Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da FAMERP |
Texto Completo: | http://bdtd.famerp.br/handle/tede/262 |
Resumo: | Background: Arterial Hypertension (AH) is defined by the conformation of systolic blood pressure (SBP) greater than 140 mmHg and / or diastolic blood pressure (DBP) greater than 90 mmHg. The Joint National Committee VII takes into account the prehypertension stage, characterized by arterial pressure (SBP 120-139 and / or DBP 80-89 mmHg, expression of great interest related to primary prevention. Objective: To assess the effect of treatment with thiazide diuretics or low-dose angiotensin II receptor blocker on central blood pressure and arterial stiffness in pre-hypertensive patients and hypertensive stage 1. Patients and Methods: Patients aged between 30 and 70 years were evaluated from January 2011 to September 2014. The groups were divided into pre-hypertensive (PHA) and stage 1 hypertensive (HA1), in whom the PHA was treated with Chlorthalidone + Amiloride or Placebo, and the HA1 with Chlorthalidone + Amiloride or Losartan; all in low doses. The central systolic blood pressure (PASC) was evaluated by means of Applanation Tonometry during periods of randomization; 6 months and 12 months of treatment. Statistical analysis was performed to compare the PASC behavior in PHA and HA1 patients, ANOVA with Dunets correction was applied in 6-month and 12-month phases. Results: The mean age of the group of pre-hypertensive patients was 52.33 ± 9.01 and in the hypertensive group was 54.0 ± 8.02. The mean systolic and diastolic pressure in the PHA was 125.80 ± 5.93 and 80.71 ± 5.49 and in HA1 was 139.0 ± 7.41 and 89.76 ± 6.59. Statistically significant reduction in central systolic pressure and Augmentation Index 75 was observed, after 12 months of pharmacological treatment in PHA patients. Conclusion: Treatment with active Chlorthalidone + Amiloride or Losartan at low doses reduces the central pressure in adults with hypertension stage 1 from the sixth month of active treatment. In hypertensive individuals showed a decrease in central systolic pressure and Augmentation Index 75, after twelve months of treatment. |
id |
FMRP_7900566b7b234d87db33d084fddf1d81 |
---|---|
oai_identifier_str |
oai:localhost:tede/262 |
network_acronym_str |
FMRP |
network_name_str |
Biblioteca Digital de Teses e Dissertações da FAMERP |
repository_id_str |
4711 |
spelling |
Toledo, Juan Carlos YugarMartin, José Fernando VilelaCesarino, Claudia Bernardi32631431820http://lattes.cnpq.br/1785603379274488Fernandes, Letícia Aparecida Barufi2016-05-30T20:42:52Z2015-10-07Fernandes, Letícia Aparecida Barufi. Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1. 2015. Dissertação ( Programa de Pós-Graduação em Ciências da Saúde ) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.1129http://bdtd.famerp.br/handle/tede/262Background: Arterial Hypertension (AH) is defined by the conformation of systolic blood pressure (SBP) greater than 140 mmHg and / or diastolic blood pressure (DBP) greater than 90 mmHg. The Joint National Committee VII takes into account the prehypertension stage, characterized by arterial pressure (SBP 120-139 and / or DBP 80-89 mmHg, expression of great interest related to primary prevention. Objective: To assess the effect of treatment with thiazide diuretics or low-dose angiotensin II receptor blocker on central blood pressure and arterial stiffness in pre-hypertensive patients and hypertensive stage 1. Patients and Methods: Patients aged between 30 and 70 years were evaluated from January 2011 to September 2014. The groups were divided into pre-hypertensive (PHA) and stage 1 hypertensive (HA1), in whom the PHA was treated with Chlorthalidone + Amiloride or Placebo, and the HA1 with Chlorthalidone + Amiloride or Losartan; all in low doses. The central systolic blood pressure (PASC) was evaluated by means of Applanation Tonometry during periods of randomization; 6 months and 12 months of treatment. Statistical analysis was performed to compare the PASC behavior in PHA and HA1 patients, ANOVA with Dunets correction was applied in 6-month and 12-month phases. Results: The mean age of the group of pre-hypertensive patients was 52.33 ± 9.01 and in the hypertensive group was 54.0 ± 8.02. The mean systolic and diastolic pressure in the PHA was 125.80 ± 5.93 and 80.71 ± 5.49 and in HA1 was 139.0 ± 7.41 and 89.76 ± 6.59. Statistically significant reduction in central systolic pressure and Augmentation Index 75 was observed, after 12 months of pharmacological treatment in PHA patients. Conclusion: Treatment with active Chlorthalidone + Amiloride or Losartan at low doses reduces the central pressure in adults with hypertension stage 1 from the sixth month of active treatment. In hypertensive individuals showed a decrease in central systolic pressure and Augmentation Index 75, after twelve months of treatment.Introdução: A Hipertensão Arterial (HA) é definida por conformação dos valores de pressão arterial sistólica (PAS) superiores a 140 mmHg e/ou pressão arterial diastólica (PAD) superiores a 90 mmHg. O Joint National Committe VII leva em consideração o estágio de pré-hipertensão, caracterizada por valores de pressão arterial (PAS 120 a 139 e/ou PAD 80 a 89 mmHg, expressão de grande interesse em se tratando de prevenção primária. Objetivo: Avaliar o efeito do tratamento com diurético tiazídico ou bloqueador do receptor da angiotensina II em baixa dose sobre a pressão arterial central e rigidez arterial em pacientes pré-hipertenso e hipertenso estágio 1. Casuística e Métodos: Foram avaliados pacientes com idade entre 30 e 70 anos no período de janeiro de 2011 a setembro de 2014. Os grupos foram distribuídos em pré-hipertenso (PHA) e hipertenso estágio1(HA1); nos quais o PHA foi medicado com Clortalidona + Amilorida ou Placebo, e o HA1 com Clortalidona + Amilorida ou Losartana, todos em baixas doses. A pressão arterial sistólica central (PASC) foi avaliada por meio de Tonometria de Aplanação nos períodos de randomização, 6 meses e 12 meses de tratamento. A análise estatística foi realizada para a comparação do comportamento da PASC nos pacientes PHA e HA1; nas fases 06 meses e 12 meses foi aplicado o teste ANOVA com correção de Dunets. Resultados: A média de idade do grupo de pacientes pré-hipertensos foi 52,33 9,01, e no grupo de hipertensos foi de 54,0 8,02. A média da pressão sistólica e diastólica no PHA foi 125,80 5,93 e 80,71 5,49 e no HA1 foi de 139,0 7,41 e 89,76 6,59. Redução estatisticamente significante da pressão sistólica central e do Augmentation Index 75, foi observada após 12 meses de tratamento farmacológico em pacientes PHA. Conclusão: Tratamento ativo com Clortalidona + Amilorida ou Losartana em baixas doses reduz a pressão central em adultos com hipertensão em estágio 1 a partir do sexto mês de tratamento ativo. Em indivíduos pré-hipertensos apresentaram diminuição da pressão sistólica central e do Augmentation Index 75, após doze meses de tratamento.Submitted by Fabíola Silva (fabiola.silva@famerp.br) on 2016-05-30T20:42:52Z No. of bitstreams: 1 leticiaaparecidabarufifernandes_dissert.pdf: 1215208 bytes, checksum: 05800246fe00c47e20737ee2192e21c9 (MD5)Made available in DSpace on 2016-05-30T20:42:52Z (GMT). No. of bitstreams: 1 leticiaaparecidabarufifernandes_dissert.pdf: 1215208 bytes, checksum: 05800246fe00c47e20737ee2192e21c9 (MD5) Previous issue date: 2015-10-07application/pdfporFaculdade de Medicina de São José do Rio PretoPrograma de Pós-Graduação em Ciências da Saúde::1102159680310750095::500FAMERPBrasilFaculdade 1::Departamento 1::306626487509624506::500Health SciencesHypertensionCiências da SaúdeHipertensãoCIENCIAS DA SAUDE::8765449414823306929::600Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da FAMERPinstname:Faculdade de Medicina de São José do Rio Preto (FAMERP)instacron:FAMERPLICENSElicense.txtlicense.txttext/plain; charset=utf-82165bd3efa91386c1718a7f26a329fdcb468MD51ORIGINALleticiaaparecidabarufifernandes_dissert.pdfleticiaaparecidabarufifernandes_dissert.pdfapplication/pdf121520805800246fe00c47e20737ee2192e21c9MD52http://bdtd.famerp.br/bitstream/tede/262/1/license.txthttp://bdtd.famerp.br/bitstream/tede/262/2/leticiaaparecidabarufifernandes_dissert.pdftede/2622019-02-04 11:06:04.584oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.famerp.br/PUBhttps://bdtd.famerp.br/oai/requestsbdc@famerp.br||joao.junior@famerp.bropendoar:47112019-02-04T13:06:04Biblioteca Digital de Teses e Dissertações da FAMERP - Faculdade de Medicina de São José do Rio Preto (FAMERP)false |
dc.title.por.fl_str_mv |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 |
title |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 |
spellingShingle |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 Fernandes, Letícia Aparecida Barufi Health Sciences Hypertension Ciências da Saúde Hipertensão CIENCIAS DA SAUDE::8765449414823306929::600 |
title_short |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 |
title_full |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 |
title_fullStr |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 |
title_full_unstemmed |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 |
title_sort |
Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1 |
author |
Fernandes, Letícia Aparecida Barufi |
author_facet |
Fernandes, Letícia Aparecida Barufi |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Toledo, Juan Carlos Yugar |
dc.contributor.referee1.fl_str_mv |
Martin, José Fernando Vilela |
dc.contributor.referee2.fl_str_mv |
Cesarino, Claudia Bernardi |
dc.contributor.authorID.fl_str_mv |
32631431820 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1785603379274488 |
dc.contributor.author.fl_str_mv |
Fernandes, Letícia Aparecida Barufi |
contributor_str_mv |
Toledo, Juan Carlos Yugar Martin, José Fernando Vilela Cesarino, Claudia Bernardi |
dc.subject.eng.fl_str_mv |
Health Sciences Hypertension |
topic |
Health Sciences Hypertension Ciências da Saúde Hipertensão CIENCIAS DA SAUDE::8765449414823306929::600 |
dc.subject.por.fl_str_mv |
Ciências da Saúde Hipertensão |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::8765449414823306929::600 |
description |
Background: Arterial Hypertension (AH) is defined by the conformation of systolic blood pressure (SBP) greater than 140 mmHg and / or diastolic blood pressure (DBP) greater than 90 mmHg. The Joint National Committee VII takes into account the prehypertension stage, characterized by arterial pressure (SBP 120-139 and / or DBP 80-89 mmHg, expression of great interest related to primary prevention. Objective: To assess the effect of treatment with thiazide diuretics or low-dose angiotensin II receptor blocker on central blood pressure and arterial stiffness in pre-hypertensive patients and hypertensive stage 1. Patients and Methods: Patients aged between 30 and 70 years were evaluated from January 2011 to September 2014. The groups were divided into pre-hypertensive (PHA) and stage 1 hypertensive (HA1), in whom the PHA was treated with Chlorthalidone + Amiloride or Placebo, and the HA1 with Chlorthalidone + Amiloride or Losartan; all in low doses. The central systolic blood pressure (PASC) was evaluated by means of Applanation Tonometry during periods of randomization; 6 months and 12 months of treatment. Statistical analysis was performed to compare the PASC behavior in PHA and HA1 patients, ANOVA with Dunets correction was applied in 6-month and 12-month phases. Results: The mean age of the group of pre-hypertensive patients was 52.33 ± 9.01 and in the hypertensive group was 54.0 ± 8.02. The mean systolic and diastolic pressure in the PHA was 125.80 ± 5.93 and 80.71 ± 5.49 and in HA1 was 139.0 ± 7.41 and 89.76 ± 6.59. Statistically significant reduction in central systolic pressure and Augmentation Index 75 was observed, after 12 months of pharmacological treatment in PHA patients. Conclusion: Treatment with active Chlorthalidone + Amiloride or Losartan at low doses reduces the central pressure in adults with hypertension stage 1 from the sixth month of active treatment. In hypertensive individuals showed a decrease in central systolic pressure and Augmentation Index 75, after twelve months of treatment. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-10-07 |
dc.date.accessioned.fl_str_mv |
2016-05-30T20:42:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Fernandes, Letícia Aparecida Barufi. Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1. 2015. Dissertação ( Programa de Pós-Graduação em Ciências da Saúde ) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto. |
dc.identifier.uri.fl_str_mv |
http://bdtd.famerp.br/handle/tede/262 |
dc.identifier.doi.por.fl_str_mv |
1129 |
identifier_str_mv |
Fernandes, Letícia Aparecida Barufi. Efeito de diurético ou bloqueador do receptor da angiotensina II sobre a pressão arterial central em pacientes com pré-hipertensão e hipertensão arterial estágio 1. 2015. Dissertação ( Programa de Pós-Graduação em Ciências da Saúde ) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto. 1129 |
url |
http://bdtd.famerp.br/handle/tede/262 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências da Saúde::1102159680310750095::500 |
dc.publisher.initials.fl_str_mv |
FAMERP |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade 1::Departamento 1::306626487509624506::500 |
publisher.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da FAMERP instname:Faculdade de Medicina de São José do Rio Preto (FAMERP) instacron:FAMERP |
instname_str |
Faculdade de Medicina de São José do Rio Preto (FAMERP) |
instacron_str |
FAMERP |
institution |
FAMERP |
reponame_str |
Biblioteca Digital de Teses e Dissertações da FAMERP |
collection |
Biblioteca Digital de Teses e Dissertações da FAMERP |
bitstream.url.fl_str_mv |
http://bdtd.famerp.br/bitstream/tede/262/1/license.txt http://bdtd.famerp.br/bitstream/tede/262/2/leticiaaparecidabarufifernandes_dissert.pdf |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 05800246fe00c47e20737ee2192e21c9 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da FAMERP - Faculdade de Medicina de São José do Rio Preto (FAMERP) |
repository.mail.fl_str_mv |
sbdc@famerp.br||joao.junior@famerp.br |
_version_ |
1809113651149275136 |