
Andrade,Zilton A
author2_role author
author
dc.contributor.author.fl_str_mv Silva,Luciana M
Oliveira,Carla Neves de
Andrade,Zilton A
dc.subject.por.fl_str_mv neuroschistosomiasis
Schistosoma mansoni
murine model
topic neuroschistosomiasis
Schistosoma mansoni
murine model
dc.description.none.fl_txt_mv Neuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature. Severe, recent and late Schistosoma mansoni infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.
description Neuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature. Severe, recent and late Schistosoma mansoni infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.
publishDate 2002
dc.date.none.fl_str_mv 2002-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000400028
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000400028
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762002000400028
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.97 n.4 2002
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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