Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115 |
Resumo: | Abstract Numerous studies have associated the apolipoprotein E (apoE) ε4 allele with worse health status, but few have assessed the existence of genotype-dependent variations in functional performance. Among participants in the Bambuí Health and Aging Study, Minas Gerais State, Brazil, 1,408 elderly underwent apoE genotyping. Functionality was assessed with a questionnaire, and individuals were classified as dependent in basic activities of daily living (BADLs), instrumental activities of daily living (IADLs), and mobility. The association between apoE genotype and functional status was assessed by logistic regression, taking confounding factors into account. Presence of ε4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis. There were no significant differences in relation to presence of dependency in BADLs and IADLs. The reasons are not entirely understood, but they may involve the role of ε4 allele as a “thrifty gene” in a sample exposed to high risk of infectious and nutritional diseases in the past. |
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Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging StudyApolipoprotein E4Disabled PersonsAgedAbstract Numerous studies have associated the apolipoprotein E (apoE) ε4 allele with worse health status, but few have assessed the existence of genotype-dependent variations in functional performance. Among participants in the Bambuí Health and Aging Study, Minas Gerais State, Brazil, 1,408 elderly underwent apoE genotyping. Functionality was assessed with a questionnaire, and individuals were classified as dependent in basic activities of daily living (BADLs), instrumental activities of daily living (IADLs), and mobility. The association between apoE genotype and functional status was assessed by logistic regression, taking confounding factors into account. Presence of ε4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis. There were no significant differences in relation to presence of dependency in BADLs and IADLs. The reasons are not entirely understood, but they may involve the role of ε4 allele as a “thrifty gene” in a sample exposed to high risk of infectious and nutritional diseases in the past.Resumen Innumerables estudios han asociado el alelo ε4 de la apolipoproteína E (apoE) con una peor condición de salud, pero pocos evaluaron la existencia de variaciones genotipo-dependientes en el desempeño funcional. Entre los participantes de la cohorte de Bambuí, Minas Gerais, Brasil, 1.408 ancianos fueron sometidos a una determinación del genotipo de la apoE. La funcionalidad fue evaluada por cuestionario, siendo los individuos clasificados en: dependientes para actividades básicas de la vida diaria (ABVDs), actividades instrumentales de la vida diaria (AIVDs) y movilidad. La asociación entre el genotipo de la apoE y el estado funcional fue evaluada por regresión logística, considerando variables de confusión. La presencia del alelo ε4 fue asociada a una menor probabilidad de déficit en la movilidad (OR = 0,65; IC95%: 0,47-0,92) en el análisis ajustado. No hubo diferencias significativas en relación con la presencia de incapacidades en ABVDs y AIVDs. Los motivos no están completamente claros, pero pueden están involucrados por su papel como un “thrifty gene” en una muestra expuesta a un riesgo elevado de enfermedades infecciosas y nutricionales en el pasado.Resumo Inúmeros estudos têm associado o alelo ε4 da apolipoproteína E (apoE) com pior condição de saúde, mas poucos avaliaram a existência de variações genótipo-dependentes no desempenho funcional. Entre os participantes da coorte de Bambuí, Minas Gerais, Brasil, 1.408 idosos foram submetidos à genotipagem da apoE. A funcionalidade foi avaliada por questionário, sendo os indivíduos classificados em dependentes para atividades básicas da vida diária (ABVDs), atividades instrumentais da vida diária (AIVDs) e mobilidade. A associação entre o genótipo da apoE e o estado funcional foi avaliada pela regressão logística, considerando variáveis de confusão. A presença do alelo ε4 foi associada a uma menor chance de déficit na mobilidade (OR = 0,65; IC95%: 0,47-0,92), na análise ajustada. Não houve diferenças significativas em relação à presença de incapacidades em ABVDs e AIVDs. Os motivos não estão completamente compreendidos, mas podem envolver o seu papel como um “thrifty gene” em uma amostra exposta a um risco elevado de doenças infecciosas e nutricionais no passado.Reports in Public HealthCadernos de Saúde Pública2016-03-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115Reports in Public Health; Vol. 32 No. 2 (2016): FebruaryCadernos de Saúde Pública; v. 32 n. 2 (2016): Fevereiro1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115/12904https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115/12905Rodrigo Zunzarren MegaleAntônio Ignácio de Loyola FilhoJosélia Oliveira Araújo FirmoMaria Fernanda Lima-CostaSérgio Viana Peixotoinfo:eu-repo/semantics/openAccess2024-03-06T15:29:08Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/6115Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:06:59.301729Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
dc.title.none.fl_str_mv |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study |
title |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study |
spellingShingle |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study Rodrigo Zunzarren Megale Apolipoprotein E4 Disabled Persons Aged |
title_short |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study |
title_full |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study |
title_fullStr |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study |
title_full_unstemmed |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study |
title_sort |
Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study |
author |
Rodrigo Zunzarren Megale |
author_facet |
Rodrigo Zunzarren Megale Antônio Ignácio de Loyola Filho Josélia Oliveira Araújo Firmo Maria Fernanda Lima-Costa Sérgio Viana Peixoto |
author_role |
author |
author2 |
Antônio Ignácio de Loyola Filho Josélia Oliveira Araújo Firmo Maria Fernanda Lima-Costa Sérgio Viana Peixoto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rodrigo Zunzarren Megale Antônio Ignácio de Loyola Filho Josélia Oliveira Araújo Firmo Maria Fernanda Lima-Costa Sérgio Viana Peixoto |
dc.subject.por.fl_str_mv |
Apolipoprotein E4 Disabled Persons Aged |
topic |
Apolipoprotein E4 Disabled Persons Aged |
description |
Abstract Numerous studies have associated the apolipoprotein E (apoE) ε4 allele with worse health status, but few have assessed the existence of genotype-dependent variations in functional performance. Among participants in the Bambuí Health and Aging Study, Minas Gerais State, Brazil, 1,408 elderly underwent apoE genotyping. Functionality was assessed with a questionnaire, and individuals were classified as dependent in basic activities of daily living (BADLs), instrumental activities of daily living (IADLs), and mobility. The association between apoE genotype and functional status was assessed by logistic regression, taking confounding factors into account. Presence of ε4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis. There were no significant differences in relation to presence of dependency in BADLs and IADLs. The reasons are not entirely understood, but they may involve the role of ε4 allele as a “thrifty gene” in a sample exposed to high risk of infectious and nutritional diseases in the past. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115 |
url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115/12904 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6115/12905 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 32 No. 2 (2016): February Cadernos de Saúde Pública; v. 32 n. 2 (2016): Fevereiro 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
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1798943381713321984 |