Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil

Detalhes bibliográficos
Autor(a) principal: Turchi, Marília Dalva
Data de Publicação: 2007
Outros Autores: Duarte, Lucélia da Silva, Martelli, Celina Maria Turchi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189
Resumo: The objectives of this study were to estimate the risk of vertical HIV transmission and assess the associated factors and missed opportunities for prevention in a cohort of HIV+ pregnant women (1995-2001) treated in Goiânia, Goiás, Brazil, with follow-up of their children until 2005. Three data sources were compared: Information System on Reportable Diseases (SINAN), Information System on HIV+ Pregnant Women and Exposed Children (SISGHIV), and patient clinical charts. The study estimated the vertical transmission rates, factors associated with vertical transmission, and use of antiretroviral therapy. 276 HIV+ women were identified (322 pregnancies), and there were 70 HIV+ children. Overall risk of vertical HIV transmission was 27.8%. The vertical transmission rate was 40.8% in the group without prophylaxis and 1% in the group with adequate prophylaxis, i.e., a 97.5% reduction in transmission risk. Year of delivery, consultation with a specialist, and no history of injecting drug use were factors associated with adequate use of antiretroviral therapy. The study showed an important reduction in the risk of vertical transmission in pregnant women who received adequate therapy, besides identifying missed opportunities for prevention.
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spelling Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, BrazilVertical Disease TransmissionHIVPregnancyThe objectives of this study were to estimate the risk of vertical HIV transmission and assess the associated factors and missed opportunities for prevention in a cohort of HIV+ pregnant women (1995-2001) treated in Goiânia, Goiás, Brazil, with follow-up of their children until 2005. Three data sources were compared: Information System on Reportable Diseases (SINAN), Information System on HIV+ Pregnant Women and Exposed Children (SISGHIV), and patient clinical charts. The study estimated the vertical transmission rates, factors associated with vertical transmission, and use of antiretroviral therapy. 276 HIV+ women were identified (322 pregnancies), and there were 70 HIV+ children. Overall risk of vertical HIV transmission was 27.8%. The vertical transmission rate was 40.8% in the group without prophylaxis and 1% in the group with adequate prophylaxis, i.e., a 97.5% reduction in transmission risk. Year of delivery, consultation with a specialist, and no history of injecting drug use were factors associated with adequate use of antiretroviral therapy. The study showed an important reduction in the risk of vertical transmission in pregnant women who received adequate therapy, besides identifying missed opportunities for prevention.Os objetivos foram estimar o risco de transmissão vertical do HIV e avaliar fatores associados e perdas de oportunidades de prevenção em coorte de gestantes HIV+ (1995-2001), atendidas em Goiânia, Goiás, Brasil, com seguimento das crianças até 2005. Foi realizada conciliação de três fontes de dados: Sistema de Informação de Agravos de Notificação (SINAN), Sistema de Informação de Gestantes HIV Positivas e Crianças Expostas (SISGHIV) e prontuários médicos. Foram estimados os percentuais de transmissão vertical, fatores associados à transmissão vertical e ao uso de terapia anti-retroviral. Foram identificadas 276 mulheres HIV+ (322 gestações) e os desfechos foram 70 crianças HIV+. O risco de transmissão vertical do HIV foi de 27,8%. A transmissão vertical foi de 40,8% no grupo sem profilaxia e de 1% no grupo com profilaxia adequada, com 97,5% de redução do risco de transmissão. Ano do parto, consulta com especialista e não ter antecedentes de drogas injetáveis foram fatores associados ao uso adequado de terapia anti-retroviral. O estudo evidenciou importante redução do risco de transmissão vertical em gestantes que receberam terapia adequada e identificou oportunidades perdidas para prevenção.Reports in Public HealthCadernos de Saúde Pública2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189Reports in Public Health; Vol. 23 No. 15 (2007): Supplement 3Cadernos de Saúde Pública; v. 23 n. 15 (2007): Suplemento 31678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189/6442https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189/6443Turchi, Marília DalvaDuarte, Lucélia da SilvaMartelli, Celina Maria Turchiinfo:eu-repo/semantics/openAccess2024-03-06T15:27:27Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/3189Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:03:42.718993Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
title Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
spellingShingle Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
Turchi, Marília Dalva
Vertical Disease Transmission
HIV
Pregnancy
title_short Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
title_full Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
title_fullStr Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
title_full_unstemmed Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
title_sort Mother-to-child transmission of HIV: risk factors and missed opportunities for prevention among pregnant women attending health services in Goiânia, Goiás State, Brazil
author Turchi, Marília Dalva
author_facet Turchi, Marília Dalva
Duarte, Lucélia da Silva
Martelli, Celina Maria Turchi
author_role author
author2 Duarte, Lucélia da Silva
Martelli, Celina Maria Turchi
author2_role author
author
dc.contributor.author.fl_str_mv Turchi, Marília Dalva
Duarte, Lucélia da Silva
Martelli, Celina Maria Turchi
dc.subject.por.fl_str_mv Vertical Disease Transmission
HIV
Pregnancy
topic Vertical Disease Transmission
HIV
Pregnancy
description The objectives of this study were to estimate the risk of vertical HIV transmission and assess the associated factors and missed opportunities for prevention in a cohort of HIV+ pregnant women (1995-2001) treated in Goiânia, Goiás, Brazil, with follow-up of their children until 2005. Three data sources were compared: Information System on Reportable Diseases (SINAN), Information System on HIV+ Pregnant Women and Exposed Children (SISGHIV), and patient clinical charts. The study estimated the vertical transmission rates, factors associated with vertical transmission, and use of antiretroviral therapy. 276 HIV+ women were identified (322 pregnancies), and there were 70 HIV+ children. Overall risk of vertical HIV transmission was 27.8%. The vertical transmission rate was 40.8% in the group without prophylaxis and 1% in the group with adequate prophylaxis, i.e., a 97.5% reduction in transmission risk. Year of delivery, consultation with a specialist, and no history of injecting drug use were factors associated with adequate use of antiretroviral therapy. The study showed an important reduction in the risk of vertical transmission in pregnant women who received adequate therapy, besides identifying missed opportunities for prevention.
publishDate 2007
dc.date.none.fl_str_mv 2007-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189/6442
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/3189/6443
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
application/pdf
dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 23 No. 15 (2007): Supplement 3
Cadernos de Saúde Pública; v. 23 n. 15 (2007): Suplemento 3
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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