The association of genetic markers and malaria infection in the Brazilian Western Amazonian region

Detalhes bibliográficos
Autor(a) principal: Beiguelman,B
Data de Publicação: 2003
Outros Autores: Alves,FP, Moura,MM, Engracia,V, Nunes,ACS, Heckmann,MIO, Ferreira,RGM, Pereira da Silva,LH, Camargo,EP, Krieger,H
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400004
Resumo: Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings.
id FIOCRUZ-4_e4d9e94f06647aa4b0bf613751b8f95c
oai_identifier_str oai:scielo:S0074-02762003000400004
network_acronym_str FIOCRUZ-4
network_name_str Memórias do Instituto Oswaldo Cruz
spelling The association of genetic markers and malaria infection in the Brazilian Western Amazonian regionmalariagenetic markersassociation studiesWestern AmazoniaRondôniaBrazilAlmost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings.Instituto Oswaldo Cruz, Ministério da Saúde2003-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400004Memórias do Instituto Oswaldo Cruz v.98 n.4 2003reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762003000400004info:eu-repo/semantics/openAccessBeiguelman,BAlves,FPMoura,MMEngracia,VNunes,ACSHeckmann,MIOFerreira,RGMPereira da Silva,LHCamargo,EPKrieger,Heng2020-04-25T17:49:03Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:11:57.241Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
title The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
spellingShingle The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
Beiguelman,B
malaria
genetic markers
association studies
Western Amazonia
Rondônia
Brazil
title_short The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
title_full The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
title_fullStr The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
title_full_unstemmed The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
title_sort The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
author Beiguelman,B
author_facet Beiguelman,B
Alves,FP
Moura,MM
Engracia,V
Nunes,ACS
Heckmann,MIO
Ferreira,RGM
Pereira da Silva,LH
Camargo,EP
Krieger,H
author_role author
author2 Alves,FP
Moura,MM
Engracia,V
Nunes,ACS
Heckmann,MIO
Ferreira,RGM
Pereira da Silva,LH
Camargo,EP
Krieger,H
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Beiguelman,B
Alves,FP
Moura,MM
Engracia,V
Nunes,ACS
Heckmann,MIO
Ferreira,RGM
Pereira da Silva,LH
Camargo,EP
Krieger,H
dc.subject.por.fl_str_mv malaria
genetic markers
association studies
Western Amazonia
Rondônia
Brazil
topic malaria
genetic markers
association studies
Western Amazonia
Rondônia
Brazil
dc.description.none.fl_txt_mv Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings.
description Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400004
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762003000400004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.98 n.4 2003
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937689285099520

Registros relacionados