Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis

Detalhes bibliográficos
Autor(a) principal: Dilvania Nicoletti
Data de Publicação: 2014
Outros Autores: Leilane Droppa Appel, Pedro Siedersberger Neto, Gabriel Waihrich Guimarães, Linjie Zhang
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504
Resumo: This systematic review aimed to investigate the association between maternal smoking during pregnancy and birth defects in children. We performed an electronic search of observational studies in the databases ovid MEDLINE (1950 to April 2010), LILACS and SciELO. We included 188 studies with a total of 13,564,914 participants (192,655 cases). Significant positive associations were found between maternal smoking and birth defects in the following body systems: cardiovascular (OR: 1.11; 95%CI: 1.03-1.19), digestive (OR: 1.18; 95%CI: 1.07-1.30), musculoskeletal (OR: 1.27; 95%CI: 1.16-1.39) and face and neck (OR: 1.28; 95%CI: 1.19-1.37). The strength of association between maternal smoking and birth defects measured by the OR (95%CI) is significantly related to the amount of cigarettes smoked daily (χ2 = 12.1; df = 2; p = 0.002). In conclusion, maternal smoking during pregnancy is associated with congenital malformations in children and this association is dose-dependent.
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spelling Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysisTabagismo materno na gestação e malformações congênitas em crianças: uma revisão sistemática com meta-análiseSmokingPregnancyCongenital AbnormalitiesHábito de FumarGravidezAnormalidades CongênitasThis systematic review aimed to investigate the association between maternal smoking during pregnancy and birth defects in children. We performed an electronic search of observational studies in the databases ovid MEDLINE (1950 to April 2010), LILACS and SciELO. We included 188 studies with a total of 13,564,914 participants (192,655 cases). Significant positive associations were found between maternal smoking and birth defects in the following body systems: cardiovascular (OR: 1.11; 95%CI: 1.03-1.19), digestive (OR: 1.18; 95%CI: 1.07-1.30), musculoskeletal (OR: 1.27; 95%CI: 1.16-1.39) and face and neck (OR: 1.28; 95%CI: 1.19-1.37). The strength of association between maternal smoking and birth defects measured by the OR (95%CI) is significantly related to the amount of cigarettes smoked daily (χ2 = 12.1; df = 2; p = 0.002). In conclusion, maternal smoking during pregnancy is associated with congenital malformations in children and this association is dose-dependent.Esta revisión sistemática se encargó de investigar la asociación entre el tabaquismo materno durante el embarazo y las malformaciones congénitas en los niños. Se realizó una búsqueda electrónica de los estudios de observación en las bases de datos de ovid MEDLINE (1950 hasta abril de 2010), LILACS y SciELO. 188 estudios con 13.564.914 participantes se incluyeron en esta revisión. Se encontraron asociaciones positivas significativas entre el tabaquismo materno y malformaciones de los sistemas: cardiovascular (OR: 1,11; IC95%: 1.03-1.19), digestivo (OR: 1,18; IC95%: 1,07-1,30), musculoesqueléticos (OR: 1,27; IC95%: 1,16-1,39) y de cara y cuello (OR: 1,28; IC95%: 1,19-1,37). La fuerza de la asociación entre el tabaquismo materno y los defectos de nacimiento, medidos por el OR (IC95%) está significativamente relacionada con la cantidad de cigarrillos fumados diariamente (χ2 = 12,1; p = 0,002). Llegamos a la conclusión de que el tabaquismo materno durante el embarazo se asocia con un mayor riesgo de malformaciones congénitas en los niños y esta asociación es dosis-dependiente.Esta revisão sistemática teve como objetivo investigar a associação entre fumo materno na gestação e as malformações congênitas em crianças. Uma busca eletrônica dos estudos observacionais foi realizada nas bases de dados ovid MEDLINE (1950 até abril de 2010), SciELO e LILACS. Foram incluídos nesta revisão 188 estudos com um total de 13.564.914 participantes (192.655 casos). Foram encontradas associações positivas significativas entre fumo materno e malformações dos sistemas: cardiovascular (OR: 1,11; IC95%: 1,03-1,19), digestivo (OR: 1,18; IC95%: 1,07-1,30), musculoesquelético (OR: 1,27; IC95%: 1,16-1,39) e face e pescoço (OR: 1,28; IC95%: 1,19-1,37). A força de associação entre fumo materno e malformações medida pelo OR (IC95%) está relacionada significativamente com a quantidade diária de cigarros consumidos (χ2 = 12,1; df = 2; p = 0,002). Concluímos que fumo materno na gestação está associado com maior risco de malformações congênitas em crianças e essa associação é dose-dependente.Reports in Public HealthCadernos de Saúde Pública2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmltext/htmlapplication/pdfapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504Reports in Public Health; Vol. 30 No. 12 (2014): DecemberCadernos de Saúde Pública; v. 30 n. 12 (2014): Dezembro1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZengporhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11386https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11387https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11388https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11389Dilvania NicolettiLeilane Droppa AppelPedro Siedersberger NetoGabriel Waihrich GuimarãesLinjie Zhanginfo:eu-repo/semantics/openAccess2024-03-06T15:28:46Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/5504Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:06:19.588948Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
Tabagismo materno na gestação e malformações congênitas em crianças: uma revisão sistemática com meta-análise
title Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
spellingShingle Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
Dilvania Nicoletti
Smoking
Pregnancy
Congenital Abnormalities
Hábito de Fumar
Gravidez
Anormalidades Congênitas
title_short Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
title_full Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
title_fullStr Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
title_full_unstemmed Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
title_sort Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis
author Dilvania Nicoletti
author_facet Dilvania Nicoletti
Leilane Droppa Appel
Pedro Siedersberger Neto
Gabriel Waihrich Guimarães
Linjie Zhang
author_role author
author2 Leilane Droppa Appel
Pedro Siedersberger Neto
Gabriel Waihrich Guimarães
Linjie Zhang
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Dilvania Nicoletti
Leilane Droppa Appel
Pedro Siedersberger Neto
Gabriel Waihrich Guimarães
Linjie Zhang
dc.subject.por.fl_str_mv Smoking
Pregnancy
Congenital Abnormalities
Hábito de Fumar
Gravidez
Anormalidades Congênitas
topic Smoking
Pregnancy
Congenital Abnormalities
Hábito de Fumar
Gravidez
Anormalidades Congênitas
description This systematic review aimed to investigate the association between maternal smoking during pregnancy and birth defects in children. We performed an electronic search of observational studies in the databases ovid MEDLINE (1950 to April 2010), LILACS and SciELO. We included 188 studies with a total of 13,564,914 participants (192,655 cases). Significant positive associations were found between maternal smoking and birth defects in the following body systems: cardiovascular (OR: 1.11; 95%CI: 1.03-1.19), digestive (OR: 1.18; 95%CI: 1.07-1.30), musculoskeletal (OR: 1.27; 95%CI: 1.16-1.39) and face and neck (OR: 1.28; 95%CI: 1.19-1.37). The strength of association between maternal smoking and birth defects measured by the OR (95%CI) is significantly related to the amount of cigarettes smoked daily (χ2 = 12.1; df = 2; p = 0.002). In conclusion, maternal smoking during pregnancy is associated with congenital malformations in children and this association is dose-dependent.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11386
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11387
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11388
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/5504/11389
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
text/html
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 30 No. 12 (2014): December
Cadernos de Saúde Pública; v. 30 n. 12 (2014): Dezembro
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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