Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children

Detalhes bibliográficos
Autor(a) principal: Sowunmi,Akintunde
Data de Publicação: 2008
Outros Autores: Balogun,Sulayman T, Gbotosho,Grace O, Happi,Christian T
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800002
Resumo: Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction. Over half of recrudescent events occurred after 14 days of initiation of treatment and were associated with relatively low asexual parasitaemia. We examined the gametocyte sex ratio (GSR) in these children and in age and gender-matched controls that had AQ-sensitive (AQ-S) infections (n = 50). In both AQ-S and AQ-resistant (AQ-R) infections, the GSR was female-biased pre-treatment and became male-biased by the third day after treatment initiation. However, gametocyte males persisted after this period in children with AQ-R infections. AQ-recrudescent infections are relatively low (25 of 612.4%) in children from this endemic area.
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spelling Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian childrenamodiaquinerecrudescencemalariagametocyte sex ratiochildrenNigeriaCharacteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction. Over half of recrudescent events occurred after 14 days of initiation of treatment and were associated with relatively low asexual parasitaemia. We examined the gametocyte sex ratio (GSR) in these children and in age and gender-matched controls that had AQ-sensitive (AQ-S) infections (n = 50). In both AQ-S and AQ-resistant (AQ-R) infections, the GSR was female-biased pre-treatment and became male-biased by the third day after treatment initiation. However, gametocyte males persisted after this period in children with AQ-R infections. AQ-recrudescent infections are relatively low (25 of 612.4%) in children from this endemic area.Instituto Oswaldo Cruz, Ministério da Saúde2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800002Memórias do Instituto Oswaldo Cruz v.103 n.8 2008reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762008000800002info:eu-repo/semantics/openAccessSowunmi,AkintundeBalogun,Sulayman TGbotosho,Grace OHappi,Christian Teng2020-04-25T17:50:22Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:15:51.33Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
title Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
spellingShingle Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
Sowunmi,Akintunde
amodiaquine
recrudescence
malaria
gametocyte sex ratio
children
Nigeria
title_short Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
title_full Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
title_fullStr Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
title_full_unstemmed Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
title_sort Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children
author Sowunmi,Akintunde
author_facet Sowunmi,Akintunde
Balogun,Sulayman T
Gbotosho,Grace O
Happi,Christian T
author_role author
author2 Balogun,Sulayman T
Gbotosho,Grace O
Happi,Christian T
author2_role author
author
author
dc.contributor.author.fl_str_mv Sowunmi,Akintunde
Balogun,Sulayman T
Gbotosho,Grace O
Happi,Christian T
dc.subject.por.fl_str_mv amodiaquine
recrudescence
malaria
gametocyte sex ratio
children
Nigeria
topic amodiaquine
recrudescence
malaria
gametocyte sex ratio
children
Nigeria
dc.description.none.fl_txt_mv Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction. Over half of recrudescent events occurred after 14 days of initiation of treatment and were associated with relatively low asexual parasitaemia. We examined the gametocyte sex ratio (GSR) in these children and in age and gender-matched controls that had AQ-sensitive (AQ-S) infections (n = 50). In both AQ-S and AQ-resistant (AQ-R) infections, the GSR was female-biased pre-treatment and became male-biased by the third day after treatment initiation. However, gametocyte males persisted after this period in children with AQ-R infections. AQ-recrudescent infections are relatively low (25 of 612.4%) in children from this endemic area.
description Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction. Over half of recrudescent events occurred after 14 days of initiation of treatment and were associated with relatively low asexual parasitaemia. We examined the gametocyte sex ratio (GSR) in these children and in age and gender-matched controls that had AQ-sensitive (AQ-S) infections (n = 50). In both AQ-S and AQ-resistant (AQ-R) infections, the GSR was female-biased pre-treatment and became male-biased by the third day after treatment initiation. However, gametocyte males persisted after this period in children with AQ-R infections. AQ-recrudescent infections are relatively low (25 of 612.4%) in children from this endemic area.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800002
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762008000800002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.103 n.8 2008
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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