Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii

Detalhes bibliográficos
Autor(a) principal: Favoreto-Junior,Sílvio
Data de Publicação: 1998
Outros Autores: AV Ferro,Eloísa, Clemente,Diogo, Silva,Deise AO, Mineo,José R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100018
Resumo: Calomys callosus, Rengger 1830 (Rodentia, Cricetidae), a wild rodent found in Central Brazil, was studied to investigate its susceptibility to Toxoplasma gondii experimental infection and its humoral immune response against this protozoa. The electrophoretic profile of the serum proteins of C. callosus showed that IgG, which shows no affinity to Protein A, has higher cross reactivity with rat IgG than with IgG from other rodents. The susceptibility assay was performed by inoculation groups of animals with various suspensions of T. gondii tachyzoites from 102 to 106 parasites. All animals died between 3 and 9 days after infection and the kinetics of antibody synthesis was determined. Basically, they recognized predominantly the immunodominant antigen SAG-1 (P30). The immunohistochemistry assays revealed that the liver was the most heavily infected organ, followed by the spleen, lungs, intestine, brain and kidneys. It can be concluded that C. callosus is an excellent experimental model for acute phase of Toxoplasma infection
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spelling Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondiiToxopasma gondiiCalomys callosusexperimental infectionCalomys callosus, Rengger 1830 (Rodentia, Cricetidae), a wild rodent found in Central Brazil, was studied to investigate its susceptibility to Toxoplasma gondii experimental infection and its humoral immune response against this protozoa. The electrophoretic profile of the serum proteins of C. callosus showed that IgG, which shows no affinity to Protein A, has higher cross reactivity with rat IgG than with IgG from other rodents. The susceptibility assay was performed by inoculation groups of animals with various suspensions of T. gondii tachyzoites from 102 to 106 parasites. All animals died between 3 and 9 days after infection and the kinetics of antibody synthesis was determined. Basically, they recognized predominantly the immunodominant antigen SAG-1 (P30). The immunohistochemistry assays revealed that the liver was the most heavily infected organ, followed by the spleen, lungs, intestine, brain and kidneys. It can be concluded that C. callosus is an excellent experimental model for acute phase of Toxoplasma infectionInstituto Oswaldo Cruz, Ministério da Saúde1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100018Memórias do Instituto Oswaldo Cruz v.93 n.1 1998reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761998000100018info:eu-repo/semantics/openAccessFavoreto-Junior,SílvioAV Ferro,EloísaClemente,DiogoSilva,Deise AOMineo,José Reng2020-04-25T17:47:49Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:07:56.569Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
title Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
spellingShingle Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
Favoreto-Junior,Sílvio
Toxopasma gondii
Calomys callosus
experimental infection
title_short Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
title_full Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
title_fullStr Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
title_full_unstemmed Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
title_sort Experimental Infection of Calomys callosus (Rodentia, Cricetidae) by Toxoplasma gondii
author Favoreto-Junior,Sílvio
author_facet Favoreto-Junior,Sílvio
AV Ferro,Eloísa
Clemente,Diogo
Silva,Deise AO
Mineo,José R
author_role author
author2 AV Ferro,Eloísa
Clemente,Diogo
Silva,Deise AO
Mineo,José R
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Favoreto-Junior,Sílvio
AV Ferro,Eloísa
Clemente,Diogo
Silva,Deise AO
Mineo,José R
dc.subject.por.fl_str_mv Toxopasma gondii
Calomys callosus
experimental infection
topic Toxopasma gondii
Calomys callosus
experimental infection
dc.description.none.fl_txt_mv Calomys callosus, Rengger 1830 (Rodentia, Cricetidae), a wild rodent found in Central Brazil, was studied to investigate its susceptibility to Toxoplasma gondii experimental infection and its humoral immune response against this protozoa. The electrophoretic profile of the serum proteins of C. callosus showed that IgG, which shows no affinity to Protein A, has higher cross reactivity with rat IgG than with IgG from other rodents. The susceptibility assay was performed by inoculation groups of animals with various suspensions of T. gondii tachyzoites from 102 to 106 parasites. All animals died between 3 and 9 days after infection and the kinetics of antibody synthesis was determined. Basically, they recognized predominantly the immunodominant antigen SAG-1 (P30). The immunohistochemistry assays revealed that the liver was the most heavily infected organ, followed by the spleen, lungs, intestine, brain and kidneys. It can be concluded that C. callosus is an excellent experimental model for acute phase of Toxoplasma infection
description Calomys callosus, Rengger 1830 (Rodentia, Cricetidae), a wild rodent found in Central Brazil, was studied to investigate its susceptibility to Toxoplasma gondii experimental infection and its humoral immune response against this protozoa. The electrophoretic profile of the serum proteins of C. callosus showed that IgG, which shows no affinity to Protein A, has higher cross reactivity with rat IgG than with IgG from other rodents. The susceptibility assay was performed by inoculation groups of animals with various suspensions of T. gondii tachyzoites from 102 to 106 parasites. All animals died between 3 and 9 days after infection and the kinetics of antibody synthesis was determined. Basically, they recognized predominantly the immunodominant antigen SAG-1 (P30). The immunohistochemistry assays revealed that the liver was the most heavily infected organ, followed by the spleen, lungs, intestine, brain and kidneys. It can be concluded that C. callosus is an excellent experimental model for acute phase of Toxoplasma infection
publishDate 1998
dc.date.none.fl_str_mv 1998-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100018
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000100018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761998000100018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.93 n.1 1998
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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