Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience

Detalhes bibliográficos
Autor(a) principal: Innocentini,Lara Maria Alencar Ramos
Data de Publicação: 2019
Outros Autores: Teixeira,Alisson Henrique, Casemiro,Luciana Assirati, Andrade,Matheus Carrijo, Ferrari,Tatiane Cristina, Ricz,Hilton Marcos Alves, Macedo,Leandro Dorigan de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Archives of Otorhinolaryngology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299
Resumo: Abstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.
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spelling Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experiencecancer of the larynxsmokealcohol drinkingsurvival analysisAbstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.Fundação Otorrinolaringologia2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299International Archives of Otorhinolaryngology v.23 n.3 2019reponame:International Archives of Otorhinolaryngologyinstname:Fundação Otorrinolaringologia (FORL)instacron:FORL10.1055/s-0039-1687909info:eu-repo/semantics/openAccessInnocentini,Lara Maria Alencar RamosTeixeira,Alisson HenriqueCasemiro,Luciana AssiratiAndrade,Matheus CarrijoFerrari,Tatiane CristinaRicz,Hilton Marcos AlvesMacedo,Leandro Dorigan deeng2019-10-03T00:00:00Zoai:scielo:S1809-48642019000300299Revistahttps://www.scielo.br/j/iao/https://old.scielo.br/oai/scielo-oai.php||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br1809-48641809-4864opendoar:2019-10-03T00:00International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL)false
dc.title.none.fl_str_mv Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
title Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
spellingShingle Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
Innocentini,Lara Maria Alencar Ramos
cancer of the larynx
smoke
alcohol drinking
survival analysis
title_short Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
title_full Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
title_fullStr Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
title_full_unstemmed Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
title_sort Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
author Innocentini,Lara Maria Alencar Ramos
author_facet Innocentini,Lara Maria Alencar Ramos
Teixeira,Alisson Henrique
Casemiro,Luciana Assirati
Andrade,Matheus Carrijo
Ferrari,Tatiane Cristina
Ricz,Hilton Marcos Alves
Macedo,Leandro Dorigan de
author_role author
author2 Teixeira,Alisson Henrique
Casemiro,Luciana Assirati
Andrade,Matheus Carrijo
Ferrari,Tatiane Cristina
Ricz,Hilton Marcos Alves
Macedo,Leandro Dorigan de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Innocentini,Lara Maria Alencar Ramos
Teixeira,Alisson Henrique
Casemiro,Luciana Assirati
Andrade,Matheus Carrijo
Ferrari,Tatiane Cristina
Ricz,Hilton Marcos Alves
Macedo,Leandro Dorigan de
dc.subject.por.fl_str_mv cancer of the larynx
smoke
alcohol drinking
survival analysis
topic cancer of the larynx
smoke
alcohol drinking
survival analysis
description Abstract Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS (p = 0.02) and OS (p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients (p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 (p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients (p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-48642019000300299
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1055/s-0039-1687909
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Otorrinolaringologia
publisher.none.fl_str_mv Fundação Otorrinolaringologia
dc.source.none.fl_str_mv International Archives of Otorhinolaryngology v.23 n.3 2019
reponame:International Archives of Otorhinolaryngology
instname:Fundação Otorrinolaringologia (FORL)
instacron:FORL
instname_str Fundação Otorrinolaringologia (FORL)
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institution FORL
reponame_str International Archives of Otorhinolaryngology
collection International Archives of Otorhinolaryngology
repository.name.fl_str_mv International Archives of Otorhinolaryngology - Fundação Otorrinolaringologia (FORL)
repository.mail.fl_str_mv ||iaorl@iaorl.org||archives@internationalarchivesent.org||arquivos@forl.org.br
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