Evidência de associação entre grupo sanguíneo O e rinite alérgica
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da FAMERP |
Texto Completo: | http://bdtd.famerp.br/handle/tede/510 |
Resumo: | Allergic rhinitis is a disease characterized by inflammatory reactions of the upper airway tract which prevalence increased in the last decades. There are strong evidences that this disease is influenced by environmental and genetic factors. The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis (AR). 168 patients with AR and 168 controls from the same geographical region and paired by gender, and age were enrolled. ABO phenotypes were identified in the red blood cells using the hemagglutination technique. The Fisher exact and the chi-squared tests were employed to compare proportions (P < 0.05). The values of Odds ratio (OR) and confidence interval (CI) at 95% were also calculated. The overall differences in the frequencies of the ABO phenotypes from patients and controls were marginal (χ2: 7.569; DF: 3; P = 0.055), but the O blood group was associated with AR (χ2: 5.764; DF: 1; P: 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences on the frequencies of the O phenotype from patients and controls were statistically different for male (χ2: 8.520; DF: 1; P = 0.003) but not for female (χ2: 0.6375; DF: 1; P = 0.4246). Respectively, the A and O phenotypes were associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; P = 0.049) and susceptibility (OR = 2.789; CI 95%: 1.385-5.616; P = 0.005) to AR only for men. The O blood group phenotype is associated with AR in male but not in female patients. |
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Mattos, Luiz Carlos dehttp://lattes.cnpq.br/1355463443978857Moreira, Haroldo WilsonBarboza, Marcelo A. Ingraci07468174873http://lattes.cnpq.br/9344696862473232Falsarella, Nelson2019-02-15T17:23:47Z2012-04-19Falsarella, Nelson. Evidência de associação entre grupo sanguíneo O e rinite alérgica. 2012. 47 f. Dissertação (Programa de Pós-Graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.1085http://bdtd.famerp.br/handle/tede/510Allergic rhinitis is a disease characterized by inflammatory reactions of the upper airway tract which prevalence increased in the last decades. There are strong evidences that this disease is influenced by environmental and genetic factors. The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis (AR). 168 patients with AR and 168 controls from the same geographical region and paired by gender, and age were enrolled. ABO phenotypes were identified in the red blood cells using the hemagglutination technique. The Fisher exact and the chi-squared tests were employed to compare proportions (P < 0.05). The values of Odds ratio (OR) and confidence interval (CI) at 95% were also calculated. The overall differences in the frequencies of the ABO phenotypes from patients and controls were marginal (χ2: 7.569; DF: 3; P = 0.055), but the O blood group was associated with AR (χ2: 5.764; DF: 1; P: 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences on the frequencies of the O phenotype from patients and controls were statistically different for male (χ2: 8.520; DF: 1; P = 0.003) but not for female (χ2: 0.6375; DF: 1; P = 0.4246). Respectively, the A and O phenotypes were associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; P = 0.049) and susceptibility (OR = 2.789; CI 95%: 1.385-5.616; P = 0.005) to AR only for men. The O blood group phenotype is associated with AR in male but not in female patients.A rinite alérgica é uma doença caracterizada por inflamação das vias aéreas superiores, cuja prevalência cresceu nas últimas décadas. Há fortes evidências de que essa doença seja influenciada por fatores ambientais e genéticos. O objetivo deste estudo foi verificar se os fenótipos ABO estão associados à rinite alérgica (RA). Foram selecionados 168 pacientes com RA e 168 controles sem RA oriundos da mesma região geográfica, pareados por sexo e idade. Os fenótipos ABO foram identificados nos eritrócitos com o uso de método hemaglutinação. Os testes exato de Fisher e qui-quadrado foram empregados para comparar as proporções (p>0,05). Os valores de Odds Ratio e do Intervalo de Confiança (IC) a 95% também foram calculados. As frequências dos fenótipos ABO de pacientes e controles apresentaram diferenças marginais em relação ao nível de significância (χ2: 7.569; GL: 3; p = 0.055), mas o grupo O foi associado à RA (χ2: 5.764; DF: 1; p = 0.016; OR: 1.735; IC 95%: 1.127-2.673). As diferenças nas frequências do grupo O de pacientes e controles foram estatisticamente significantes para o sexo masculino (÷2: 8.520; GL: 1; p = 0.003) mas não para o feminino (χ2: 0.6375; GL: 1; p = 0.4246). Respectivamente, os grupos A e O foram associados à proteção (OR: 0.4385; IC 95%: 0.2043-0.9415; p = 0.049) e suscetibilidade (OR = 2.789; IC 95%: 1.385-5.616; p = 0.005) à RA somente no sexo masculino. O grupo O está associado à RA em pacientes do sexo masculino, mas não naqueles do sexo feminino.Submitted by Suzana Dias (suzana.dias@famerp.br) on 2019-02-15T17:23:46Z No. of bitstreams: 1 NelsonFalsarella_Dissert.pdf: 1152414 bytes, checksum: 026b1c2f541e895b8e087878925b9375 (MD5)Made available in DSpace on 2019-02-15T17:23:47Z (GMT). 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dc.title.por.fl_str_mv |
Evidência de associação entre grupo sanguíneo O e rinite alérgica |
title |
Evidência de associação entre grupo sanguíneo O e rinite alérgica |
spellingShingle |
Evidência de associação entre grupo sanguíneo O e rinite alérgica Falsarella, Nelson Rinite Doenças Respiratórias Alergia e Imunologia Rhinitis Respiratory Tract Diseases Allergy and Immunology CIENCIAS DA SAUDE::MEDICINA |
title_short |
Evidência de associação entre grupo sanguíneo O e rinite alérgica |
title_full |
Evidência de associação entre grupo sanguíneo O e rinite alérgica |
title_fullStr |
Evidência de associação entre grupo sanguíneo O e rinite alérgica |
title_full_unstemmed |
Evidência de associação entre grupo sanguíneo O e rinite alérgica |
title_sort |
Evidência de associação entre grupo sanguíneo O e rinite alérgica |
author |
Falsarella, Nelson |
author_facet |
Falsarella, Nelson |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Mattos, Luiz Carlos de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1355463443978857 |
dc.contributor.referee1.fl_str_mv |
Moreira, Haroldo Wilson |
dc.contributor.referee2.fl_str_mv |
Barboza, Marcelo A. Ingraci |
dc.contributor.authorID.fl_str_mv |
07468174873 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9344696862473232 |
dc.contributor.author.fl_str_mv |
Falsarella, Nelson |
contributor_str_mv |
Mattos, Luiz Carlos de Moreira, Haroldo Wilson Barboza, Marcelo A. Ingraci |
dc.subject.por.fl_str_mv |
Rinite Doenças Respiratórias Alergia e Imunologia |
topic |
Rinite Doenças Respiratórias Alergia e Imunologia Rhinitis Respiratory Tract Diseases Allergy and Immunology CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Rhinitis Respiratory Tract Diseases Allergy and Immunology |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Allergic rhinitis is a disease characterized by inflammatory reactions of the upper airway tract which prevalence increased in the last decades. There are strong evidences that this disease is influenced by environmental and genetic factors. The aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis (AR). 168 patients with AR and 168 controls from the same geographical region and paired by gender, and age were enrolled. ABO phenotypes were identified in the red blood cells using the hemagglutination technique. The Fisher exact and the chi-squared tests were employed to compare proportions (P < 0.05). The values of Odds ratio (OR) and confidence interval (CI) at 95% were also calculated. The overall differences in the frequencies of the ABO phenotypes from patients and controls were marginal (χ2: 7.569; DF: 3; P = 0.055), but the O blood group was associated with AR (χ2: 5.764; DF: 1; P: 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences on the frequencies of the O phenotype from patients and controls were statistically different for male (χ2: 8.520; DF: 1; P = 0.003) but not for female (χ2: 0.6375; DF: 1; P = 0.4246). Respectively, the A and O phenotypes were associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; P = 0.049) and susceptibility (OR = 2.789; CI 95%: 1.385-5.616; P = 0.005) to AR only for men. The O blood group phenotype is associated with AR in male but not in female patients. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-04-19 |
dc.date.accessioned.fl_str_mv |
2019-02-15T17:23:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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dc.identifier.citation.fl_str_mv |
Falsarella, Nelson. Evidência de associação entre grupo sanguíneo O e rinite alérgica. 2012. 47 f. Dissertação (Programa de Pós-Graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto. |
dc.identifier.uri.fl_str_mv |
http://bdtd.famerp.br/handle/tede/510 |
dc.identifier.doi.por.fl_str_mv |
1085 |
identifier_str_mv |
Falsarella, Nelson. Evidência de associação entre grupo sanguíneo O e rinite alérgica. 2012. 47 f. Dissertação (Programa de Pós-Graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto. 1085 |
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http://bdtd.famerp.br/handle/tede/510 |
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por |
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500 500 600 |
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Faculdade de Medicina de São José do Rio Preto |
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