Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Archives of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642013000200008 |
Resumo: | INTRODUCTION: Radiotherapy (RT) of head and neck neoplasms often damages the salivary glands. AIM: To examine the pattern of morphologic changes resulting from RT of the head and neck region in minipig parotid glands in a clinical and experimental research setting. METHODS: Twelve 18-month-old male Brazilian minipigs weighing 30-40 kg were selected. Eight minipigs were assigned to the experimental group (group 1) and 4 to the control group (group 2). The RT was performed under general anesthesia at Erasto Gaertner Hospital, Curitiba, Brazil, using an á/â ratio of 2.5. The minipigs from group 1 underwent 3 sessions of irradiation with Cobalt 60 of the head and neck, bilaterally, with 3 exposures of 8 Gy each at 7-day intervals for a total dose of 24 Gy. The animals were sacrificed 12 weeks post-RT. RESULTS: The irradiated parotid glands displayed reductions in the size and number of acini as well as loss of secretory granules. The presence of fibrosis and loss of parenchyma relative to non-irradiated glands were observed, with an average reduction in volume of 54%. CONCLUSIONS: Our results demonstrate that this model for parotid gland damage resulting from an RT regimen appears to be useful for preclinical large animal studies of RT-induced damage and testing novel potential treatment options. Although recent advances in radiation therapy, such as intensity-modulated radiation therapy, have reduced the dose and limited the field of radiation, considerable salivary gland injury still occurs and can greatly impact the patient's quality of life after cancer treatment. |
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International Archives of Otorhinolaryngology |
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Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigsHead and Neck NeoplasmsRadiotherapySalivary GlandsXerostomiaSwine, MiniatureINTRODUCTION: Radiotherapy (RT) of head and neck neoplasms often damages the salivary glands. AIM: To examine the pattern of morphologic changes resulting from RT of the head and neck region in minipig parotid glands in a clinical and experimental research setting. METHODS: Twelve 18-month-old male Brazilian minipigs weighing 30-40 kg were selected. Eight minipigs were assigned to the experimental group (group 1) and 4 to the control group (group 2). The RT was performed under general anesthesia at Erasto Gaertner Hospital, Curitiba, Brazil, using an á/â ratio of 2.5. The minipigs from group 1 underwent 3 sessions of irradiation with Cobalt 60 of the head and neck, bilaterally, with 3 exposures of 8 Gy each at 7-day intervals for a total dose of 24 Gy. The animals were sacrificed 12 weeks post-RT. RESULTS: The irradiated parotid glands displayed reductions in the size and number of acini as well as loss of secretory granules. The presence of fibrosis and loss of parenchyma relative to non-irradiated glands were observed, with an average reduction in volume of 54%. CONCLUSIONS: Our results demonstrate that this model for parotid gland damage resulting from an RT regimen appears to be useful for preclinical large animal studies of RT-induced damage and testing novel potential treatment options. Although recent advances in radiation therapy, such as intensity-modulated radiation therapy, have reduced the dose and limited the field of radiation, considerable salivary gland injury still occurs and can greatly impact the patient's quality of life after cancer treatment.Fundação Otorrinolaringologia2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642013000200008International Archives of Otorhinolaryngology v.17 n.2 2013reponame:International Archives of Otorhinolaryngologyinstname:Fundação Otorrinolaringologia (FORL)instacron:FORL10.7162/S1809-97772013000200008info:eu-repo/semantics/openAccessStramandinoli-Zanicotti,Roberta TargaSassi,Laurindo MoacirSchussel,Juliana LucenaTorres,Maria FernandaFunchal,MelissaSmaniotto,Gustavo HenriqueDissenha,José LuisCarvalho,Andre Lopeseng2013-04-03T00:00:00Zoai:scielo:S1809-48642013000200008Revistahttps://www.scielo.br/j/iao/https://old.scielo.br/oai/scielo-oai.php||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br1809-48641809-4864opendoar:2013-04-03T00:00International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL)false |
dc.title.none.fl_str_mv |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs |
title |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs |
spellingShingle |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs Stramandinoli-Zanicotti,Roberta Targa Head and Neck Neoplasms Radiotherapy Salivary Glands Xerostomia Swine, Miniature |
title_short |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs |
title_full |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs |
title_fullStr |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs |
title_full_unstemmed |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs |
title_sort |
Effect of fractionated radiotherapy on the parotid gland: an experimental study in Brazilian minipigs |
author |
Stramandinoli-Zanicotti,Roberta Targa |
author_facet |
Stramandinoli-Zanicotti,Roberta Targa Sassi,Laurindo Moacir Schussel,Juliana Lucena Torres,Maria Fernanda Funchal,Melissa Smaniotto,Gustavo Henrique Dissenha,José Luis Carvalho,Andre Lopes |
author_role |
author |
author2 |
Sassi,Laurindo Moacir Schussel,Juliana Lucena Torres,Maria Fernanda Funchal,Melissa Smaniotto,Gustavo Henrique Dissenha,José Luis Carvalho,Andre Lopes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Stramandinoli-Zanicotti,Roberta Targa Sassi,Laurindo Moacir Schussel,Juliana Lucena Torres,Maria Fernanda Funchal,Melissa Smaniotto,Gustavo Henrique Dissenha,José Luis Carvalho,Andre Lopes |
dc.subject.por.fl_str_mv |
Head and Neck Neoplasms Radiotherapy Salivary Glands Xerostomia Swine, Miniature |
topic |
Head and Neck Neoplasms Radiotherapy Salivary Glands Xerostomia Swine, Miniature |
description |
INTRODUCTION: Radiotherapy (RT) of head and neck neoplasms often damages the salivary glands. AIM: To examine the pattern of morphologic changes resulting from RT of the head and neck region in minipig parotid glands in a clinical and experimental research setting. METHODS: Twelve 18-month-old male Brazilian minipigs weighing 30-40 kg were selected. Eight minipigs were assigned to the experimental group (group 1) and 4 to the control group (group 2). The RT was performed under general anesthesia at Erasto Gaertner Hospital, Curitiba, Brazil, using an á/â ratio of 2.5. The minipigs from group 1 underwent 3 sessions of irradiation with Cobalt 60 of the head and neck, bilaterally, with 3 exposures of 8 Gy each at 7-day intervals for a total dose of 24 Gy. The animals were sacrificed 12 weeks post-RT. RESULTS: The irradiated parotid glands displayed reductions in the size and number of acini as well as loss of secretory granules. The presence of fibrosis and loss of parenchyma relative to non-irradiated glands were observed, with an average reduction in volume of 54%. CONCLUSIONS: Our results demonstrate that this model for parotid gland damage resulting from an RT regimen appears to be useful for preclinical large animal studies of RT-induced damage and testing novel potential treatment options. Although recent advances in radiation therapy, such as intensity-modulated radiation therapy, have reduced the dose and limited the field of radiation, considerable salivary gland injury still occurs and can greatly impact the patient's quality of life after cancer treatment. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642013000200008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642013000200008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.7162/S1809-97772013000200008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Otorrinolaringologia |
publisher.none.fl_str_mv |
Fundação Otorrinolaringologia |
dc.source.none.fl_str_mv |
International Archives of Otorhinolaryngology v.17 n.2 2013 reponame:International Archives of Otorhinolaryngology instname:Fundação Otorrinolaringologia (FORL) instacron:FORL |
instname_str |
Fundação Otorrinolaringologia (FORL) |
instacron_str |
FORL |
institution |
FORL |
reponame_str |
International Archives of Otorhinolaryngology |
collection |
International Archives of Otorhinolaryngology |
repository.name.fl_str_mv |
International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL) |
repository.mail.fl_str_mv |
||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br |
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1754203974442942464 |