Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001 |
Resumo: | The treatment of persistent bone defects has encouraged the search for proper techniques or bone substitutes. In Dentistry, a common problem in the treatment of periodontal bone defects is the growth of tissues within the lesion, such as the junctional epithelium, which impair regeneration of these tissues. Guided tissue regeneration (GTR), based on the separation of the tissues by means of membranes or barriers, was developed in an attempt to improve periodontal regeneration. The aim of this study was to histologically evaluate the tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats. The study periods were 1, 3, 7, 15, 30 and 60 days after implantation. Analysis of the histological sections demonstrated a moderate to intense inflammatory response at 1 and 3 days, moderate at 7 and 15 days, and almost absent at 30 and 60 days. Resorption of the membrane began 15 days after implantation, and at 60 days only remnants could be detected in some animals. We concluded that the demineralized bovine cortical bone membrane was well tolerated by the tissues and is completely resorbed after 30-60 days by mononuclear cells and multinucleated giant cells, which disappear upon completion of the process. |
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Brazilian Dental Journal |
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Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of ratsGTRbarrierbiomaterialsabsorbable membraneThe treatment of persistent bone defects has encouraged the search for proper techniques or bone substitutes. In Dentistry, a common problem in the treatment of periodontal bone defects is the growth of tissues within the lesion, such as the junctional epithelium, which impair regeneration of these tissues. Guided tissue regeneration (GTR), based on the separation of the tissues by means of membranes or barriers, was developed in an attempt to improve periodontal regeneration. The aim of this study was to histologically evaluate the tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats. The study periods were 1, 3, 7, 15, 30 and 60 days after implantation. Analysis of the histological sections demonstrated a moderate to intense inflammatory response at 1 and 3 days, moderate at 7 and 15 days, and almost absent at 30 and 60 days. Resorption of the membrane began 15 days after implantation, and at 60 days only remnants could be detected in some animals. We concluded that the demineralized bovine cortical bone membrane was well tolerated by the tissues and is completely resorbed after 30-60 days by mononuclear cells and multinucleated giant cells, which disappear upon completion of the process.Fundação Odontológica de Ribeirão Preto2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001Brazilian Dental Journal v.15 n.1 2004reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402004000100001info:eu-repo/semantics/openAccessOliveira,Rodrigo Cardoso deMenezes,RenatoCestari,Tânia MaryTaga,Eulázio MikioTaga,RumioBuzalaf,Marília Afonso RabeloGranjeiro,José Mauroeng2004-08-16T00:00:00Zoai:scielo:S0103-64402004000100001Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2004-08-16T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats |
title |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats |
spellingShingle |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats Oliveira,Rodrigo Cardoso de GTR barrier biomaterials absorbable membrane |
title_short |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats |
title_full |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats |
title_fullStr |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats |
title_full_unstemmed |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats |
title_sort |
Tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats |
author |
Oliveira,Rodrigo Cardoso de |
author_facet |
Oliveira,Rodrigo Cardoso de Menezes,Renato Cestari,Tânia Mary Taga,Eulázio Mikio Taga,Rumio Buzalaf,Marília Afonso Rabelo Granjeiro,José Mauro |
author_role |
author |
author2 |
Menezes,Renato Cestari,Tânia Mary Taga,Eulázio Mikio Taga,Rumio Buzalaf,Marília Afonso Rabelo Granjeiro,José Mauro |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Rodrigo Cardoso de Menezes,Renato Cestari,Tânia Mary Taga,Eulázio Mikio Taga,Rumio Buzalaf,Marília Afonso Rabelo Granjeiro,José Mauro |
dc.subject.por.fl_str_mv |
GTR barrier biomaterials absorbable membrane |
topic |
GTR barrier biomaterials absorbable membrane |
description |
The treatment of persistent bone defects has encouraged the search for proper techniques or bone substitutes. In Dentistry, a common problem in the treatment of periodontal bone defects is the growth of tissues within the lesion, such as the junctional epithelium, which impair regeneration of these tissues. Guided tissue regeneration (GTR), based on the separation of the tissues by means of membranes or barriers, was developed in an attempt to improve periodontal regeneration. The aim of this study was to histologically evaluate the tissue response to a membrane of demineralized bovine cortical bone implanted in the subcutaneous tissue of rats. The study periods were 1, 3, 7, 15, 30 and 60 days after implantation. Analysis of the histological sections demonstrated a moderate to intense inflammatory response at 1 and 3 days, moderate at 7 and 15 days, and almost absent at 30 and 60 days. Resorption of the membrane began 15 days after implantation, and at 60 days only remnants could be detected in some animals. We concluded that the demineralized bovine cortical bone membrane was well tolerated by the tissues and is completely resorbed after 30-60 days by mononuclear cells and multinucleated giant cells, which disappear upon completion of the process. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402004000100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402004000100001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.15 n.1 2004 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204089719193600 |