Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017 |
Resumo: | This studyevaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity. |
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Brazilian Dental Journal |
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Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized ratsradiotherapyosteoporosisseleniumovariectomyThis studyevaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity.Fundação Odontológica de Ribeirão Preto2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017Brazilian Dental Journal v.23 n.6 2012reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402012000600017info:eu-repo/semantics/openAccessFreitas,Deborah Queiroz deRamos-Perez,Flávia Maria de MoraesNeves,Ellen GabyMarques,Marcelo RochaBóscolo,Frab NorbertoAlmeida,Solange Maria deeng2013-01-18T00:00:00Zoai:scielo:S0103-64402012000600017Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2013-01-18T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats |
title |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats |
spellingShingle |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats Freitas,Deborah Queiroz de radiotherapy osteoporosis selenium ovariectomy |
title_short |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats |
title_full |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats |
title_fullStr |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats |
title_full_unstemmed |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats |
title_sort |
Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats |
author |
Freitas,Deborah Queiroz de |
author_facet |
Freitas,Deborah Queiroz de Ramos-Perez,Flávia Maria de Moraes Neves,Ellen Gaby Marques,Marcelo Rocha Bóscolo,Frab Norberto Almeida,Solange Maria de |
author_role |
author |
author2 |
Ramos-Perez,Flávia Maria de Moraes Neves,Ellen Gaby Marques,Marcelo Rocha Bóscolo,Frab Norberto Almeida,Solange Maria de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Freitas,Deborah Queiroz de Ramos-Perez,Flávia Maria de Moraes Neves,Ellen Gaby Marques,Marcelo Rocha Bóscolo,Frab Norberto Almeida,Solange Maria de |
dc.subject.por.fl_str_mv |
radiotherapy osteoporosis selenium ovariectomy |
topic |
radiotherapy osteoporosis selenium ovariectomy |
description |
This studyevaluated protection by selenium (Se) in the bone repair process in ovariectomized rats after irradiation. For such purpose, 80 ovariectomized female Wistar rats were randomly divided into 4 experimental groups: ovariectomized (Ov), Ov/Se, Ov/irradiated (Irr) and Ov/ Se/Irr. A bone defect was created on the tibia of all animals 40 days after ovariectomy. Two days after surgery, only the Ov/Se and Ov/Se/Irr rats received 0.8 mg Se/kg. Three days after surgery, only the Ov/Irr and Ov/Se/Irr rats received 10 Gy of x-rays on the lower limb region. The animals were euthanized at 7, 14, 21 and 28 days after surgery to assess the repair process, which was evaluated by analysis of trabecular bone number (Masson Trichrome) and birefringence analysis (Picrosirius). It was possible to observe a delay in the bone repair process in the ovariectomized/irradiated group and similarity between the ovariectomized, Ov/Se and Ov/Se/Irr groups. In conclusion, sodium selenite exerted a radioprotective effect in the bone repair of tibia of ovariectomized rats without toxicity. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402012000600017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.23 n.6 2012 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204092558737408 |