Platelet-rich fibrin: preparation, quality definition, clinical use

• Autor(a) principal: Takamori, Esther Rieko
• Data de Publicação: 2018
• Outros Autores: Teixeira, Marcus Vinicius Telles, Menezes, Karla, Carias, Rosana Bizon Vieira, Borojevic, Radovan
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: Vigilância Sanitária em Debate
• Texto Completo: https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1044
• topic: Plaquetas; Fibrina; Regeneração; Cirurgia Bucal

Introduction: Platelet Rich Fibrin is a platelet concentrate, extemporaneously prepared and autologous, whose purpose is to improve and accelerate the cicatrizing and repair of surgical lesions, originally used for oral surgeries. Objective: To analyze the preparation, quality control and clinical use of PRF, to understand and discuss the practical and regulatory aspects of its use. Method: This work was elaborated as an integrative review, by the survey of scientific articles and current legislation on the clinical use of PRF. Results: PRF consists of a matrix of fibrin with a large quantity of platelets, which release numerous pro-regenerative mediators. Its preparation is done in a surgical center or dental office, and the dental surgeon is responsible for the procedures and the final product. The used equipment and materials must be compatible with the standards approved for the PRF preparation methods. Conclusion: The use of the PRF by dental surgeons is regulated by the Resolution of the Federal Council of Dentistry (CFO) 158/2015, June 08, 2015. There is no regulation for the use of PRF by the Federal Council of Medicine (CFM). PRF preparation and use are not considered to be a part of Advanced Therapies.