RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics

Detalhes bibliográficos
Autor(a) principal: Razanamparany,Voahangy Rasolofo
Data de Publicação: 2009
Outros Autores: Ramarokoto,Herimanana H, Vololonirina,Elie J, Rasolonavalona,Tiana, Michault,Alain, Pyndiah,Naidu, Seenundun,Rajbunsing, Sandven,Per, Chanteau,Suzanne
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300007
Resumo: This is the first study describing the genetic polymorphism of Mycobacterium tuberculosis strains in the Indian Ocean Region. Using IS6110 RFLP analysis, 475 M. tuberculosis isolates from Madagascar, Comoros, Mauritius, Mozambique and La Reunion were compared. Of the 332 IS6110 profiles found, 43 were shared by clusters containing 2-65 strains. Six clusters were common to at least two countries. Of 52 families of strains with similar IS6110 profiles, 10 were common to at least two countries. Interestingly, another characteristic was the frequency (16.8%) of IS6110 single-copy strains. These strains could be distinguished using the DR marker. This preliminary evaluation suggests genetic similarity between the strains of the Indian Ocean Region. However, additional markers would be useful for epidemiological studies and to assess the ancient transmission of strains between countries of this region.
id FIOCRUZ-4_cf08005c77cae19fd5e24be16bc79194
oai_identifier_str oai:scielo:S0074-02762009000300007
network_acronym_str FIOCRUZ-4
network_name_str Memórias do Instituto Oswaldo Cruz
spelling RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristicsMycobacterium tuberculosisIS6110 RFLPIndian Ocean RegionThis is the first study describing the genetic polymorphism of Mycobacterium tuberculosis strains in the Indian Ocean Region. Using IS6110 RFLP analysis, 475 M. tuberculosis isolates from Madagascar, Comoros, Mauritius, Mozambique and La Reunion were compared. Of the 332 IS6110 profiles found, 43 were shared by clusters containing 2-65 strains. Six clusters were common to at least two countries. Of 52 families of strains with similar IS6110 profiles, 10 were common to at least two countries. Interestingly, another characteristic was the frequency (16.8%) of IS6110 single-copy strains. These strains could be distinguished using the DR marker. This preliminary evaluation suggests genetic similarity between the strains of the Indian Ocean Region. However, additional markers would be useful for epidemiological studies and to assess the ancient transmission of strains between countries of this region.Instituto Oswaldo Cruz, Ministério da Saúde2009-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300007Memórias do Instituto Oswaldo Cruz v.104 n.3 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000300007info:eu-repo/semantics/openAccessRazanamparany,Voahangy RasolofoRamarokoto,Herimanana HVololonirina,Elie JRasolonavalona,TianaMichault,AlainPyndiah,NaiduSeenundun,RajbunsingSandven,PerChanteau,Suzanneeng2020-04-25T17:50:28Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:10.636Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
title RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
spellingShingle RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
Razanamparany,Voahangy Rasolofo
Mycobacterium tuberculosis
IS6110 RFLP
Indian Ocean Region
title_short RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
title_full RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
title_fullStr RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
title_full_unstemmed RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
title_sort RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics
author Razanamparany,Voahangy Rasolofo
author_facet Razanamparany,Voahangy Rasolofo
Ramarokoto,Herimanana H
Vololonirina,Elie J
Rasolonavalona,Tiana
Michault,Alain
Pyndiah,Naidu
Seenundun,Rajbunsing
Sandven,Per
Chanteau,Suzanne
author_role author
author2 Ramarokoto,Herimanana H
Vololonirina,Elie J
Rasolonavalona,Tiana
Michault,Alain
Pyndiah,Naidu
Seenundun,Rajbunsing
Sandven,Per
Chanteau,Suzanne
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Razanamparany,Voahangy Rasolofo
Ramarokoto,Herimanana H
Vololonirina,Elie J
Rasolonavalona,Tiana
Michault,Alain
Pyndiah,Naidu
Seenundun,Rajbunsing
Sandven,Per
Chanteau,Suzanne
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
IS6110 RFLP
Indian Ocean Region
topic Mycobacterium tuberculosis
IS6110 RFLP
Indian Ocean Region
dc.description.none.fl_txt_mv This is the first study describing the genetic polymorphism of Mycobacterium tuberculosis strains in the Indian Ocean Region. Using IS6110 RFLP analysis, 475 M. tuberculosis isolates from Madagascar, Comoros, Mauritius, Mozambique and La Reunion were compared. Of the 332 IS6110 profiles found, 43 were shared by clusters containing 2-65 strains. Six clusters were common to at least two countries. Of 52 families of strains with similar IS6110 profiles, 10 were common to at least two countries. Interestingly, another characteristic was the frequency (16.8%) of IS6110 single-copy strains. These strains could be distinguished using the DR marker. This preliminary evaluation suggests genetic similarity between the strains of the Indian Ocean Region. However, additional markers would be useful for epidemiological studies and to assess the ancient transmission of strains between countries of this region.
description This is the first study describing the genetic polymorphism of Mycobacterium tuberculosis strains in the Indian Ocean Region. Using IS6110 RFLP analysis, 475 M. tuberculosis isolates from Madagascar, Comoros, Mauritius, Mozambique and La Reunion were compared. Of the 332 IS6110 profiles found, 43 were shared by clusters containing 2-65 strains. Six clusters were common to at least two countries. Of 52 families of strains with similar IS6110 profiles, 10 were common to at least two countries. Interestingly, another characteristic was the frequency (16.8%) of IS6110 single-copy strains. These strains could be distinguished using the DR marker. This preliminary evaluation suggests genetic similarity between the strains of the Indian Ocean Region. However, additional markers would be useful for epidemiological studies and to assess the ancient transmission of strains between countries of this region.
publishDate 2009
dc.date.none.fl_str_mv 2009-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300007
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762009000300007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.104 n.3 2009
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937704378302464

Registros relacionados