CLINICAL AND EPIDEMIOLOGICAL ANALYSIS OF LABIAL AND PALATIN FISSURES ASSOCIATED WITH OTHER DISMORPHIES IN THE MUNICIPALITY OF CAMPOS DOS GOYTACAZES

• Autor(a) principal: Ribeiro, João Marcos Marcelino Chaves
• Data de Publicação: 2017
• Outros Autores: Almeida, João Paulo Chevrand Latini de, Ferreira Júnior, Wellington dos Santos, Coutinho, Marcelo Paula, Pena, Igor Leal
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Científica da Faculdade de Medicina de Campos
• DOI: 10.29184/1980-7813.rcfmc.36.vol.12.n1.2017
• Texto Completo: https://www.fmc.br/ojs/index.php/RCFMC/article/view/36
• topic: congênitas; cariotipagem; malformação

The cleft lip and cleft palate (FL / P) is a congenital malformation, caused by a lack of fusion of the palate, resulting in an abnormal facial appearance and speech losses being included among the most common craniofacial anomalies studied by this research. Objective: Analyze an association of genetic dysmorphisms in the process of lip and cleft palate in patients treated at the genetic service of Campos dos Goytacazes by means of epidemiological data. Methods: This is an observational, documentary and cross-sectional study that evaluates a sample of patients served in CRTCA-2- Genetic Service using the medical record in the Datagenno database. Results: There was a prevalence of 1 case in 91 patients attended, predominantly in female compared to male (61.64% versus 38.36%). It was noticed an increase in incidence of 50% in cases occurring between 2013 and 2016. In addition, it evident the importance of family history and episodes of spontaneous abortion in 29.17% of mothers. Besides that, it was verified and Apgar alteration. There were also concomitants related in 53.85% of the cases and chromosomal changes in 87.5% of the subtopics to karyotyping as the gain in the 22q11.2 locus characteristic of the Velocardiofacial Syndrome.