NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection

Detalhes bibliográficos
Autor(a) principal: Kamada,Anselmo Jiro
Data de Publicação: 2014
Outros Autores: Pontillo,Alessandra, Guimarães,Rafael Lima, Loureiro,Paula, Crovella,Sergio, Brandão,Lucas André Cavalcanti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700957
Resumo: Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.
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spelling NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infectionNLRP3NLRP1single nucleotide polymorphismsinnate immunityHTLV-1Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.Instituto Oswaldo Cruz, Ministério da Saúde2014-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700957Memórias do Instituto Oswaldo Cruz v.109 n.7 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276140154info:eu-repo/semantics/openAccessKamada,Anselmo JiroPontillo,AlessandraGuimarães,Rafael LimaLoureiro,PaulaCrovella,SergioBrandão,Lucas André Cavalcantieng2020-04-25T17:51:49Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:54.618Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
title NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
spellingShingle NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
Kamada,Anselmo Jiro
NLRP3
NLRP1
single nucleotide polymorphisms
innate immunity
HTLV-1
title_short NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
title_full NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
title_fullStr NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
title_full_unstemmed NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
title_sort NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
author Kamada,Anselmo Jiro
author_facet Kamada,Anselmo Jiro
Pontillo,Alessandra
Guimarães,Rafael Lima
Loureiro,Paula
Crovella,Sergio
Brandão,Lucas André Cavalcanti
author_role author
author2 Pontillo,Alessandra
Guimarães,Rafael Lima
Loureiro,Paula
Crovella,Sergio
Brandão,Lucas André Cavalcanti
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Kamada,Anselmo Jiro
Pontillo,Alessandra
Guimarães,Rafael Lima
Loureiro,Paula
Crovella,Sergio
Brandão,Lucas André Cavalcanti
dc.subject.por.fl_str_mv NLRP3
NLRP1
single nucleotide polymorphisms
innate immunity
HTLV-1
topic NLRP3
NLRP1
single nucleotide polymorphisms
innate immunity
HTLV-1
dc.description.none.fl_txt_mv Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.
description Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700957
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700957
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276140154
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.7 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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