Vertical transmission of the human papillomavirus: a systematic quantitative review

Detalhes bibliográficos
Autor(a) principal: Medeiros, Lidia Rosi
Data de Publicação: 2005
Outros Autores: Ethur, Anaelena Bragança de Moraes, Hilgert, Juliana Balbinot, Zanini, Roselaine Ruviaro, Berwanger, Otávio, Bozzetti, Mary Clarisse, Mylius, Luciane Calil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512
Resumo: In order to better understand the exact mode and risk of vertical transmission in asymptomatic pregnant women, as well as the relationship between HPV transmission and mode of delivery, we have proposed this systematic quantitative review of prospective cohort studies. A comprehensive search was performed in the Cochrane Library, MEDLINE, LILACS, CANCERLIT, and EMBASE, as well as in the reference lists from the identified studies. Nine primary studies, which included 2,111 pregnant women and 2,113 newborns, met our selection criteria and were analyzed. A positive HPV test in the mother increased the risk of vertical HPV transmission (RR: 4.8; 95%CI: 2.2-10.4). We also observed a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The results of this meta-analysis showed the HPV DNA-positive rate only after birth, but an HPV DNA-positive neonatal sample does not necessarily indicate infection; it could merely indicate contamination (perinatal HPV contamination may have occurred). Infants born through vaginal delivery were at higher risk of exposure to HPV.
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spelling Vertical transmission of the human papillomavirus: a systematic quantitative reviewSystematic ReviewMeta-AnalysisVertical TransmissionPapillomavirusIn order to better understand the exact mode and risk of vertical transmission in asymptomatic pregnant women, as well as the relationship between HPV transmission and mode of delivery, we have proposed this systematic quantitative review of prospective cohort studies. A comprehensive search was performed in the Cochrane Library, MEDLINE, LILACS, CANCERLIT, and EMBASE, as well as in the reference lists from the identified studies. Nine primary studies, which included 2,111 pregnant women and 2,113 newborns, met our selection criteria and were analyzed. A positive HPV test in the mother increased the risk of vertical HPV transmission (RR: 4.8; 95%CI: 2.2-10.4). We also observed a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The results of this meta-analysis showed the HPV DNA-positive rate only after birth, but an HPV DNA-positive neonatal sample does not necessarily indicate infection; it could merely indicate contamination (perinatal HPV contamination may have occurred). Infants born through vaginal delivery were at higher risk of exposure to HPV.Para entendimento do modo exato de transmissão vertical e de seu risco em gestantes assintomáticas, bem como a relação entre a transmissão de HPV e o tipo de parto, foi proposta uma revisão sistemática quantitativa de coortes prospectivas. Foi realizada uma busca na Biblioteca Cochrane, MEDLINE, LILACS, CANCERLIT e EMBASE e nas referências dos estudos identificados. Nove estudos, que contaram com 2.111 gestantes e 2.113 recém-nascidos, foram incluídos de acordo com critério de seleção e foram analisados. O teste positivo para HPV na mãe aumentou o risco de transmissão vertical para HPV, com risco relativo (RR = 4,8; IC95%: 2,2-10,4). Foi observado um maior risco de infecção por HPV após parto vaginal (RR = 1,8; IC95%: 1,3-2,4). Os resultados dessa metanálise mostraram uma taxa de positividade para o DNA do HPV somente após o nascimento, porém a taxa de positividade para DNA do HPV em amostras de recém-nascidos não indica infecção; pode indicar apenas contaminação. Concluiu-se que a transmissão perinatal de HPV pode ocorrer e, após parto vaginal, os recém nascidos têm risco maior para exposição ao vírus.Reports in Public HealthCadernos de Saúde Pública2005-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512Reports in Public Health; Vol. 21 No. 4 (2005): July/AugustCadernos de Saúde Pública; v. 21 n. 4 (2005): Julho/Agosto1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5036https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5037Medeiros, Lidia RosiEthur, Anaelena Bragança de MoraesHilgert, Juliana BalbinotZanini, Roselaine RuviaroBerwanger, OtávioBozzetti, Mary ClarisseMylius, Luciane Calilinfo:eu-repo/semantics/openAccess2024-03-06T15:27:05Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/2512Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:02:56.532553Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Vertical transmission of the human papillomavirus: a systematic quantitative review
title Vertical transmission of the human papillomavirus: a systematic quantitative review
spellingShingle Vertical transmission of the human papillomavirus: a systematic quantitative review
Medeiros, Lidia Rosi
Systematic Review
Meta-Analysis
Vertical Transmission
Papillomavirus
title_short Vertical transmission of the human papillomavirus: a systematic quantitative review
title_full Vertical transmission of the human papillomavirus: a systematic quantitative review
title_fullStr Vertical transmission of the human papillomavirus: a systematic quantitative review
title_full_unstemmed Vertical transmission of the human papillomavirus: a systematic quantitative review
title_sort Vertical transmission of the human papillomavirus: a systematic quantitative review
author Medeiros, Lidia Rosi
author_facet Medeiros, Lidia Rosi
Ethur, Anaelena Bragança de Moraes
Hilgert, Juliana Balbinot
Zanini, Roselaine Ruviaro
Berwanger, Otávio
Bozzetti, Mary Clarisse
Mylius, Luciane Calil
author_role author
author2 Ethur, Anaelena Bragança de Moraes
Hilgert, Juliana Balbinot
Zanini, Roselaine Ruviaro
Berwanger, Otávio
Bozzetti, Mary Clarisse
Mylius, Luciane Calil
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Medeiros, Lidia Rosi
Ethur, Anaelena Bragança de Moraes
Hilgert, Juliana Balbinot
Zanini, Roselaine Ruviaro
Berwanger, Otávio
Bozzetti, Mary Clarisse
Mylius, Luciane Calil
dc.subject.por.fl_str_mv Systematic Review
Meta-Analysis
Vertical Transmission
Papillomavirus
topic Systematic Review
Meta-Analysis
Vertical Transmission
Papillomavirus
description In order to better understand the exact mode and risk of vertical transmission in asymptomatic pregnant women, as well as the relationship between HPV transmission and mode of delivery, we have proposed this systematic quantitative review of prospective cohort studies. A comprehensive search was performed in the Cochrane Library, MEDLINE, LILACS, CANCERLIT, and EMBASE, as well as in the reference lists from the identified studies. Nine primary studies, which included 2,111 pregnant women and 2,113 newborns, met our selection criteria and were analyzed. A positive HPV test in the mother increased the risk of vertical HPV transmission (RR: 4.8; 95%CI: 2.2-10.4). We also observed a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The results of this meta-analysis showed the HPV DNA-positive rate only after birth, but an HPV DNA-positive neonatal sample does not necessarily indicate infection; it could merely indicate contamination (perinatal HPV contamination may have occurred). Infants born through vaginal delivery were at higher risk of exposure to HPV.
publishDate 2005
dc.date.none.fl_str_mv 2005-08-01
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dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5036
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2512/5037
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
application/pdf
dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 21 No. 4 (2005): July/August
Cadernos de Saúde Pública; v. 21 n. 4 (2005): Julho/Agosto
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
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