In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi

Detalhes bibliográficos
Autor(a) principal: Herrera,Cristina
Data de Publicação: 2009
Outros Autores: Vallejos,Gabriel A, Loaiza,Randall, Zeledón,Rodrigo, Urbina,Andrea, Sepúlveda-Boza,Silvia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700007
Resumo: The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the compound N1 had the highest level of activity (IC50: 0.6 μM) against epimastigotes.
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spelling In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruziTrypanosoma cruzithienyl-2-nitropropene compoundsChagas diseaseantitrypanosomal activityThe in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the compound N1 had the highest level of activity (IC50: 0.6 μM) against epimastigotes.Instituto Oswaldo Cruz, Ministério da Saúde2009-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700007Memórias do Instituto Oswaldo Cruz v.104 n.7 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000700007info:eu-repo/semantics/openAccessHerrera,CristinaVallejos,Gabriel ALoaiza,RandallZeledón,RodrigoUrbina,AndreaSepúlveda-Boza,Silviaeng2020-04-25T17:50:32Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:28.808Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
title In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
spellingShingle In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
Herrera,Cristina
Trypanosoma cruzi
thienyl-2-nitropropene compounds
Chagas disease
antitrypanosomal activity
title_short In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
title_full In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
title_fullStr In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
title_full_unstemmed In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
title_sort In vitro activity of thienyl-2-nitropropene compounds against Trypanosoma cruzi
author Herrera,Cristina
author_facet Herrera,Cristina
Vallejos,Gabriel A
Loaiza,Randall
Zeledón,Rodrigo
Urbina,Andrea
Sepúlveda-Boza,Silvia
author_role author
author2 Vallejos,Gabriel A
Loaiza,Randall
Zeledón,Rodrigo
Urbina,Andrea
Sepúlveda-Boza,Silvia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Herrera,Cristina
Vallejos,Gabriel A
Loaiza,Randall
Zeledón,Rodrigo
Urbina,Andrea
Sepúlveda-Boza,Silvia
dc.subject.por.fl_str_mv Trypanosoma cruzi
thienyl-2-nitropropene compounds
Chagas disease
antitrypanosomal activity
topic Trypanosoma cruzi
thienyl-2-nitropropene compounds
Chagas disease
antitrypanosomal activity
dc.description.none.fl_txt_mv The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the compound N1 had the highest level of activity (IC50: 0.6 μM) against epimastigotes.
description The in vitro activity of four 2-nitropropene derivatives, 1-(3-benzothienyl)-2-nitropropene (N1), 1-(3-thienyl)-2-nitropropene (N2), 1-(5-bromo-2-thienyl)-2-nitropropene (N3) and 1-(4-bromo-2-thienyl)-2-nitropropene (N4), were tested against cultures of the parasite Trypanosoma cruzi. Cytotoxicity studies were performed using Vero cells. The blood trypomastigotes, amastigotes and epimastigotes showed differential degrees of sensitivity towards the four tested compounds; the highest activity against the epimastigotes and blood tripomastigotes was exhibited by N1, followed by N3, N4 and finally N2. In contrast, whereas the compounds N1, N3 and N4 exerted similar magnitudes of activity against amastigotes, N2 was found to be a much less potent compound. According to our results, the compound N1 had the highest level of activity (IC50: 0.6 μM) against epimastigotes.
publishDate 2009
dc.date.none.fl_str_mv 2009-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700007
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000700007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762009000700007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.104 n.7 2009
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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