Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)

Detalhes bibliográficos
Autor(a) principal: Thornhill,Joyce
Data de Publicação: 2010
Outros Autores: Kusel,John, Oliviera,Fabricia Alvisi de, Ribeiro,Fabio, Lima,Symone Fulgêncio, Coelho,Paulo Marcos Zech, McVeigh,Paul, Mattos,Ana Carolina Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400007
Resumo: Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.
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spelling Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)Schistosoma mansonimembrane impermeant Lucifer Yellownephridioporehost/parasite interfacelinoleic acidHere, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.Instituto Oswaldo Cruz, Ministério da Saúde2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400007Memórias do Instituto Oswaldo Cruz v.105 n.4 2010reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762010000400007info:eu-repo/semantics/openAccessThornhill,JoyceKusel,JohnOliviera,Fabricia Alvisi deRibeiro,FabioLima,Symone FulgêncioCoelho,Paulo Marcos ZechMcVeigh,PaulMattos,Ana Carolina Alveseng2020-04-25T17:50:47Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:58.008Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
spellingShingle Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
Thornhill,Joyce
Schistosoma mansoni
membrane impermeant Lucifer Yellow
nephridiopore
host/parasite interface
linoleic acid
title_short Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_full Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_fullStr Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_full_unstemmed Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
title_sort Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
author Thornhill,Joyce
author_facet Thornhill,Joyce
Kusel,John
Oliviera,Fabricia Alvisi de
Ribeiro,Fabio
Lima,Symone Fulgêncio
Coelho,Paulo Marcos Zech
McVeigh,Paul
Mattos,Ana Carolina Alves
author_role author
author2 Kusel,John
Oliviera,Fabricia Alvisi de
Ribeiro,Fabio
Lima,Symone Fulgêncio
Coelho,Paulo Marcos Zech
McVeigh,Paul
Mattos,Ana Carolina Alves
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Thornhill,Joyce
Kusel,John
Oliviera,Fabricia Alvisi de
Ribeiro,Fabio
Lima,Symone Fulgêncio
Coelho,Paulo Marcos Zech
McVeigh,Paul
Mattos,Ana Carolina Alves
dc.subject.por.fl_str_mv Schistosoma mansoni
membrane impermeant Lucifer Yellow
nephridiopore
host/parasite interface
linoleic acid
topic Schistosoma mansoni
membrane impermeant Lucifer Yellow
nephridiopore
host/parasite interface
linoleic acid
dc.description.none.fl_txt_mv Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.
description Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400007
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762010000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.105 n.4 2010
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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