Vascular dysfunction as a target for adjuvant therapy in cerebral malaria

Detalhes bibliográficos
Autor(a) principal: Carvalho,Leonardo José de Moura
Data de Publicação: 2014
Outros Autores: Moreira,Aline da Silva, Daniel-Ribeiro,Cláudio Tadeu, Martins,Yuri Chaves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500577
Resumo: Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.
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spelling Vascular dysfunction as a target for adjuvant therapy in cerebral malariacerebral malariavascular dysfunctionnitric oxideCerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.Instituto Oswaldo Cruz, Ministério da Saúde2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500577Memórias do Instituto Oswaldo Cruz v.109 n.5 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276140061info:eu-repo/semantics/openAccessCarvalho,Leonardo José de MouraMoreira,Aline da SilvaDaniel-Ribeiro,Cláudio TadeuMartins,Yuri Chaveseng2020-04-25T17:51:46Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:44.365Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
title Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
spellingShingle Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
Carvalho,Leonardo José de Moura
cerebral malaria
vascular dysfunction
nitric oxide
title_short Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
title_full Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
title_fullStr Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
title_full_unstemmed Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
title_sort Vascular dysfunction as a target for adjuvant therapy in cerebral malaria
author Carvalho,Leonardo José de Moura
author_facet Carvalho,Leonardo José de Moura
Moreira,Aline da Silva
Daniel-Ribeiro,Cláudio Tadeu
Martins,Yuri Chaves
author_role author
author2 Moreira,Aline da Silva
Daniel-Ribeiro,Cláudio Tadeu
Martins,Yuri Chaves
author2_role author
author
author
dc.contributor.author.fl_str_mv Carvalho,Leonardo José de Moura
Moreira,Aline da Silva
Daniel-Ribeiro,Cláudio Tadeu
Martins,Yuri Chaves
dc.subject.por.fl_str_mv cerebral malaria
vascular dysfunction
nitric oxide
topic cerebral malaria
vascular dysfunction
nitric oxide
dc.description.none.fl_txt_mv Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.
description Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500577
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500577
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276140061
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.5 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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