SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction

Detalhes bibliográficos
Autor(a) principal: Pedro Toscano Paffer
Data de Publicação: 2022
Outros Autores: Isabelly Regina Bezerra de Albuquerque Cortez, Marcelo Danilo Damasso Lisboa Costa, Maria Rosália da Costa Neta, Marina Lins Tavares Pedroza Monteiro, Vitória Maria Terra Lopes, Silvio Hock de Paffer Filho
Tipo de documento: Artigo
Idioma: por
Título da fonte: Anais da Faculdade de Medicina de Olinda (Online)
Texto Completo: https://afmo.emnuvens.com.br/afmo/article/view/229
Resumo: Introduction: Heart failure (HF) is a clinical syndrome characterized by decreased left ventricular ejection fraction. The use of sodium-glucose transporter 2 inhibitors (ISGLT2) in patients with HF showed efficacy in reducing mortality and hospitalization.Methodology: A bibliographic survey was carried out in the main databases, analyzing the benefits of ISGLT2 in the main high-impact journals.Discussion: EMPAREG showed a lower mortality in the use of empaglifozin compared to the group that received the placebo (3.7% vs. 5.7%). The canagliflozin study, CANVAS, showed a 14% lower risk of cardiovascular death in patients without cardiovascular disease (CVD), whereas in patients with known CVD, it decreased by 18%. DECLARE-TIMI 58 showed that in patients with DM2 there is a lower risk of HF and death from cardiovascular events among patients who used Dapaglifozin compared to patients who received placebo (4.9% vs. 5.8). In DAPA HF, the number of deaths from cardiovascular causes was 9.7% vs 11.5% of patients who took placebo. In EMPEROR-REDUCED, with Empaglifozin, the primary endpoint occurred in 361 of 1863 patients (19.4%) in the drug group against 462 of 1867 patients (24.7%) in the placebo group. SOLOIST-WHF, analyzing the drug Sotagliflozin, observed the occurrence of a primary outcome in 245 patients in the drug group and 355 in the placebo group.Conclusion: Patients with HF have gained a new drug class for their treatment, being even mentioned in the most recent guidelines around the world, still needing more studies to test it efficacy in HF with preserved ejected fraction.
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spelling SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fractionInibidores SGLT-2 no tratamento da insuficiência cardíaca com fração de ejeção reduzida.Diabetes Mellitusinsuficiência cardíacadoenças cardiovasculares doença renal crônicamortalidadeDiabetes mellitusHeart FailureCardiovascular DiseasesRenal Insufficiency ChronicMortalityIntroduction: Heart failure (HF) is a clinical syndrome characterized by decreased left ventricular ejection fraction. The use of sodium-glucose transporter 2 inhibitors (ISGLT2) in patients with HF showed efficacy in reducing mortality and hospitalization.Methodology: A bibliographic survey was carried out in the main databases, analyzing the benefits of ISGLT2 in the main high-impact journals.Discussion: EMPAREG showed a lower mortality in the use of empaglifozin compared to the group that received the placebo (3.7% vs. 5.7%). The canagliflozin study, CANVAS, showed a 14% lower risk of cardiovascular death in patients without cardiovascular disease (CVD), whereas in patients with known CVD, it decreased by 18%. DECLARE-TIMI 58 showed that in patients with DM2 there is a lower risk of HF and death from cardiovascular events among patients who used Dapaglifozin compared to patients who received placebo (4.9% vs. 5.8). In DAPA HF, the number of deaths from cardiovascular causes was 9.7% vs 11.5% of patients who took placebo. In EMPEROR-REDUCED, with Empaglifozin, the primary endpoint occurred in 361 of 1863 patients (19.4%) in the drug group against 462 of 1867 patients (24.7%) in the placebo group. SOLOIST-WHF, analyzing the drug Sotagliflozin, observed the occurrence of a primary outcome in 245 patients in the drug group and 355 in the placebo group.Conclusion: Patients with HF have gained a new drug class for their treatment, being even mentioned in the most recent guidelines around the world, still needing more studies to test it efficacy in HF with preserved ejected fraction.Introdução: A insuficiência cardíaca (IC) é uma síndrome clínica caracterizada pela diminuição da fração de ejeção do ventrículo esquerdo. O uso dos inibidores do transportador de sódio-glicose 2 (ISGLT2) em portadores de IC, mostraram uma eficácia na diminuição de mortalidade e internação. Metodologia: Realizado levantamento bibliográfico nas principais bases de dados, analisando os benefícios do ISGLT2 nas principais revistas de alto impacto. Discussão: O EMPAREG mostrou menor mortalidade no uso de Empaglifozina comparando-se ao placebo (3,7% vs. 5,7%). O estudo da Canaglifozina, CANVAS, mostrou 14% menor de risco de morte cardiovascular em pacientes sem doença cardiovascular (DCV), em pacientes com DCV conhecida, diminuiu em 18%. O DECLARE-TIMI 58, evidenciou que pacientes com DM2 há menor risco de IC e morte por eventos cardiovasculares entre os pacientes que utilizaram a Dapaglifozina comparado ao placebo (4,9% vs. 5,8). No DAPA HF, o número de mortes por causa cardiovascular foi de 9,7% vs 11,5% dos pacientes que tomaram placebo. No EMPEROR-REDUCED, com Empaglifozina, o desfecho primário ocorreu em 361 dos 1863 pacientes (19.4%) no grupo que recebeu a droga e em 462 dos 1867 pacientes (24.7%) no grupo placebo. O SOLOIST-WHF, analisando a Sotaglifozina, observou a ocorrência de desfecho primário em 245 pacientes no grupo do medicamento contra 355 no grupo placebo. Conclusão: Os pacientes com IC ganharam uma nova opção para o seu tratamento, sendo inclusive, citada nas diretrizes mais recentes de todo o mundo, entretanto, ainda são necessários novos estudos para testar sua aplicabilidade na IC com fração de ejeção preservadaFaculdade de Medicina de Olinda2022-12-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://afmo.emnuvens.com.br/afmo/article/view/22910.56102/afmo.2022.229ANNALS OF OLINDA MEDICAL SCHOOL; Vol. 1 No. 8 (2022); 64-68Anais da Faculdade de Medicina de Olinda; v. 1 n. 8 (2022); 64-682674-84872595-1734reponame:Anais da Faculdade de Medicina de Olinda (Online)instname:Faculdade de Medicina de Olinda (FMO)instacron:FMOporhttps://afmo.emnuvens.com.br/afmo/article/view/229/126Copyright (c) 2022 Pedro Toscano Paffer, Isabelly Regina Bezerra de Albuquerque Cortez, Marcelo Danilo Damasso Lisboa Costa, Maria Rosália da Costa Neta, Marina Lins Tavares Pedroza Monteiro, Vitória Maria Terra Lopes, Silvio Hock de Paffer Filhohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPedro Toscano PafferIsabelly Regina Bezerra de Albuquerque CortezMarcelo Danilo Damasso Lisboa CostaMaria Rosália da Costa NetaMarina Lins Tavares Pedroza MonteiroVitória Maria Terra LopesSilvio Hock de Paffer Filho2022-12-23T01:56:05Zoai:ojs.afmo.emnuvens.com.br:article/229Revistahttps://afmo.emnuvens.com.br/afmoPUBhttps://afmo.emnuvens.com.br/afmo/oaianaisfmo@fmo.edu.br2674-84872595-1734opendoar:2022-12-23T01:56:05Anais da Faculdade de Medicina de Olinda (Online) - Faculdade de Medicina de Olinda (FMO)false
dc.title.none.fl_str_mv SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
Inibidores SGLT-2 no tratamento da insuficiência cardíaca com fração de ejeção reduzida.
title SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
spellingShingle SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
Pedro Toscano Paffer
Diabetes Mellitus
insuficiência cardíaca
doenças cardiovasculares
doença renal crônica
mortalidade
Diabetes mellitus
Heart Failure
Cardiovascular Diseases
Renal Insufficiency Chronic
Mortality
title_short SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
title_full SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
title_fullStr SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
title_full_unstemmed SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
title_sort SGLT-2 inhibitors in the treatment of heart failure with reduced ejection fraction
author Pedro Toscano Paffer
author_facet Pedro Toscano Paffer
Isabelly Regina Bezerra de Albuquerque Cortez
Marcelo Danilo Damasso Lisboa Costa
Maria Rosália da Costa Neta
Marina Lins Tavares Pedroza Monteiro
Vitória Maria Terra Lopes
Silvio Hock de Paffer Filho
author_role author
author2 Isabelly Regina Bezerra de Albuquerque Cortez
Marcelo Danilo Damasso Lisboa Costa
Maria Rosália da Costa Neta
Marina Lins Tavares Pedroza Monteiro
Vitória Maria Terra Lopes
Silvio Hock de Paffer Filho
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pedro Toscano Paffer
Isabelly Regina Bezerra de Albuquerque Cortez
Marcelo Danilo Damasso Lisboa Costa
Maria Rosália da Costa Neta
Marina Lins Tavares Pedroza Monteiro
Vitória Maria Terra Lopes
Silvio Hock de Paffer Filho
dc.subject.por.fl_str_mv Diabetes Mellitus
insuficiência cardíaca
doenças cardiovasculares
doença renal crônica
mortalidade
Diabetes mellitus
Heart Failure
Cardiovascular Diseases
Renal Insufficiency Chronic
Mortality
topic Diabetes Mellitus
insuficiência cardíaca
doenças cardiovasculares
doença renal crônica
mortalidade
Diabetes mellitus
Heart Failure
Cardiovascular Diseases
Renal Insufficiency Chronic
Mortality
description Introduction: Heart failure (HF) is a clinical syndrome characterized by decreased left ventricular ejection fraction. The use of sodium-glucose transporter 2 inhibitors (ISGLT2) in patients with HF showed efficacy in reducing mortality and hospitalization.Methodology: A bibliographic survey was carried out in the main databases, analyzing the benefits of ISGLT2 in the main high-impact journals.Discussion: EMPAREG showed a lower mortality in the use of empaglifozin compared to the group that received the placebo (3.7% vs. 5.7%). The canagliflozin study, CANVAS, showed a 14% lower risk of cardiovascular death in patients without cardiovascular disease (CVD), whereas in patients with known CVD, it decreased by 18%. DECLARE-TIMI 58 showed that in patients with DM2 there is a lower risk of HF and death from cardiovascular events among patients who used Dapaglifozin compared to patients who received placebo (4.9% vs. 5.8). In DAPA HF, the number of deaths from cardiovascular causes was 9.7% vs 11.5% of patients who took placebo. In EMPEROR-REDUCED, with Empaglifozin, the primary endpoint occurred in 361 of 1863 patients (19.4%) in the drug group against 462 of 1867 patients (24.7%) in the placebo group. SOLOIST-WHF, analyzing the drug Sotagliflozin, observed the occurrence of a primary outcome in 245 patients in the drug group and 355 in the placebo group.Conclusion: Patients with HF have gained a new drug class for their treatment, being even mentioned in the most recent guidelines around the world, still needing more studies to test it efficacy in HF with preserved ejected fraction.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://afmo.emnuvens.com.br/afmo/article/view/229
10.56102/afmo.2022.229
url https://afmo.emnuvens.com.br/afmo/article/view/229
identifier_str_mv 10.56102/afmo.2022.229
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://afmo.emnuvens.com.br/afmo/article/view/229/126
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Medicina de Olinda
publisher.none.fl_str_mv Faculdade de Medicina de Olinda
dc.source.none.fl_str_mv ANNALS OF OLINDA MEDICAL SCHOOL; Vol. 1 No. 8 (2022); 64-68
Anais da Faculdade de Medicina de Olinda; v. 1 n. 8 (2022); 64-68
2674-8487
2595-1734
reponame:Anais da Faculdade de Medicina de Olinda (Online)
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instname_str Faculdade de Medicina de Olinda (FMO)
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reponame_str Anais da Faculdade de Medicina de Olinda (Online)
collection Anais da Faculdade de Medicina de Olinda (Online)
repository.name.fl_str_mv Anais da Faculdade de Medicina de Olinda (Online) - Faculdade de Medicina de Olinda (FMO)
repository.mail.fl_str_mv anaisfmo@fmo.edu.br
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