Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402016000500502 |
Resumo: | Abstract This study was conducted to evaluate the effects of treatment with strontium ranelate (SR) on the repair of bone defects and molecular components of bones in femurs. Adult female rats (n=27) were subjected to ovariectomy (OVX) or Sham surgery. Thirty days after surgery, a defect was made in the femur and the animals were then divided into three groups: OVX, SHAM and OVX+SR. Euthanasia was performed four weeks after the bone defect surgery. Repair in bone defect was assessed by computed microtomography (μCT) and chemical composition of cortical bone was analyzed by Fourier transform infrared (FTIR) spectroscopy and energy dispersive X-ray spectroscopy (EDS). The trabecular thickness (Tb.Th) of the newly formed bone in the OVX+SR group was significantly higher than that for the OVX group. The collagen maturity in the OVX+SR group was smaller than in the other two groups. In this group, a significant increase in the amount of strontium (Sr) and a decrease in the amount of calcium (Ca) embedded to bone tissue were also observed. Systemic treatment with SR improved microarchitecture of the newly formed bone inside the defect, but decreased cross-linking of mature collagen in cortical bone. |
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Brazilian Dental Journal |
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Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Ratsstrontium ranelatecortical bonemicrotomographyinfrared spectroscopyX-ray energy dispersive spectroscopyAbstract This study was conducted to evaluate the effects of treatment with strontium ranelate (SR) on the repair of bone defects and molecular components of bones in femurs. Adult female rats (n=27) were subjected to ovariectomy (OVX) or Sham surgery. Thirty days after surgery, a defect was made in the femur and the animals were then divided into three groups: OVX, SHAM and OVX+SR. Euthanasia was performed four weeks after the bone defect surgery. Repair in bone defect was assessed by computed microtomography (μCT) and chemical composition of cortical bone was analyzed by Fourier transform infrared (FTIR) spectroscopy and energy dispersive X-ray spectroscopy (EDS). The trabecular thickness (Tb.Th) of the newly formed bone in the OVX+SR group was significantly higher than that for the OVX group. The collagen maturity in the OVX+SR group was smaller than in the other two groups. In this group, a significant increase in the amount of strontium (Sr) and a decrease in the amount of calcium (Ca) embedded to bone tissue were also observed. Systemic treatment with SR improved microarchitecture of the newly formed bone inside the defect, but decreased cross-linking of mature collagen in cortical bone.Fundação Odontológica de Ribeirão Preto2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402016000500502Brazilian Dental Journal v.27 n.5 2016reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201600693info:eu-repo/semantics/openAccessRosa,Jucely Aparecida daSakane,Kumiko KoibuchiSantos,Karina Cecília PanelliCorrêa,Vivian BradaschiaArana-Chavez,Victor EliasOliveira,Jefferson Xavier deeng2017-01-20T00:00:00Zoai:scielo:S0103-64402016000500502Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2017-01-20T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats |
title |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats |
spellingShingle |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats Rosa,Jucely Aparecida da strontium ranelate cortical bone microtomography infrared spectroscopy X-ray energy dispersive spectroscopy |
title_short |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats |
title_full |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats |
title_fullStr |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats |
title_full_unstemmed |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats |
title_sort |
Strontium Ranelate Effect on the Repair of Bone Defects and Molecular Components of the Cortical Bone of Rats |
author |
Rosa,Jucely Aparecida da |
author_facet |
Rosa,Jucely Aparecida da Sakane,Kumiko Koibuchi Santos,Karina Cecília Panelli Corrêa,Vivian Bradaschia Arana-Chavez,Victor Elias Oliveira,Jefferson Xavier de |
author_role |
author |
author2 |
Sakane,Kumiko Koibuchi Santos,Karina Cecília Panelli Corrêa,Vivian Bradaschia Arana-Chavez,Victor Elias Oliveira,Jefferson Xavier de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rosa,Jucely Aparecida da Sakane,Kumiko Koibuchi Santos,Karina Cecília Panelli Corrêa,Vivian Bradaschia Arana-Chavez,Victor Elias Oliveira,Jefferson Xavier de |
dc.subject.por.fl_str_mv |
strontium ranelate cortical bone microtomography infrared spectroscopy X-ray energy dispersive spectroscopy |
topic |
strontium ranelate cortical bone microtomography infrared spectroscopy X-ray energy dispersive spectroscopy |
description |
Abstract This study was conducted to evaluate the effects of treatment with strontium ranelate (SR) on the repair of bone defects and molecular components of bones in femurs. Adult female rats (n=27) were subjected to ovariectomy (OVX) or Sham surgery. Thirty days after surgery, a defect was made in the femur and the animals were then divided into three groups: OVX, SHAM and OVX+SR. Euthanasia was performed four weeks after the bone defect surgery. Repair in bone defect was assessed by computed microtomography (μCT) and chemical composition of cortical bone was analyzed by Fourier transform infrared (FTIR) spectroscopy and energy dispersive X-ray spectroscopy (EDS). The trabecular thickness (Tb.Th) of the newly formed bone in the OVX+SR group was significantly higher than that for the OVX group. The collagen maturity in the OVX+SR group was smaller than in the other two groups. In this group, a significant increase in the amount of strontium (Sr) and a decrease in the amount of calcium (Ca) embedded to bone tissue were also observed. Systemic treatment with SR improved microarchitecture of the newly formed bone inside the defect, but decreased cross-linking of mature collagen in cortical bone. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402016000500502 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402016000500502 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-6440201600693 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.27 n.5 2016 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204094357045248 |