IVERMECTIN REDUCES SEXUAL DIMORPHISM IN BEHAVIORAL MODELS OF EXPLORATION, ANXIETY AND DEPRESSION IN C57BL/6 MICE

• Autor(a) principal: Bernardi, Maria Martha
• Data de Publicação: 2018
• Outros Autores: Orlando, Bruna Cristina Garcia Silva, Rodrigues, Paula da Silva, Garcia, Pamela Luiz, Kirsten, Thiago Berti
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Atas de Saúde Ambiental
• Texto Completo: https://revistaseletronicas.fmu.br/index.php/ASA/article/view/1813
• topic: open field; elevated plus maze; tail suspension test; avermectins; GABA.; campo aberto; labirinto em cruz elevada; teste de suspensão da cauda; avermectinas; GABA.

Avermectins and milbemycins, often also referred as macrocyclic lactones, are the most used antiparasitic medicines in the world and are widely employed in veterinary medicine, agriculture and human medicine. The objective of this work was to evaluate the sexually dimorphic effects of ivermectin (IVM) in C57BL/6 mice in animal models linked to emotionality. For this, male and female mice were treated with two therapeutic doses of IVM (0.2 or 1.0 mg / kg) or 0.9% saline solution. Twenty-four hours after treatments the mice were observed in open field, elevated plus maze and tail suspension test. The results showed that, in relation to the male mice: 1) ivermectin, in both doses, prevented the sexual dimorphism in the frequency of locomotion and reduced, in females, the frequency of rearing and the time of immobility; 2) in the elevated plus maze, females showed increase in the open arm time and in risk behavior and reduction in the frequency of entries in the closed arm; 3) in the tail suspension test, IVM prevented the expression of sexual dimorphism. It was concluded that in the open field, elevated plus maze and tail suspension ivermectin produces sexually dimorphic effects in C57BL/6 mice. The most prominent effects of ivermectin occurred in females.