The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis

Detalhes bibliográficos
Autor(a) principal: Carvalho,Thiago
Data de Publicação: 2022
Outros Autores: Salgado,Daniel Calduro, Mion,Olavo de Godoy, Mello Junior,João Ferreira de, Voegels,Richard Louis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Archives of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642022000200002
Resumo: Abstract Introduction Idiopathic rhinitis is a nonallergic and noninfectious rhinitis characterized mainly by nasal obstruction and rhinorrhea, resulting from an autonomic imbalance. Botulinum toxin type A (BTX-A) demonstrated its action in reducing rhinorrhea and nasal obstruction when injected into the nasal turbinates or septum. Objective To analyze the effects of intranasal BTX-A injection to control the symptoms of idiopathic rhinitis and its possible adverse effects. Method Patients with idiopathic rhinitis were divided into two groups. Group A had 15 participants (8 female and 6 male), of ages from 47 to 84 years (mean 66.57 years), and these received 60 U of Dysport (Ipsen Ltd, Maidenhead, Berkshire, UK) in each inferior nasal turbinate; group B had 12 participants (1 male and 11 female), of ages from 50 to 76 years (mean 60 years), and they received 1 ml of 0.9% saline. The individuals were reevaluated in the 1st, 2nd, 4th, 8th, and 12th weeks after injection by a questionnaire, accompanied by nasal inspiratory peak flow and acoustic rhinometry. Results Group A showed significant improvement, mainly regarding the symptoms of sneezing/itching and nasal obstruction, over time and when compared to group B. Acoustic rhinometry confirmed the improvement in nasal obstruction. There was no relationship between the nasal peak flow data and the nasal obstruction score. No major adverse effects have been reported. Conclusion The injection of botulinum toxin in the inferior nasal turbinates of patients with idiopathic rhinitis reduces the symptoms of sneezing, itching, nasal obstruction, and runny nose without significant adverse effects, suggesting that it is an option in the treatment of these patients.
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spelling The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitisrhinitisbotulinum toxinnasal obstructionpruritusacoustic rhinometrytherapeuticsAbstract Introduction Idiopathic rhinitis is a nonallergic and noninfectious rhinitis characterized mainly by nasal obstruction and rhinorrhea, resulting from an autonomic imbalance. Botulinum toxin type A (BTX-A) demonstrated its action in reducing rhinorrhea and nasal obstruction when injected into the nasal turbinates or septum. Objective To analyze the effects of intranasal BTX-A injection to control the symptoms of idiopathic rhinitis and its possible adverse effects. Method Patients with idiopathic rhinitis were divided into two groups. Group A had 15 participants (8 female and 6 male), of ages from 47 to 84 years (mean 66.57 years), and these received 60 U of Dysport (Ipsen Ltd, Maidenhead, Berkshire, UK) in each inferior nasal turbinate; group B had 12 participants (1 male and 11 female), of ages from 50 to 76 years (mean 60 years), and they received 1 ml of 0.9% saline. The individuals were reevaluated in the 1st, 2nd, 4th, 8th, and 12th weeks after injection by a questionnaire, accompanied by nasal inspiratory peak flow and acoustic rhinometry. Results Group A showed significant improvement, mainly regarding the symptoms of sneezing/itching and nasal obstruction, over time and when compared to group B. Acoustic rhinometry confirmed the improvement in nasal obstruction. There was no relationship between the nasal peak flow data and the nasal obstruction score. No major adverse effects have been reported. Conclusion The injection of botulinum toxin in the inferior nasal turbinates of patients with idiopathic rhinitis reduces the symptoms of sneezing, itching, nasal obstruction, and runny nose without significant adverse effects, suggesting that it is an option in the treatment of these patients.Fundação Otorrinolaringologia2022-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642022000200002International Archives of Otorhinolaryngology v.26 n.2 2022reponame:International Archives of Otorhinolaryngologyinstname:Fundação Otorrinolaringologia (FORL)instacron:FORL10.1055/s-0041-1730307info:eu-repo/semantics/openAccessCarvalho,ThiagoSalgado,Daniel CalduroMion,Olavo de GodoyMello Junior,João Ferreira deVoegels,Richard Louiseng2022-06-14T00:00:00Zoai:scielo:S1809-48642022000200002Revistahttps://www.scielo.br/j/iao/https://old.scielo.br/oai/scielo-oai.php||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br1809-48641809-4864opendoar:2022-06-14T00:00International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL)false
dc.title.none.fl_str_mv The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
title The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
spellingShingle The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
Carvalho,Thiago
rhinitis
botulinum toxin
nasal obstruction
pruritus
acoustic rhinometry
therapeutics
title_short The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
title_full The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
title_fullStr The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
title_full_unstemmed The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
title_sort The Effect of Turbinate Injection of Botulinum Toxin A on the Symptoms of Idiopathic Rhinitis
author Carvalho,Thiago
author_facet Carvalho,Thiago
Salgado,Daniel Calduro
Mion,Olavo de Godoy
Mello Junior,João Ferreira de
Voegels,Richard Louis
author_role author
author2 Salgado,Daniel Calduro
Mion,Olavo de Godoy
Mello Junior,João Ferreira de
Voegels,Richard Louis
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho,Thiago
Salgado,Daniel Calduro
Mion,Olavo de Godoy
Mello Junior,João Ferreira de
Voegels,Richard Louis
dc.subject.por.fl_str_mv rhinitis
botulinum toxin
nasal obstruction
pruritus
acoustic rhinometry
therapeutics
topic rhinitis
botulinum toxin
nasal obstruction
pruritus
acoustic rhinometry
therapeutics
description Abstract Introduction Idiopathic rhinitis is a nonallergic and noninfectious rhinitis characterized mainly by nasal obstruction and rhinorrhea, resulting from an autonomic imbalance. Botulinum toxin type A (BTX-A) demonstrated its action in reducing rhinorrhea and nasal obstruction when injected into the nasal turbinates or septum. Objective To analyze the effects of intranasal BTX-A injection to control the symptoms of idiopathic rhinitis and its possible adverse effects. Method Patients with idiopathic rhinitis were divided into two groups. Group A had 15 participants (8 female and 6 male), of ages from 47 to 84 years (mean 66.57 years), and these received 60 U of Dysport (Ipsen Ltd, Maidenhead, Berkshire, UK) in each inferior nasal turbinate; group B had 12 participants (1 male and 11 female), of ages from 50 to 76 years (mean 60 years), and they received 1 ml of 0.9% saline. The individuals were reevaluated in the 1st, 2nd, 4th, 8th, and 12th weeks after injection by a questionnaire, accompanied by nasal inspiratory peak flow and acoustic rhinometry. Results Group A showed significant improvement, mainly regarding the symptoms of sneezing/itching and nasal obstruction, over time and when compared to group B. Acoustic rhinometry confirmed the improvement in nasal obstruction. There was no relationship between the nasal peak flow data and the nasal obstruction score. No major adverse effects have been reported. Conclusion The injection of botulinum toxin in the inferior nasal turbinates of patients with idiopathic rhinitis reduces the symptoms of sneezing, itching, nasal obstruction, and runny nose without significant adverse effects, suggesting that it is an option in the treatment of these patients.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1055/s-0041-1730307
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dc.publisher.none.fl_str_mv Fundação Otorrinolaringologia
publisher.none.fl_str_mv Fundação Otorrinolaringologia
dc.source.none.fl_str_mv International Archives of Otorhinolaryngology v.26 n.2 2022
reponame:International Archives of Otorhinolaryngology
instname:Fundação Otorrinolaringologia (FORL)
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instname_str Fundação Otorrinolaringologia (FORL)
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institution FORL
reponame_str International Archives of Otorhinolaryngology
collection International Archives of Otorhinolaryngology
repository.name.fl_str_mv International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL)
repository.mail.fl_str_mv ||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br
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