Vertical transmission of the human papillomavirus: a systematic quantitative review
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512 |
Resumo: | In order to better understand the exact mode and risk of vertical transmission in asymptomatic pregnant women, as well as the relationship between HPV transmission and mode of delivery, we have proposed this systematic quantitative review of prospective cohort studies. A comprehensive search was performed in the Cochrane Library, MEDLINE, LILACS, CANCERLIT, and EMBASE, as well as in the reference lists from the identified studies. Nine primary studies, which included 2,111 pregnant women and 2,113 newborns, met our selection criteria and were analyzed. A positive HPV test in the mother increased the risk of vertical HPV transmission (RR: 4.8; 95%CI: 2.2-10.4). We also observed a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The results of this meta-analysis showed the HPV DNA-positive rate only after birth, but an HPV DNA-positive neonatal sample does not necessarily indicate infection; it could merely indicate contamination (perinatal HPV contamination may have occurred). Infants born through vaginal delivery were at higher risk of exposure to HPV. |
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Vertical transmission of the human papillomavirus: a systematic quantitative reviewSystematic ReviewMeta-AnalysisVertical TransmissionPapillomavirusIn order to better understand the exact mode and risk of vertical transmission in asymptomatic pregnant women, as well as the relationship between HPV transmission and mode of delivery, we have proposed this systematic quantitative review of prospective cohort studies. A comprehensive search was performed in the Cochrane Library, MEDLINE, LILACS, CANCERLIT, and EMBASE, as well as in the reference lists from the identified studies. Nine primary studies, which included 2,111 pregnant women and 2,113 newborns, met our selection criteria and were analyzed. A positive HPV test in the mother increased the risk of vertical HPV transmission (RR: 4.8; 95%CI: 2.2-10.4). We also observed a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The results of this meta-analysis showed the HPV DNA-positive rate only after birth, but an HPV DNA-positive neonatal sample does not necessarily indicate infection; it could merely indicate contamination (perinatal HPV contamination may have occurred). Infants born through vaginal delivery were at higher risk of exposure to HPV.Para entendimento do modo exato de transmissão vertical e de seu risco em gestantes assintomáticas, bem como a relação entre a transmissão de HPV e o tipo de parto, foi proposta uma revisão sistemática quantitativa de coortes prospectivas. Foi realizada uma busca na Biblioteca Cochrane, MEDLINE, LILACS, CANCERLIT e EMBASE e nas referências dos estudos identificados. Nove estudos, que contaram com 2.111 gestantes e 2.113 recém-nascidos, foram incluídos de acordo com critério de seleção e foram analisados. O teste positivo para HPV na mãe aumentou o risco de transmissão vertical para HPV, com risco relativo (RR = 4,8; IC95%: 2,2-10,4). Foi observado um maior risco de infecção por HPV após parto vaginal (RR = 1,8; IC95%: 1,3-2,4). Os resultados dessa metanálise mostraram uma taxa de positividade para o DNA do HPV somente após o nascimento, porém a taxa de positividade para DNA do HPV em amostras de recém-nascidos não indica infecção; pode indicar apenas contaminação. Concluiu-se que a transmissão perinatal de HPV pode ocorrer e, após parto vaginal, os recém nascidos têm risco maior para exposição ao vírus.Reports in Public HealthCadernos de Saúde Pública2005-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512Reports in Public Health; Vol. 21 No. 4 (2005): July/AugustCadernos de Saúde Pública; v. 21 n. 4 (2005): Julho/Agosto1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5036https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5037Medeiros, Lidia RosiEthur, Anaelena Bragança de MoraesHilgert, Juliana BalbinotZanini, Roselaine RuviaroBerwanger, OtávioBozzetti, Mary ClarisseMylius, Luciane Calilinfo:eu-repo/semantics/openAccess2024-03-06T15:27:05Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/2512Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:02:56.532553Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
dc.title.none.fl_str_mv |
Vertical transmission of the human papillomavirus: a systematic quantitative review |
title |
Vertical transmission of the human papillomavirus: a systematic quantitative review |
spellingShingle |
Vertical transmission of the human papillomavirus: a systematic quantitative review Medeiros, Lidia Rosi Systematic Review Meta-Analysis Vertical Transmission Papillomavirus |
title_short |
Vertical transmission of the human papillomavirus: a systematic quantitative review |
title_full |
Vertical transmission of the human papillomavirus: a systematic quantitative review |
title_fullStr |
Vertical transmission of the human papillomavirus: a systematic quantitative review |
title_full_unstemmed |
Vertical transmission of the human papillomavirus: a systematic quantitative review |
title_sort |
Vertical transmission of the human papillomavirus: a systematic quantitative review |
author |
Medeiros, Lidia Rosi |
author_facet |
Medeiros, Lidia Rosi Ethur, Anaelena Bragança de Moraes Hilgert, Juliana Balbinot Zanini, Roselaine Ruviaro Berwanger, Otávio Bozzetti, Mary Clarisse Mylius, Luciane Calil |
author_role |
author |
author2 |
Ethur, Anaelena Bragança de Moraes Hilgert, Juliana Balbinot Zanini, Roselaine Ruviaro Berwanger, Otávio Bozzetti, Mary Clarisse Mylius, Luciane Calil |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Medeiros, Lidia Rosi Ethur, Anaelena Bragança de Moraes Hilgert, Juliana Balbinot Zanini, Roselaine Ruviaro Berwanger, Otávio Bozzetti, Mary Clarisse Mylius, Luciane Calil |
dc.subject.por.fl_str_mv |
Systematic Review Meta-Analysis Vertical Transmission Papillomavirus |
topic |
Systematic Review Meta-Analysis Vertical Transmission Papillomavirus |
description |
In order to better understand the exact mode and risk of vertical transmission in asymptomatic pregnant women, as well as the relationship between HPV transmission and mode of delivery, we have proposed this systematic quantitative review of prospective cohort studies. A comprehensive search was performed in the Cochrane Library, MEDLINE, LILACS, CANCERLIT, and EMBASE, as well as in the reference lists from the identified studies. Nine primary studies, which included 2,111 pregnant women and 2,113 newborns, met our selection criteria and were analyzed. A positive HPV test in the mother increased the risk of vertical HPV transmission (RR: 4.8; 95%CI: 2.2-10.4). We also observed a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The results of this meta-analysis showed the HPV DNA-positive rate only after birth, but an HPV DNA-positive neonatal sample does not necessarily indicate infection; it could merely indicate contamination (perinatal HPV contamination may have occurred). Infants born through vaginal delivery were at higher risk of exposure to HPV. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512 |
url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5036 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5037 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 21 No. 4 (2005): July/August Cadernos de Saúde Pública; v. 21 n. 4 (2005): Julho/Agosto 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
_version_ |
1816705353343041536 |