Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438 |
Resumo: | We report on the first isolation of dengue virus serotype 4 (DENV-4) in the State of Mato Grosso do Sul, Brazil, in February, 2012. The cases were isolated in the city of Campo Grande, the state capital, and presented the classic signs and symptoms of dengue fever. DENV-4 was primarily identified through viral isolation in C6/36 clone lineage of Aedes albopictus cells; followed by indirect immunofluorescence, using type-specific monoclonal antibodies. The results were subsequently confirmed by Nested RT-PCR tests. The first description of the introduction of DENV-4 in a state whose population is susceptible to this serotype and the circulation of three other serotypes in the area is cause for concern due to the increased possibility of severe and lethal cases of the disease, and of huge epidemics. |
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Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, BrazilDengueDengue VirusCommunicable DiseasesWe report on the first isolation of dengue virus serotype 4 (DENV-4) in the State of Mato Grosso do Sul, Brazil, in February, 2012. The cases were isolated in the city of Campo Grande, the state capital, and presented the classic signs and symptoms of dengue fever. DENV-4 was primarily identified through viral isolation in C6/36 clone lineage of Aedes albopictus cells; followed by indirect immunofluorescence, using type-specific monoclonal antibodies. The results were subsequently confirmed by Nested RT-PCR tests. The first description of the introduction of DENV-4 in a state whose population is susceptible to this serotype and the circulation of three other serotypes in the area is cause for concern due to the increased possibility of severe and lethal cases of the disease, and of huge epidemics.Informe del primer aislamiento del serotipo del virus dengue 4 (DENV-4) en el Estado de Mato Grosso do Sul, Brasil, en febrero de 2012. Los casos fueron aislados en la ciudad de Campo Grande, capital del estado, y que presentan signos y síntomas de fiebre de dengue clásico. El DENV-4 se identificó principalmente a través de aislamiento viral en C6/36 con linaje de células de Aedes albopictus; seguido por inmunofluorescencia indirecta, utilizando anticuerpos monoclonales específicos de tipo. Después, fueron confirmados por pruebas de RT-PCR anidada. La descripción de la introducción del DENV-4 por primera vez en este estado, asociado a una población susceptible a este serotipo, y también la circulación de los otros tres serotipos en la zona es muy preocupante. La razón de esta preocupación es la mayor posibilidad de que se produzcan casos severos y letales de la enfermedad, así como, la aparición de grandes epidemias.Relatamos o primeiro isolamento do vírus dengue sorotipo 4 (DENV-4) no Estado de Mato Grosso do Sul, Brasil, em fevereiro de 2012. Os casos foram isolados na cidade de Campo Grande, capital do estado, e apresentaram sinais e sintomas clássicos da febre do dengue. O DENV-4 foi primeiramente identificado por isolamento viral em clone C6/36 linhagem de células de Aedes albopictus seguido por imunofluorescência indireta, utilizando anticorpos monoclonais tipo-específicos. Os resutlados foram posteriormente confirmados por testes de Nested RT-PCR. A descrição de sua introdução pela primeira vez neste estado, com população suscetível a este sorotipo e onde já circularam os outros três sorotipos é muito preocupante, pois aumenta a possibilidade de ocorrer formas graves e letais desta doença, assim como possibilita a ocorrência de grandes epidemias.Reports in Public HealthCadernos de Saúde Pública2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438Reports in Public Health; Vol. 30 No. 8 (2014): AugustCadernos de Saúde Pública; v. 30 n. 8 (2014): Agosto1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438/11190https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438/11191Lívia Garcia Bertolacci-RochaRivaldo Venâncio da CunhaGislene Garcia de Castro LichsMárcia Maria Ferrairo Janini Dal FabbroAna Rita Coimbra Motta-Castroinfo:eu-repo/semantics/openAccess2024-03-06T15:28:43Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/5438Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:06:15.162404Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
dc.title.none.fl_str_mv |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil |
title |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil |
spellingShingle |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil Lívia Garcia Bertolacci-Rocha Dengue Dengue Virus Communicable Diseases |
title_short |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil |
title_full |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil |
title_fullStr |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil |
title_full_unstemmed |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil |
title_sort |
Introduction of the dengue virus type 4 in the State of Mato Grosso do Sul, Brazil |
author |
Lívia Garcia Bertolacci-Rocha |
author_facet |
Lívia Garcia Bertolacci-Rocha Rivaldo Venâncio da Cunha Gislene Garcia de Castro Lichs Márcia Maria Ferrairo Janini Dal Fabbro Ana Rita Coimbra Motta-Castro |
author_role |
author |
author2 |
Rivaldo Venâncio da Cunha Gislene Garcia de Castro Lichs Márcia Maria Ferrairo Janini Dal Fabbro Ana Rita Coimbra Motta-Castro |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lívia Garcia Bertolacci-Rocha Rivaldo Venâncio da Cunha Gislene Garcia de Castro Lichs Márcia Maria Ferrairo Janini Dal Fabbro Ana Rita Coimbra Motta-Castro |
dc.subject.por.fl_str_mv |
Dengue Dengue Virus Communicable Diseases |
topic |
Dengue Dengue Virus Communicable Diseases |
description |
We report on the first isolation of dengue virus serotype 4 (DENV-4) in the State of Mato Grosso do Sul, Brazil, in February, 2012. The cases were isolated in the city of Campo Grande, the state capital, and presented the classic signs and symptoms of dengue fever. DENV-4 was primarily identified through viral isolation in C6/36 clone lineage of Aedes albopictus cells; followed by indirect immunofluorescence, using type-specific monoclonal antibodies. The results were subsequently confirmed by Nested RT-PCR tests. The first description of the introduction of DENV-4 in a state whose population is susceptible to this serotype and the circulation of three other serotypes in the area is cause for concern due to the increased possibility of severe and lethal cases of the disease, and of huge epidemics. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438 |
url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438/11190 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5438/11191 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 30 No. 8 (2014): August Cadernos de Saúde Pública; v. 30 n. 8 (2014): Agosto 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
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1798943376059400192 |