Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study

Detalhes bibliográficos
Autor(a) principal: Rodrigo Zunzarren Megale
Data de Publicação: 2016
Outros Autores: Antônio Ignácio de Loyola Filho, Josélia Oliveira Araújo Firmo, Maria Fernanda Lima-Costa, Sérgio Viana Peixoto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115
Resumo: Abstract Numerous studies have associated the apolipoprotein E (apoE) ε4 allele with worse health status, but few have assessed the existence of genotype-dependent variations in functional performance. Among participants in the Bambuí Health and Aging Study, Minas Gerais State, Brazil, 1,408 elderly underwent apoE genotyping. Functionality was assessed with a questionnaire, and individuals were classified as dependent in basic activities of daily living (BADLs), instrumental activities of daily living (IADLs), and mobility. The association between apoE genotype and functional status was assessed by logistic regression, taking confounding factors into account. Presence of ε4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis. There were no significant differences in relation to presence of dependency in BADLs and IADLs. The reasons are not entirely understood, but they may involve the role of ε4 allele as a “thrifty gene” in a sample exposed to high risk of infectious and nutritional diseases in the past.
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spelling Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging StudyApolipoprotein E4Disabled PersonsAgedAbstract Numerous studies have associated the apolipoprotein E (apoE) ε4 allele with worse health status, but few have assessed the existence of genotype-dependent variations in functional performance. Among participants in the Bambuí Health and Aging Study, Minas Gerais State, Brazil, 1,408 elderly underwent apoE genotyping. Functionality was assessed with a questionnaire, and individuals were classified as dependent in basic activities of daily living (BADLs), instrumental activities of daily living (IADLs), and mobility. The association between apoE genotype and functional status was assessed by logistic regression, taking confounding factors into account. Presence of ε4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis. There were no significant differences in relation to presence of dependency in BADLs and IADLs. The reasons are not entirely understood, but they may involve the role of ε4 allele as a “thrifty gene” in a sample exposed to high risk of infectious and nutritional diseases in the past.Resumen Innumerables estudios han asociado el alelo ε4 de la apolipoproteína E (apoE) con una peor condición de salud, pero pocos evaluaron la existencia de variaciones genotipo-dependientes en el desempeño funcional. Entre los participantes de la cohorte de Bambuí, Minas Gerais, Brasil, 1.408 ancianos fueron sometidos a una determinación del genotipo de la apoE. La funcionalidad fue evaluada por cuestionario, siendo los individuos clasificados en: dependientes para actividades básicas de la vida diaria (ABVDs), actividades instrumentales de la vida diaria (AIVDs) y movilidad. La asociación entre el genotipo de la apoE y el estado funcional fue evaluada por regresión logística, considerando variables de confusión. La presencia del alelo ε4 fue asociada a una menor probabilidad de déficit en la movilidad (OR = 0,65; IC95%: 0,47-0,92) en el análisis ajustado. No hubo diferencias significativas en relación con la presencia de incapacidades en ABVDs y AIVDs. Los motivos no están completamente claros, pero pueden están involucrados por su papel como un “thrifty gene” en una muestra expuesta a un riesgo elevado de enfermedades infecciosas y nutricionales en el pasado.Resumo Inúmeros estudos têm associado o alelo ε4 da apolipoproteína E (apoE) com pior condição de saúde, mas poucos avaliaram a existência de variações genótipo-dependentes no desempenho funcional. Entre os participantes da coorte de Bambuí, Minas Gerais, Brasil, 1.408 idosos foram submetidos à genotipagem da apoE. A funcionalidade foi avaliada por questionário, sendo os indivíduos classificados em dependentes para atividades básicas da vida diária (ABVDs), atividades instrumentais da vida diária (AIVDs) e mobilidade. A associação entre o genótipo da apoE e o estado funcional foi avaliada pela regressão logística, considerando variáveis de confusão. A presença do alelo ε4 foi associada a uma menor chance de déficit na mobilidade (OR = 0,65; IC95%: 0,47-0,92), na análise ajustada. Não houve diferenças significativas em relação à presença de incapacidades em ABVDs e AIVDs. Os motivos não estão completamente compreendidos, mas podem envolver o seu papel como um “thrifty gene” em uma amostra exposta a um risco elevado de doenças infecciosas e nutricionais no passado.Reports in Public HealthCadernos de Saúde Pública2016-03-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115Reports in Public Health; Vol. 32 No. 2 (2016): FebruaryCadernos de Saúde Pública; v. 32 n. 2 (2016): Fevereiro1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115/12904https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115/12905Rodrigo Zunzarren MegaleAntônio Ignácio de Loyola FilhoJosélia Oliveira Araújo FirmoMaria Fernanda Lima-CostaSérgio Viana Peixotoinfo:eu-repo/semantics/openAccess2024-03-06T15:29:08Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/6115Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:06:59.301729Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
title Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
spellingShingle Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
Rodrigo Zunzarren Megale
Apolipoprotein E4
Disabled Persons
Aged
title_short Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
title_full Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
title_fullStr Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
title_full_unstemmed Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
title_sort Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
author Rodrigo Zunzarren Megale
author_facet Rodrigo Zunzarren Megale
Antônio Ignácio de Loyola Filho
Josélia Oliveira Araújo Firmo
Maria Fernanda Lima-Costa
Sérgio Viana Peixoto
author_role author
author2 Antônio Ignácio de Loyola Filho
Josélia Oliveira Araújo Firmo
Maria Fernanda Lima-Costa
Sérgio Viana Peixoto
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rodrigo Zunzarren Megale
Antônio Ignácio de Loyola Filho
Josélia Oliveira Araújo Firmo
Maria Fernanda Lima-Costa
Sérgio Viana Peixoto
dc.subject.por.fl_str_mv Apolipoprotein E4
Disabled Persons
Aged
topic Apolipoprotein E4
Disabled Persons
Aged
description Abstract Numerous studies have associated the apolipoprotein E (apoE) ε4 allele with worse health status, but few have assessed the existence of genotype-dependent variations in functional performance. Among participants in the Bambuí Health and Aging Study, Minas Gerais State, Brazil, 1,408 elderly underwent apoE genotyping. Functionality was assessed with a questionnaire, and individuals were classified as dependent in basic activities of daily living (BADLs), instrumental activities of daily living (IADLs), and mobility. The association between apoE genotype and functional status was assessed by logistic regression, taking confounding factors into account. Presence of ε4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis. There were no significant differences in relation to presence of dependency in BADLs and IADLs. The reasons are not entirely understood, but they may involve the role of ε4 allele as a “thrifty gene” in a sample exposed to high risk of infectious and nutritional diseases in the past.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-04
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dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 32 No. 2 (2016): February
Cadernos de Saúde Pública; v. 32 n. 2 (2016): Fevereiro
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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