Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Memórias do Instituto Oswaldo Cruz |
| Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600007 |
Resumo: | The primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 1:20 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads. |
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Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studiesToxoplasma gondiicat enteric cycle of T. gondiiintestinal epithelial cellsprimary culture of enterocytesThe primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 1:20 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads.Instituto Oswaldo Cruz, Ministério da Saúde2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600007Memórias do Instituto Oswaldo Cruz v.104 n.6 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000600007info:eu-repo/semantics/openAccessMoura,Marcos de AssisAmendoeira,Maria Regina ReisBarbosa,Helene Santoseng2020-04-25T17:50:32Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:24.627Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
| dc.title.none.fl_str_mv |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies |
| title |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies |
| spellingShingle |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies Moura,Marcos de Assis Toxoplasma gondii cat enteric cycle of T. gondii intestinal epithelial cells primary culture of enterocytes |
| title_short |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies |
| title_full |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies |
| title_fullStr |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies |
| title_full_unstemmed |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies |
| title_sort |
Primary culture of intestinal epithelial cells as a potential model for Toxoplasma gondii enteric cycle studies |
| author |
Moura,Marcos de Assis |
| author_facet |
Moura,Marcos de Assis Amendoeira,Maria Regina Reis Barbosa,Helene Santos |
| author_role |
author |
| author2 |
Amendoeira,Maria Regina Reis Barbosa,Helene Santos |
| author2_role |
author author |
| dc.contributor.author.fl_str_mv |
Moura,Marcos de Assis Amendoeira,Maria Regina Reis Barbosa,Helene Santos |
| dc.subject.por.fl_str_mv |
Toxoplasma gondii cat enteric cycle of T. gondii intestinal epithelial cells primary culture of enterocytes |
| topic |
Toxoplasma gondii cat enteric cycle of T. gondii intestinal epithelial cells primary culture of enterocytes |
| dc.description.none.fl_txt_mv |
The primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 1:20 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads. |
| description |
The primary culture of intestinal epithelial cells from domestic cats is an efficient cellular model to study the enteric cycle of Toxoplasma gondii in a definitive host. The parasite-host cell ratio can be pointed out as a decisive factor that determines the intracellular fate of bradyzoites forms. The development of the syncytial-like forms of T. gondii was observed using the 1:20 bradyzoite-host cell ratio, resulting in similar forms described in in vivo systems. This alternative study potentially opens up the field for investigation into the molecular aspects of this interaction. This can contribute to the development of new strategies for intervention of a main route by which toxoplasmosis spreads. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009-09-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600007 |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600007 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1590/S0074-02762009000600007 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
| publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
| dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.104 n.6 2009 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
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Memórias do Instituto Oswaldo Cruz |
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Memórias do Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz |
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FIOCRUZ |
| institution |
FIOCRUZ |
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Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
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1669937705560047616 |