PAH biomarkers for human health risk assessment: a review of the state-of-the-art

Detalhes bibliográficos
Autor(a) principal: Franco,Sérgio Silveira
Data de Publicação: 2008
Outros Autores: Nardocci,Adelaide Cássia, Günther,Wanda Maria Risso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600009
Resumo: Polycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers for human health risk assessment and also discusses their applicability within the context of environmental management in Brazil. The article discusses the methodologies for determination of some biomarkers such as 1-hydroxypyrene and PAH-DNA adducts. Cytogenetic markers, frequency of chromosomal aberrations, and micronucleus induction were considered for the evaluation of cancer risk. The current stage of studies on validation of such biomarkers was also approached.
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spelling PAH biomarkers for human health risk assessment: a review of the state-of-the-artAromatic Polycyclic HydrocarbonsBiological MarkersRisk AssessmentPolycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers for human health risk assessment and also discusses their applicability within the context of environmental management in Brazil. The article discusses the methodologies for determination of some biomarkers such as 1-hydroxypyrene and PAH-DNA adducts. Cytogenetic markers, frequency of chromosomal aberrations, and micronucleus induction were considered for the evaluation of cancer risk. The current stage of studies on validation of such biomarkers was also approached.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600009Cadernos de Saúde Pública v.24 suppl.4 2008reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X2008001600009info:eu-repo/semantics/openAccessFranco,Sérgio SilveiraNardocci,Adelaide CássiaGünther,Wanda Maria Rissoeng2008-09-02T00:00:00Zoai:scielo:S0102-311X2008001600009Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2008-09-02T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv PAH biomarkers for human health risk assessment: a review of the state-of-the-art
title PAH biomarkers for human health risk assessment: a review of the state-of-the-art
spellingShingle PAH biomarkers for human health risk assessment: a review of the state-of-the-art
Franco,Sérgio Silveira
Aromatic Polycyclic Hydrocarbons
Biological Markers
Risk Assessment
title_short PAH biomarkers for human health risk assessment: a review of the state-of-the-art
title_full PAH biomarkers for human health risk assessment: a review of the state-of-the-art
title_fullStr PAH biomarkers for human health risk assessment: a review of the state-of-the-art
title_full_unstemmed PAH biomarkers for human health risk assessment: a review of the state-of-the-art
title_sort PAH biomarkers for human health risk assessment: a review of the state-of-the-art
author Franco,Sérgio Silveira
author_facet Franco,Sérgio Silveira
Nardocci,Adelaide Cássia
Günther,Wanda Maria Risso
author_role author
author2 Nardocci,Adelaide Cássia
Günther,Wanda Maria Risso
author2_role author
author
dc.contributor.author.fl_str_mv Franco,Sérgio Silveira
Nardocci,Adelaide Cássia
Günther,Wanda Maria Risso
dc.subject.por.fl_str_mv Aromatic Polycyclic Hydrocarbons
Biological Markers
Risk Assessment
topic Aromatic Polycyclic Hydrocarbons
Biological Markers
Risk Assessment
description Polycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers for human health risk assessment and also discusses their applicability within the context of environmental management in Brazil. The article discusses the methodologies for determination of some biomarkers such as 1-hydroxypyrene and PAH-DNA adducts. Cytogenetic markers, frequency of chromosomal aberrations, and micronucleus induction were considered for the evaluation of cancer risk. The current stage of studies on validation of such biomarkers was also approached.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-311X2008001600009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
dc.source.none.fl_str_mv Cadernos de Saúde Pública v.24 suppl.4 2008
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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