Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats

Detalhes bibliográficos
Autor(a) principal: Oliveira,Rodrigo Cardoso de
Data de Publicação: 2004
Outros Autores: Menezes,Renato, Cestari,Tânia Mary, Taga,Eulázio Mikio, Taga,Rumio, Buzalaf,Marília Afonso Rabelo, Granjeiro,José Mauro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001
Resumo: The treatment of persistent bone defects has encouraged the search for proper techniques or bone substitutes. In Dentistry, a common problem in the treatment of periodontal bone defects is the growth of tissues within the lesion, such as the junctional epithelium, which impair regeneration of these tissues. Guided tissue regeneration (GTR), based on the separation of the tissues by means of membranes or barriers, was developed in an attempt to improve periodontal regeneration. The aim of this study was to histologically evaluate the tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats. The study periods were 1, 3, 7, 15, 30 and 60 days after implantation. Analysis of the histological sections demonstrated a moderate to intense inflammatory response at 1 and 3 days, moderate at 7 and 15 days, and almost absent at 30 and 60 days. Resorption of the membrane began 15 days after implantation, and at 60 days only remnants could be detected in some animals. We concluded that the demineralized bovine cortical bone membrane was well tolerated by the tissues and is completely resorbed after 30-60 days by mononuclear cells and multinucleated giant cells, which disappear upon completion of the process.
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spelling Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of ratsGTRbarrierbiomaterialsabsorbable membraneThe treatment of persistent bone defects has encouraged the search for proper techniques or bone substitutes. In Dentistry, a common problem in the treatment of periodontal bone defects is the growth of tissues within the lesion, such as the junctional epithelium, which impair regeneration of these tissues. Guided tissue regeneration (GTR), based on the separation of the tissues by means of membranes or barriers, was developed in an attempt to improve periodontal regeneration. The aim of this study was to histologically evaluate the tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats. The study periods were 1, 3, 7, 15, 30 and 60 days after implantation. Analysis of the histological sections demonstrated a moderate to intense inflammatory response at 1 and 3 days, moderate at 7 and 15 days, and almost absent at 30 and 60 days. Resorption of the membrane began 15 days after implantation, and at 60 days only remnants could be detected in some animals. We concluded that the demineralized bovine cortical bone membrane was well tolerated by the tissues and is completely resorbed after 30-60 days by mononuclear cells and multinucleated giant cells, which disappear upon completion of the process.Fundação Odontológica de Ribeirão Preto2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001Brazilian Dental Journal v.15 n.1 2004reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402004000100001info:eu-repo/semantics/openAccessOliveira,Rodrigo Cardoso deMenezes,RenatoCestari,Tânia MaryTaga,Eulázio MikioTaga,RumioBuzalaf,Marília Afonso RabeloGranjeiro,José Mauroeng2004-08-16T00:00:00Zoai:scielo:S0103-64402004000100001Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2004-08-16T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
title Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
spellingShingle Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
Oliveira,Rodrigo Cardoso de
GTR
barrier
biomaterials
absorbable membrane
title_short Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
title_full Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
title_fullStr Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
title_full_unstemmed Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
title_sort Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
author Oliveira,Rodrigo Cardoso de
author_facet Oliveira,Rodrigo Cardoso de
Menezes,Renato
Cestari,Tânia Mary
Taga,Eulázio Mikio
Taga,Rumio
Buzalaf,Marília Afonso Rabelo
Granjeiro,José Mauro
author_role author
author2 Menezes,Renato
Cestari,Tânia Mary
Taga,Eulázio Mikio
Taga,Rumio
Buzalaf,Marília Afonso Rabelo
Granjeiro,José Mauro
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Rodrigo Cardoso de
Menezes,Renato
Cestari,Tânia Mary
Taga,Eulázio Mikio
Taga,Rumio
Buzalaf,Marília Afonso Rabelo
Granjeiro,José Mauro
dc.subject.por.fl_str_mv GTR
barrier
biomaterials
absorbable membrane
topic GTR
barrier
biomaterials
absorbable membrane
description The treatment of persistent bone defects has encouraged the search for proper techniques or bone substitutes. In Dentistry, a common problem in the treatment of periodontal bone defects is the growth of tissues within the lesion, such as the junctional epithelium, which impair regeneration of these tissues. Guided tissue regeneration (GTR), based on the separation of the tissues by means of membranes or barriers, was developed in an attempt to improve periodontal regeneration. The aim of this study was to histologically evaluate the tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats. The study periods were 1, 3, 7, 15, 30 and 60 days after implantation. Analysis of the histological sections demonstrated a moderate to intense inflammatory response at 1 and 3 days, moderate at 7 and 15 days, and almost absent at 30 and 60 days. Resorption of the membrane began 15 days after implantation, and at 60 days only remnants could be detected in some animals. We concluded that the demineralized bovine cortical bone membrane was well tolerated by the tissues and is completely resorbed after 30-60 days by mononuclear cells and multinucleated giant cells, which disappear upon completion of the process.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402004000100001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.15 n.1 2004
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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