On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver

Detalhes bibliográficos
Autor(a) principal: Lopez de O.,Aura
Data de Publicação: 1993
Outros Autores: Carmona de G.,C. A., Moussatche,H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200023
Resumo: In this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity.
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spelling On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty livercold acclimatizationhepatic lipoprotein lipasefatty livercarbon tetrachlorideethionineIn this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity.Instituto Oswaldo Cruz, Ministério da Saúde1993-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200023Memórias do Instituto Oswaldo Cruz v.88 n.2 1993reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761993000200023info:eu-repo/semantics/openAccessLopez de O.,AuraCarmona de G.,C. A.Moussatche,H.eng2020-04-25T17:47:09Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:05:40.053Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
title On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
spellingShingle On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
Lopez de O.,Aura
cold acclimatization
hepatic lipoprotein lipase
fatty liver
carbon tetrachloride
ethionine
title_short On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
title_full On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
title_fullStr On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
title_full_unstemmed On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
title_sort On the mechanism of protective action of cold acclimatization against carbon tetrachloride - and ethionine-induced fatty liver
author Lopez de O.,Aura
author_facet Lopez de O.,Aura
Carmona de G.,C. A.
Moussatche,H.
author_role author
author2 Carmona de G.,C. A.
Moussatche,H.
author2_role author
author
dc.contributor.author.fl_str_mv Lopez de O.,Aura
Carmona de G.,C. A.
Moussatche,H.
dc.subject.por.fl_str_mv cold acclimatization
hepatic lipoprotein lipase
fatty liver
carbon tetrachloride
ethionine
topic cold acclimatization
hepatic lipoprotein lipase
fatty liver
carbon tetrachloride
ethionine
dc.description.none.fl_txt_mv In this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity.
description In this study the hepatic lipoprotein lipase (LPL), activity was evaluated in adult female mice acclimatized at 5-C and submitted to carbon tetrachloride (CCI) or ethionine, in order to determine the possible role of this enzuyme in the fatty liver. The results were compared with those obtained in mice kept at room temperature (27-C) that the same hepatoesteatosis inducing agent. In contrast to animals kept at room temperature, in cold aclimatized mice neither the enhancement of the LPL-liver activity by the action of CCI or ethionine occurred nor the development of fatty infiltration in the liver was observed. We conclude that the low temperature induced a protective effect against CCI or ethionine-induced fatty liver that was correlated with the no-increase of the hepatic LPL activity.
publishDate 1993
dc.date.none.fl_str_mv 1993-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200023
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000200023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761993000200023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.88 n.2 1993
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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