Epidemiology, toxicology, and environmental causes of diseases

Detalhes bibliográficos
Autor(a) principal: Paumgartten, Francisco José Roma
Data de Publicação: 2015
Tipo de documento: Artigo
Idioma: por
Título da fonte: Vigilância Sanitária em Debate
Texto Completo: https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/585
Resumo: This article discusses the methodological limitations of epidemiological and experimental studies when these studies are utilized to establish the causality between environmental and occupational exposures and diseases. The high probability of non-causal explanations for weak associations revealed by observational studies is emphasized; additionally, the consequences are revealed when weak associations are taken to guide public health interventions, to support diagnosis in occupational medicine and expert reports addressed to the court, and to communicate risks. Shortcomings of risk estimations based only on the evidence from experimental toxicology studies are discussed. Uncertainties involved in extrapolating toxicological findings between species and the relevance of taking into account the dose–response relationships and exposure levels experimented on human populations are also commented upon.
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spelling Epidemiology, toxicology, and environmental causes of diseasesEpidemiologia, toxicologia e causalidade ambiental de doençasEtiologiaMétodos EpidemiológicosNeoplasiasDoenças ProfissionaisPoluição AmbientalEtiologyEpidemiologic MethodsNeoplasmsOccupational DiseasesEnvironmental PollutionThis article discusses the methodological limitations of epidemiological and experimental studies when these studies are utilized to establish the causality between environmental and occupational exposures and diseases. The high probability of non-causal explanations for weak associations revealed by observational studies is emphasized; additionally, the consequences are revealed when weak associations are taken to guide public health interventions, to support diagnosis in occupational medicine and expert reports addressed to the court, and to communicate risks. Shortcomings of risk estimations based only on the evidence from experimental toxicology studies are discussed. Uncertainties involved in extrapolating toxicological findings between species and the relevance of taking into account the dose–response relationships and exposure levels experimented on human populations are also commented upon.O artigo analisa o estabelecimento de nexos causais entre exposições ambientais e ocupacionais e doenças a partir das evidências epidemiológicas e experimentais. A alta probabilidade de explicações não causais para associações fracas encontradas por estudos observacionais é enfatizada, assim como as suas implicações para nortear intervenções em Saúde Pública, subsidiar diagnósticos de causalidade em Medicina do trabalho e perícias legais, e comunicação do risco. As limitações da estimativa do risco a partir unicamente das evidencias toxicológicas são comentadas, com destaque para a incerteza que cerca a extrapolação entre espécies, e a necessidade de levar em conta a relação dose-resposta e os níveis de exposição experimentados pelas populações humanas.Instituto Nacional de Controle de Qualidade em Saúde2015-05-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Peer-reviewed article""Artículo revisado por pares""Artigo avaliado pelos pares"application/pdfhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/58510.3395/2317-269x.00585Health Surveillance under Debate: Society, Science & Technology ; Vol. 3 No. 2 (2015): May; 3-8Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 3 Núm. 2 (2015): Puede; 3-8Vigil Sanit Debate, Rio de Janeiro; v. 3 n. 2 (2015): Maio; 3-82317-269Xreponame:Vigilância Sanitária em Debateinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/585/232Copyright (c) 2015 Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology) – Visa em Debatehttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessPaumgartten, Francisco José Roma2023-06-27T14:59:48Zoai:ojs.visaemdebate.incqs.fiocruz.br:article/585Revistahttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebatePUBhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/oaiincqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br2317-269X2317-269Xopendoar:2023-06-27T14:59:48Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Epidemiology, toxicology, and environmental causes of diseases
Epidemiologia, toxicologia e causalidade ambiental de doenças
title Epidemiology, toxicology, and environmental causes of diseases
spellingShingle Epidemiology, toxicology, and environmental causes of diseases
Paumgartten, Francisco José Roma
Etiologia
Métodos Epidemiológicos
Neoplasias
Doenças Profissionais
Poluição Ambiental
Etiology
Epidemiologic Methods
Neoplasms
Occupational Diseases
Environmental Pollution
title_short Epidemiology, toxicology, and environmental causes of diseases
title_full Epidemiology, toxicology, and environmental causes of diseases
title_fullStr Epidemiology, toxicology, and environmental causes of diseases
title_full_unstemmed Epidemiology, toxicology, and environmental causes of diseases
title_sort Epidemiology, toxicology, and environmental causes of diseases
author Paumgartten, Francisco José Roma
author_facet Paumgartten, Francisco José Roma
author_role author
dc.contributor.author.fl_str_mv Paumgartten, Francisco José Roma
dc.subject.por.fl_str_mv Etiologia
Métodos Epidemiológicos
Neoplasias
Doenças Profissionais
Poluição Ambiental
Etiology
Epidemiologic Methods
Neoplasms
Occupational Diseases
Environmental Pollution
topic Etiologia
Métodos Epidemiológicos
Neoplasias
Doenças Profissionais
Poluição Ambiental
Etiology
Epidemiologic Methods
Neoplasms
Occupational Diseases
Environmental Pollution
description This article discusses the methodological limitations of epidemiological and experimental studies when these studies are utilized to establish the causality between environmental and occupational exposures and diseases. The high probability of non-causal explanations for weak associations revealed by observational studies is emphasized; additionally, the consequences are revealed when weak associations are taken to guide public health interventions, to support diagnosis in occupational medicine and expert reports addressed to the court, and to communicate risks. Shortcomings of risk estimations based only on the evidence from experimental toxicology studies are discussed. Uncertainties involved in extrapolating toxicological findings between species and the relevance of taking into account the dose–response relationships and exposure levels experimented on human populations are also commented upon.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
"Peer-reviewed article"
"Artículo revisado por pares"
"Artigo avaliado pelos pares"
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/585
10.3395/2317-269x.00585
url https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/585
identifier_str_mv 10.3395/2317-269x.00585
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/585/232
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
dc.source.none.fl_str_mv Health Surveillance under Debate: Society, Science & Technology ; Vol. 3 No. 2 (2015): May; 3-8
Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 3 Núm. 2 (2015): Puede; 3-8
Vigil Sanit Debate, Rio de Janeiro; v. 3 n. 2 (2015): Maio; 3-8
2317-269X
reponame:Vigilância Sanitária em Debate
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Vigilância Sanitária em Debate
collection Vigilância Sanitária em Debate
repository.name.fl_str_mv Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv incqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br
_version_ 1797042044573581312

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