Exogenous melatonin and its metabolic effects: literature review

• Autor(a) principal: Júnior, Paulo Roberto da Silva
• Data de Publicação: 2019
• Outros Autores: Cabral, Hianny Ribeiro, Ramos Gomes, André Luis Oliveira, Estevam Teófilo, Pedro Bruno, Beserra de Oliveira, Thárcia Kiara
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Anais da Faculdade de Medicina de Olinda (Online)
• Texto Completo: https://afmo.emnuvens.com.br/afmo/article/view/60
• topic: Efeitos. Melatonina. Regulação fisiológica.; Effects. Melatonin. Physiologicalregulation.

Introduction: Melatonin is a hormone produced mainly by the pineal gland and has direct action on the regulation of physiological processes, especiallythe circadian cycle. Aim: To demonstrate through the literature the different physiological effects related to the administration of exogenous melatonin. Methods: This is a descriptive and exploratory study, based on the summarization of recent works published in English or Portuguese. We analyzed andincluded 25 indexed articles in the databases Scielo, Pubmed, Science Direct and Cochrane. Comments: This hormone is directly involved in the regulation ofphysiological processes, such as the circadian cycle, immune and cardiovascular regulation, pro-oxidant and anti-oxidant activity and gastroprotection, in addition to having a neuroprotective and neuromodulatory effect. Conclusion: Melatonin is directly linked to positive effects in processes of themost diverse body systems. It is a safe and good tolerable molecule, being related to few side effects and not causing withdrawal symptoms.