Adherence to antiretroviral therapy in children: a study of prevalence and associated factors

Detalhes bibliográficos
Autor(a) principal: Wachholz, Neiva Isabel Raffo
Data de Publicação: 2007
Outros Autores: Ferreira, Jair
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192
Resumo: The survival of children with AIDS has increased considerably with the use of more effective antiretrovirals, but the benefits of this therapy are limited by the difficulty of adherence to the treatment. This cross-sectional study aimed to estimate the prevalence of non-adherence to antiretrovirals among children residents in Porto Alegre, Rio Grande do Sul State, Brazil, and identifying associated factors. There were 194 child caregivers interviewed. The technique utilized to evaluate adherence allowed the detection of lack of understanding of the prescribed antiretroviral regimens, as well as conscious loss of doses. Non-adherence was defined when the child had taken less than 80% of the prescribed medication during the 24h period prior to the interview. A general prevalence of non-adherence was 49.5%, which was higher than that estimated. The non-institutional caregivers had a prevalence rate of 55.7%, while the institutional caregivers had 22.2%. In multivariate analysis, the education of the caregiver was found to have a borderline association with the outcome. Institutionalized children and those taken care of by people with a higher educational level appeared to have more protection against non-adherence to antiretroviral therapy.
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spelling Adherence to antiretroviral therapy in children: a study of prevalence and associated factorsAnti-Retroviral AgentsAcquired Immunodeficiency SyndromeHIVChildThe survival of children with AIDS has increased considerably with the use of more effective antiretrovirals, but the benefits of this therapy are limited by the difficulty of adherence to the treatment. This cross-sectional study aimed to estimate the prevalence of non-adherence to antiretrovirals among children residents in Porto Alegre, Rio Grande do Sul State, Brazil, and identifying associated factors. There were 194 child caregivers interviewed. The technique utilized to evaluate adherence allowed the detection of lack of understanding of the prescribed antiretroviral regimens, as well as conscious loss of doses. Non-adherence was defined when the child had taken less than 80% of the prescribed medication during the 24h period prior to the interview. A general prevalence of non-adherence was 49.5%, which was higher than that estimated. The non-institutional caregivers had a prevalence rate of 55.7%, while the institutional caregivers had 22.2%. In multivariate analysis, the education of the caregiver was found to have a borderline association with the outcome. Institutionalized children and those taken care of by people with a higher educational level appeared to have more protection against non-adherence to antiretroviral therapy.A sobrevida de crianças com AIDS teve um aumento considerável com o emprego de anti-retrovirais mais efetivos, porém os benefícios dessa terapêutica são limitados pela dificuldade na adesão ao tratamento. Este estudo transversal teve como objetivo estimar a prevalência da não-adesão aos anti-retrovirais entre crianças residentes em Porto Alegre, Rio Grande do Sul, Brasil, e identificar os fatores associados. Foram entrevistados 194 cuidadores de crianças. A técnica utilizada para aferir a adesão permitiu detectar tanto as perdas por falhas no entendimento do esquema anti-retroviral prescrito quanto das perdas conscientes de doses. Foi definida como não-aderente a criança que ingeriu menos de 80% das doses prescritas para 24 horas no dia anterior à entrevista. A prevalência geral da não-adesão encontrada foi de 49,5% superior à estimada. Considerando os tipos de cuidadores não-institucionais e institucionais, no primeiro, a prevalência foi de 55,7% e, no segundo, de 22,2%. Na análise multivariável, a escolaridade do cuidador apresentou associação limítrofe com o desfecho. As crianças institucionalizadas e as cuidadas por pessoas com melhor escolaridade parecem estar mais protegidas da não-adesão aos anti-retrovirais.Reports in Public HealthCadernos de Saúde Pública2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192Reports in Public Health; Vol. 23 No. 15 (2007): Supplement 3Cadernos de Saúde Pública; v. 23 n. 15 (2007): Suplemento 31678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192/6448https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192/6449Wachholz, Neiva Isabel RaffoFerreira, Jairinfo:eu-repo/semantics/openAccess2024-03-06T15:27:27Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/3192Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:03:42.907718Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
title Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
spellingShingle Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
Wachholz, Neiva Isabel Raffo
Anti-Retroviral Agents
Acquired Immunodeficiency Syndrome
HIV
Child
title_short Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
title_full Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
title_fullStr Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
title_full_unstemmed Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
title_sort Adherence to antiretroviral therapy in children: a study of prevalence and associated factors
author Wachholz, Neiva Isabel Raffo
author_facet Wachholz, Neiva Isabel Raffo
Ferreira, Jair
author_role author
author2 Ferreira, Jair
author2_role author
dc.contributor.author.fl_str_mv Wachholz, Neiva Isabel Raffo
Ferreira, Jair
dc.subject.por.fl_str_mv Anti-Retroviral Agents
Acquired Immunodeficiency Syndrome
HIV
Child
topic Anti-Retroviral Agents
Acquired Immunodeficiency Syndrome
HIV
Child
description The survival of children with AIDS has increased considerably with the use of more effective antiretrovirals, but the benefits of this therapy are limited by the difficulty of adherence to the treatment. This cross-sectional study aimed to estimate the prevalence of non-adherence to antiretrovirals among children residents in Porto Alegre, Rio Grande do Sul State, Brazil, and identifying associated factors. There were 194 child caregivers interviewed. The technique utilized to evaluate adherence allowed the detection of lack of understanding of the prescribed antiretroviral regimens, as well as conscious loss of doses. Non-adherence was defined when the child had taken less than 80% of the prescribed medication during the 24h period prior to the interview. A general prevalence of non-adherence was 49.5%, which was higher than that estimated. The non-institutional caregivers had a prevalence rate of 55.7%, while the institutional caregivers had 22.2%. In multivariate analysis, the education of the caregiver was found to have a borderline association with the outcome. Institutionalized children and those taken care of by people with a higher educational level appeared to have more protection against non-adherence to antiretroviral therapy.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
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dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192/6448
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3192/6449
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dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 23 No. 15 (2007): Supplement 3
Cadernos de Saúde Pública; v. 23 n. 15 (2007): Suplemento 3
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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