Molecular epidemiology of HIV-1 clades in Southern Brazil

• Autor(a) principal: Raboni,Sonia Mara
• Data de Publicação: 2010
• Outros Autores: Almeida,Sérgio Monteiro de, Rotta,Indianara, Ribeiro,Cléa Elisa Lopes, Rosario,Debra, Vidal,Luine Rosele, Nogueira,Meri Bordignon, Riedel,Maristela, Winhescki,Maria da Graça, Ferreira,Kátia Antunes, Ellis,Ronald
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Memórias do Instituto Oswaldo Cruz
• Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000800015
• topic: HIV; subtypes; genetic variability; HIV exposure

Human immunodeficiency virus (HIV) clades B and C account for more than 60% of the HIV-1 infections worldwide. In this paper, we describe the profiles of patients infected with subtypes of HIV-1 from the state of Paraná, Southern Brazil, and correlate them with demographic and epidemiological findings. A retrospective analysis of HIV cases reported from 1999-2007 was also performed. Data from 293 patients were reviewed and 245 were older than 13 (58% female). The distribution of clades was as follows: B 140 (57%), C 67 (23%), F 24 (10%) and mosaic or unique recombinant forms (URFs) 24 (10%). Of the 48 patients younger than 13 years of age (62.5% male), vertical transmission occurred in 46 and the distribution of clades was as follows: B 14 (29%), C 24 (50%), F 7 (15%) and URFs 6 (13%). There was no significant difference in mortality between HIV-1 subtypes. In both groups, patients infected with clade C tended to have higher rates of injection drug use exposure risk.