Evidência de associação entre grupo sanguíneo O e rinite alérgica

Detalhes bibliográficos
Autor(a) principal: Falsarella, Nelson
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da FAMERP
Texto Completo: http://bdtd.famerp.br/handle/tede/510
Resumo: Allergic rhinitis is a disease characterized by inflammatory reactions of the upper airway tract which prevalence increased in the last decades. There are strong evidences that this disease is influenced by environmental and genetic factors. The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis (AR). 168 patients with AR and 168 controls from the same geographical region and paired by gender, and age were enrolled. ABO phenotypes were identified in the red blood cells using the hemagglutination technique. The Fisher exact and the chi-squared tests were employed to compare proportions (P < 0.05). The values of Odds ratio (OR) and confidence interval (CI) at 95% were also calculated. The overall differences in the frequencies of the ABO phenotypes from patients and controls were marginal (χ2: 7.569; DF: 3; P = 0.055), but the O blood group was associated with AR (χ2: 5.764; DF: 1; P: 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences on the frequencies of the O phenotype from patients and controls were statistically different for male (χ2: 8.520; DF: 1; P = 0.003) but not for female (χ2: 0.6375; DF: 1; P = 0.4246). Respectively, the A and O phenotypes were associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; P = 0.049) and susceptibility (OR = 2.789; CI 95%: 1.385-5.616; P = 0.005) to AR only for men. The O blood group phenotype is associated with AR in male but not in female patients.
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spelling Mattos, Luiz Carlos dehttp://lattes.cnpq.br/1355463443978857Moreira, Haroldo WilsonBarboza, Marcelo A. Ingraci07468174873http://lattes.cnpq.br/9344696862473232Falsarella, Nelson2019-02-15T17:23:47Z2012-04-19Falsarella, Nelson. Evidência de associação entre grupo sanguíneo O e rinite alérgica. 2012. 47 f. Dissertação (Programa de Pós-Graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.1085http://bdtd.famerp.br/handle/tede/510Allergic rhinitis is a disease characterized by inflammatory reactions of the upper airway tract which prevalence increased in the last decades. There are strong evidences that this disease is influenced by environmental and genetic factors. The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis (AR). 168 patients with AR and 168 controls from the same geographical region and paired by gender, and age were enrolled. ABO phenotypes were identified in the red blood cells using the hemagglutination technique. The Fisher exact and the chi-squared tests were employed to compare proportions (P < 0.05). The values of Odds ratio (OR) and confidence interval (CI) at 95% were also calculated. The overall differences in the frequencies of the ABO phenotypes from patients and controls were marginal (χ2: 7.569; DF: 3; P = 0.055), but the O blood group was associated with AR (χ2: 5.764; DF: 1; P: 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences on the frequencies of the O phenotype from patients and controls were statistically different for male (χ2: 8.520; DF: 1; P = 0.003) but not for female (χ2: 0.6375; DF: 1; P = 0.4246). Respectively, the A and O phenotypes were associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; P = 0.049) and susceptibility (OR = 2.789; CI 95%: 1.385-5.616; P = 0.005) to AR only for men. The O blood group phenotype is associated with AR in male but not in female patients.A rinite alérgica é uma doença caracterizada por inflamação das vias aéreas superiores, cuja prevalência cresceu nas últimas décadas. Há fortes evidências de que essa doença seja influenciada por fatores ambientais e genéticos. O objetivo deste estudo foi verificar se os fenótipos ABO estão associados à rinite alérgica (RA). Foram selecionados 168 pacientes com RA e 168 controles sem RA oriundos da mesma região geográfica, pareados por sexo e idade. Os fenótipos ABO foram identificados nos eritrócitos com o uso de método hemaglutinação. Os testes exato de Fisher e qui-quadrado foram empregados para comparar as proporções (p>0,05). Os valores de Odds Ratio e do Intervalo de Confiança (IC) a 95% também foram calculados. As frequências dos fenótipos ABO de pacientes e controles apresentaram diferenças marginais em relação ao nível de significância (χ2: 7.569; GL: 3; p = 0.055), mas o grupo O foi associado à RA (χ2: 5.764; DF: 1; p = 0.016; OR: 1.735; IC 95%: 1.127-2.673). As diferenças nas frequências do grupo O de pacientes e controles foram estatisticamente significantes para o sexo masculino (÷2: 8.520; GL: 1; p = 0.003) mas não para o feminino (χ2: 0.6375; GL: 1; p = 0.4246). Respectivamente, os grupos A e O foram associados à proteção (OR: 0.4385; IC 95%: 0.2043-0.9415; p = 0.049) e suscetibilidade (OR = 2.789; IC 95%: 1.385-5.616; p = 0.005) à RA somente no sexo masculino. O grupo O está associado à RA em pacientes do sexo masculino, mas não naqueles do sexo feminino.Submitted by Suzana Dias (suzana.dias@famerp.br) on 2019-02-15T17:23:46Z No. of bitstreams: 1 NelsonFalsarella_Dissert.pdf: 1152414 bytes, checksum: 026b1c2f541e895b8e087878925b9375 (MD5)Made available in DSpace on 2019-02-15T17:23:47Z (GMT). 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dc.title.por.fl_str_mv Evidência de associação entre grupo sanguíneo O e rinite alérgica
title Evidência de associação entre grupo sanguíneo O e rinite alérgica
spellingShingle Evidência de associação entre grupo sanguíneo O e rinite alérgica
Falsarella, Nelson
Rinite
Doenças Respiratórias
Alergia e Imunologia
Rhinitis
Respiratory Tract Diseases
Allergy and Immunology
CIENCIAS DA SAUDE::MEDICINA
title_short Evidência de associação entre grupo sanguíneo O e rinite alérgica
title_full Evidência de associação entre grupo sanguíneo O e rinite alérgica
title_fullStr Evidência de associação entre grupo sanguíneo O e rinite alérgica
title_full_unstemmed Evidência de associação entre grupo sanguíneo O e rinite alérgica
title_sort Evidência de associação entre grupo sanguíneo O e rinite alérgica
author Falsarella, Nelson
author_facet Falsarella, Nelson
author_role author
dc.contributor.advisor1.fl_str_mv Mattos, Luiz Carlos de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1355463443978857
dc.contributor.referee1.fl_str_mv Moreira, Haroldo Wilson
dc.contributor.referee2.fl_str_mv Barboza, Marcelo A. Ingraci
dc.contributor.authorID.fl_str_mv 07468174873
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9344696862473232
dc.contributor.author.fl_str_mv Falsarella, Nelson
contributor_str_mv Mattos, Luiz Carlos de
Moreira, Haroldo Wilson
Barboza, Marcelo A. Ingraci
dc.subject.por.fl_str_mv Rinite
Doenças Respiratórias
Alergia e Imunologia
topic Rinite
Doenças Respiratórias
Alergia e Imunologia
Rhinitis
Respiratory Tract Diseases
Allergy and Immunology
CIENCIAS DA SAUDE::MEDICINA
dc.subject.eng.fl_str_mv Rhinitis
Respiratory Tract Diseases
Allergy and Immunology
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::MEDICINA
description Allergic rhinitis is a disease characterized by inflammatory reactions of the upper airway tract which prevalence increased in the last decades. There are strong evidences that this disease is influenced by environmental and genetic factors. The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis (AR). 168 patients with AR and 168 controls from the same geographical region and paired by gender, and age were enrolled. ABO phenotypes were identified in the red blood cells using the hemagglutination technique. The Fisher exact and the chi-squared tests were employed to compare proportions (P < 0.05). The values of Odds ratio (OR) and confidence interval (CI) at 95% were also calculated. The overall differences in the frequencies of the ABO phenotypes from patients and controls were marginal (χ2: 7.569; DF: 3; P = 0.055), but the O blood group was associated with AR (χ2: 5.764; DF: 1; P: 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences on the frequencies of the O phenotype from patients and controls were statistically different for male (χ2: 8.520; DF: 1; P = 0.003) but not for female (χ2: 0.6375; DF: 1; P = 0.4246). Respectively, the A and O phenotypes were associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; P = 0.049) and susceptibility (OR = 2.789; CI 95%: 1.385-5.616; P = 0.005) to AR only for men. The O blood group phenotype is associated with AR in male but not in female patients.
publishDate 2012
dc.date.issued.fl_str_mv 2012-04-19
dc.date.accessioned.fl_str_mv 2019-02-15T17:23:47Z
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dc.identifier.citation.fl_str_mv Falsarella, Nelson. Evidência de associação entre grupo sanguíneo O e rinite alérgica. 2012. 47 f. Dissertação (Programa de Pós-Graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.
dc.identifier.uri.fl_str_mv http://bdtd.famerp.br/handle/tede/510
dc.identifier.doi.por.fl_str_mv 1085
identifier_str_mv Falsarella, Nelson. Evidência de associação entre grupo sanguíneo O e rinite alérgica. 2012. 47 f. Dissertação (Programa de Pós-Graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.
1085
url http://bdtd.famerp.br/handle/tede/510
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dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Ciências da Saúde
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publisher.none.fl_str_mv Faculdade de Medicina de São José do Rio Preto
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