Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | International Archives of Otorhinolaryngology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299 |
Resumo: | Abstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis. |
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International Archives of Otorhinolaryngology |
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Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experiencecancer of the larynxsmokealcohol drinkingsurvival analysisAbstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.Fundação Otorrinolaringologia2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299International Archives of Otorhinolaryngology v.23 n.3 2019reponame:International Archives of Otorhinolaryngologyinstname:Fundação Otorrinolaringologia (FORL)instacron:FORL10.1055/s-0039-1687909info:eu-repo/semantics/openAccessInnocentini,Lara Maria Alencar RamosTeixeira,Alisson HenriqueCasemiro,Luciana AssiratiAndrade,Matheus CarrijoFerrari,Tatiane CristinaRicz,Hilton Marcos AlvesMacedo,Leandro Dorigan deeng2019-10-03T00:00:00Zoai:scielo:S1809-48642019000300299Revistahttps://www.scielo.br/j/iao/https://old.scielo.br/oai/scielo-oai.php||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br1809-48641809-4864opendoar:2019-10-03T00:00International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL)false |
dc.title.none.fl_str_mv |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience |
title |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience |
spellingShingle |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience Innocentini,Lara Maria Alencar Ramos cancer of the larynx smoke alcohol drinking survival analysis |
title_short |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience |
title_full |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience |
title_fullStr |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience |
title_full_unstemmed |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience |
title_sort |
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience |
author |
Innocentini,Lara Maria Alencar Ramos |
author_facet |
Innocentini,Lara Maria Alencar Ramos Teixeira,Alisson Henrique Casemiro,Luciana Assirati Andrade,Matheus Carrijo Ferrari,Tatiane Cristina Ricz,Hilton Marcos Alves Macedo,Leandro Dorigan de |
author_role |
author |
author2 |
Teixeira,Alisson Henrique Casemiro,Luciana Assirati Andrade,Matheus Carrijo Ferrari,Tatiane Cristina Ricz,Hilton Marcos Alves Macedo,Leandro Dorigan de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Innocentini,Lara Maria Alencar Ramos Teixeira,Alisson Henrique Casemiro,Luciana Assirati Andrade,Matheus Carrijo Ferrari,Tatiane Cristina Ricz,Hilton Marcos Alves Macedo,Leandro Dorigan de |
dc.subject.por.fl_str_mv |
cancer of the larynx smoke alcohol drinking survival analysis |
topic |
cancer of the larynx smoke alcohol drinking survival analysis |
description |
Abstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1055/s-0039-1687909 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Otorrinolaringologia |
publisher.none.fl_str_mv |
Fundação Otorrinolaringologia |
dc.source.none.fl_str_mv |
International Archives of Otorhinolaryngology v.23 n.3 2019 reponame:International Archives of Otorhinolaryngology instname:Fundação Otorrinolaringologia (FORL) instacron:FORL |
instname_str |
Fundação Otorrinolaringologia (FORL) |
instacron_str |
FORL |
institution |
FORL |
reponame_str |
International Archives of Otorhinolaryngology |
collection |
International Archives of Otorhinolaryngology |
repository.name.fl_str_mv |
International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL) |
repository.mail.fl_str_mv |
||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br |
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1754203976512831488 |