Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity

Detalhes bibliográficos
Autor(a) principal: Friedrich, Karen
Data de Publicação: 2013
Tipo de documento: Artigo
Idioma: por
Título da fonte: Vigilância Sanitária em Debate
Texto Completo: https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/30
Resumo: Intense usage of pesticides in Brazil poses a risk concerning arising of various and hazardously toxic effects such as towards to immunological and endocrine systems. Assays recommended by national and international guidelines possess limitations to perform a complete predictive evaluation of the broad spectrum of molecules and target-organs by pesticides with those properties.On the other hand interactions among immunological, endocrine and nervous systems difficult investigation of those hazards that may impact reproduction, metabolic processes, host resistance to pathogens and tumoral cells. Similar to drugs, a periodic licensing review of pesticides in Brazil must be adopted in urgent character in order to identify and ban de usage of health extremely hazardous pesticides. Although prescribed in law, licensing review demanded by health and environmental agencies is oftenly judicialized, preventing or delaying conclusion in several years. It is also upon demand a governmental policy regarding a transition from the current production model tied to agrobusiness to a production of agroecological basis.
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spelling Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicityDesafios para a avaliação toxicológica de agrotóxicos no Brasil: desregulação endócrina e imunotoxicidadeimmunotoxicityrisk assessmentendocrine disruptionpesticidesimunotoxicidadeavaliação do riscodesregulação endócrinaagrotóxicosIntense usage of pesticides in Brazil poses a risk concerning arising of various and hazardously toxic effects such as towards to immunological and endocrine systems. Assays recommended by national and international guidelines possess limitations to perform a complete predictive evaluation of the broad spectrum of molecules and target-organs by pesticides with those properties.On the other hand interactions among immunological, endocrine and nervous systems difficult investigation of those hazards that may impact reproduction, metabolic processes, host resistance to pathogens and tumoral cells. Similar to drugs, a periodic licensing review of pesticides in Brazil must be adopted in urgent character in order to identify and ban de usage of health extremely hazardous pesticides. Although prescribed in law, licensing review demanded by health and environmental agencies is oftenly judicialized, preventing or delaying conclusion in several years. It is also upon demand a governmental policy regarding a transition from the current production model tied to agrobusiness to a production of agroecological basis.O uso intensivo de agrotóxicos no Brasil impõe o risco do aparecimento de efeitos tóxicos diversos e altamente deletérios, como os efeitos sobre o sistema imunológico e endócrino. Os testes preconizados pelas diretrizes nacionais e internacionais possuem limitações para uma avaliação preditiva completa do amplo espectro de moléculas, receptores, células e órgãos-alvo dos agrotóxicos com essas propriedades. Além disso, a interação entre os sistemas nervoso, endócrino e imunológico acaba por dificultar o estudo desses efeitos que podem impactar a reprodução, processos metabólicos e a resistência a patógenos e o combate a tumores. A exemplo do que ocorre com medicamentos, a revisão periódica do registro de agrotóxicos no Brasil deve ser adotada em caráter urgente para identificar e proibir o uso de agrotóxicos que sejam extremamente danosos à saúde. Apesar de prevista na lei, a revisão do registro demandada pelos órgãos da saúde e do meio ambiente passa por processo de judicialização, impedindo ou atrasando em vários anos a sua conclusão. Também se mostra urgente uma política governamental para a transição do atual modelo de produção vinculado ao agronegócio para um de produção de base agroecológica.Instituto Nacional de Controle de Qualidade em Saúde2013-05-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Peer-reviewed article""Artículo revisado por pares""Artigo avaliado pelos pares"application/pdfhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/3010.3395/vd.v1n2.30Health Surveillance under Debate: Society, Science & Technology ; Vol. 1 No. 2 (2013): May; 2-15Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 1 Núm. 2 (2013): Puede; 2-15Vigil Sanit Debate, Rio de Janeiro; v. 1 n. 2 (2013): Maio; 2-152317-269Xreponame:Vigilância Sanitária em Debateinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/30/34Copyright (c) 2013 Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology) – Visa em Debatehttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessFriedrich, Karen2023-06-27T14:55:08Zoai:ojs.visaemdebate.incqs.fiocruz.br:article/30Revistahttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebatePUBhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/oaiincqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br2317-269X2317-269Xopendoar:2023-06-27T14:55:08Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
Desafios para a avaliação toxicológica de agrotóxicos no Brasil: desregulação endócrina e imunotoxicidade
title Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
spellingShingle Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
Friedrich, Karen
immunotoxicity
risk assessment
endocrine disruption
pesticides
imunotoxicidade
avaliação do risco
desregulação endócrina
agrotóxicos
title_short Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
title_full Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
title_fullStr Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
title_full_unstemmed Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
title_sort Challenges to toxicological evaluation of pesticides in Brazil: endocrine disruption and immunotoxicity
author Friedrich, Karen
author_facet Friedrich, Karen
author_role author
dc.contributor.author.fl_str_mv Friedrich, Karen
dc.subject.por.fl_str_mv immunotoxicity
risk assessment
endocrine disruption
pesticides
imunotoxicidade
avaliação do risco
desregulação endócrina
agrotóxicos
topic immunotoxicity
risk assessment
endocrine disruption
pesticides
imunotoxicidade
avaliação do risco
desregulação endócrina
agrotóxicos
description Intense usage of pesticides in Brazil poses a risk concerning arising of various and hazardously toxic effects such as towards to immunological and endocrine systems. Assays recommended by national and international guidelines possess limitations to perform a complete predictive evaluation of the broad spectrum of molecules and target-organs by pesticides with those properties.On the other hand interactions among immunological, endocrine and nervous systems difficult investigation of those hazards that may impact reproduction, metabolic processes, host resistance to pathogens and tumoral cells. Similar to drugs, a periodic licensing review of pesticides in Brazil must be adopted in urgent character in order to identify and ban de usage of health extremely hazardous pesticides. Although prescribed in law, licensing review demanded by health and environmental agencies is oftenly judicialized, preventing or delaying conclusion in several years. It is also upon demand a governmental policy regarding a transition from the current production model tied to agrobusiness to a production of agroecological basis.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
"Peer-reviewed article"
"Artículo revisado por pares"
"Artigo avaliado pelos pares"
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/30
10.3395/vd.v1n2.30
url https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/30
identifier_str_mv 10.3395/vd.v1n2.30
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/30/34
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
dc.source.none.fl_str_mv Health Surveillance under Debate: Society, Science & Technology ; Vol. 1 No. 2 (2013): May; 2-15
Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 1 Núm. 2 (2013): Puede; 2-15
Vigil Sanit Debate, Rio de Janeiro; v. 1 n. 2 (2013): Maio; 2-15
2317-269X
reponame:Vigilância Sanitária em Debate
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Vigilância Sanitária em Debate
collection Vigilância Sanitária em Debate
repository.name.fl_str_mv Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv incqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br
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