Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200235 |
Resumo: | Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases. |
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Memórias do Instituto Oswaldo Cruz |
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Clinical and epidemiological profiles of individuals with drug-resistant tuberculosistuberculosisdiagnosisantimicrobial resistanceDrug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases.Instituto Oswaldo Cruz, Ministério da Saúde2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200235Memórias do Instituto Oswaldo Cruz v.110 n.2 2015reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-02760140316info:eu-repo/semantics/openAccessPedro,Heloisa da Silveira ParoNardi,Susilene Maria TonelliPereira,Maria Izabel FerreiraOliveira,Rosângela SiqueiraSuffys,Philip NoelGomes,Harrison MagdinierFinardi,Amanda JulianeMoraes,Eloise Brasil deBaptista,Ida Maria Foschiani DiasMachado,Ricardo Luiz DantasCastiglioni,Lilianeng2020-04-25T17:51:58Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:20:18.782Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
title |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
spellingShingle |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis Pedro,Heloisa da Silveira Paro tuberculosis diagnosis antimicrobial resistance |
title_short |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
title_full |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
title_fullStr |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
title_full_unstemmed |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
title_sort |
Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis |
author |
Pedro,Heloisa da Silveira Paro |
author_facet |
Pedro,Heloisa da Silveira Paro Nardi,Susilene Maria Tonelli Pereira,Maria Izabel Ferreira Oliveira,Rosângela Siqueira Suffys,Philip Noel Gomes,Harrison Magdinier Finardi,Amanda Juliane Moraes,Eloise Brasil de Baptista,Ida Maria Foschiani Dias Machado,Ricardo Luiz Dantas Castiglioni,Lilian |
author_role |
author |
author2 |
Nardi,Susilene Maria Tonelli Pereira,Maria Izabel Ferreira Oliveira,Rosângela Siqueira Suffys,Philip Noel Gomes,Harrison Magdinier Finardi,Amanda Juliane Moraes,Eloise Brasil de Baptista,Ida Maria Foschiani Dias Machado,Ricardo Luiz Dantas Castiglioni,Lilian |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pedro,Heloisa da Silveira Paro Nardi,Susilene Maria Tonelli Pereira,Maria Izabel Ferreira Oliveira,Rosângela Siqueira Suffys,Philip Noel Gomes,Harrison Magdinier Finardi,Amanda Juliane Moraes,Eloise Brasil de Baptista,Ida Maria Foschiani Dias Machado,Ricardo Luiz Dantas Castiglioni,Lilian |
dc.subject.por.fl_str_mv |
tuberculosis diagnosis antimicrobial resistance |
topic |
tuberculosis diagnosis antimicrobial resistance |
dc.description.none.fl_txt_mv |
Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases. |
description |
Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200235 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000200235 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0074-02760140316 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.110 n.2 2015 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
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1669937718223699968 |