Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402018000200140 |
Resumo: | Abstract In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of acute postoperative pain. The randomized and crossover study consisted in evaluating the clinical efficacy of therapy performed by ketoprofen 100 mg (twice daily-b.i.d.) versus ketoprofen 200 mg + omeprazole 20 mg (once daily-q.d.) to pain, swelling and trismus control in the bilateral extraction model of lower third molars in similar positions in two different appointments, in 50 volunteers. Volunteers reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study when they took the combination of ketoprofen 200 mg + omeprazole 20 mg (q.d.). Following administration of both study drugs, no gastrointestinal adverse reactions were reported by volunteers. Furthermore, the evaluations of the drugs in pain control by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg (q.d.). For swelling and trismus control, the treatments presented similar results. In conclusion, when volunteers took ketoprofen 200 mg + omeprazole 20 mg (q.d.), they reported significantly less postoperative pain at various post-surgical periods and consumed less rescue analgesic medication throughout the study compared with ketoprofen 100 mg (b.i.d). |
id |
FUNORP-1_a01582b334c35208718345a13b7c2223 |
---|---|
oai_identifier_str |
oai:scielo:S0103-64402018000200140 |
network_acronym_str |
FUNORP-1 |
network_name_str |
Brazilian Dental Journal |
repository_id_str |
|
spelling |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removalketoprofenomeprazolepain controllower third molar surgeryAbstract In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of acute postoperative pain. The randomized and crossover study consisted in evaluating the clinical efficacy of therapy performed by ketoprofen 100 mg (twice daily-b.i.d.) versus ketoprofen 200 mg + omeprazole 20 mg (once daily-q.d.) to pain, swelling and trismus control in the bilateral extraction model of lower third molars in similar positions in two different appointments, in 50 volunteers. Volunteers reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study when they took the combination of ketoprofen 200 mg + omeprazole 20 mg (q.d.). Following administration of both study drugs, no gastrointestinal adverse reactions were reported by volunteers. Furthermore, the evaluations of the drugs in pain control by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg (q.d.). For swelling and trismus control, the treatments presented similar results. In conclusion, when volunteers took ketoprofen 200 mg + omeprazole 20 mg (q.d.), they reported significantly less postoperative pain at various post-surgical periods and consumed less rescue analgesic medication throughout the study compared with ketoprofen 100 mg (b.i.d).Fundação Odontológica de Ribeirão Preto2018-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402018000200140Brazilian Dental Journal v.29 n.2 2018reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201802254info:eu-repo/semantics/openAccessSimoneti,Luis FernandoWeckwerth,Giovana MariaDionísio,Thiago JoséTorres,Elza AraujoZupelari-Gonçalves,PauloCalvo,Adriana MariaLauris,José RobertoFaria,Flávio CardosoSantos,Carlos Ferreiraeng2018-06-07T00:00:00Zoai:scielo:S0103-64402018000200140Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2018-06-07T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal |
title |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal |
spellingShingle |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal Simoneti,Luis Fernando ketoprofen omeprazole pain control lower third molar surgery |
title_short |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal |
title_full |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal |
title_fullStr |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal |
title_full_unstemmed |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal |
title_sort |
Efficacy of Ketoprofen With or Without Omeprazole for Pain And Inflammation Control After Third Molar Removal |
author |
Simoneti,Luis Fernando |
author_facet |
Simoneti,Luis Fernando Weckwerth,Giovana Maria Dionísio,Thiago José Torres,Elza Araujo Zupelari-Gonçalves,Paulo Calvo,Adriana Maria Lauris,José Roberto Faria,Flávio Cardoso Santos,Carlos Ferreira |
author_role |
author |
author2 |
Weckwerth,Giovana Maria Dionísio,Thiago José Torres,Elza Araujo Zupelari-Gonçalves,Paulo Calvo,Adriana Maria Lauris,José Roberto Faria,Flávio Cardoso Santos,Carlos Ferreira |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Simoneti,Luis Fernando Weckwerth,Giovana Maria Dionísio,Thiago José Torres,Elza Araujo Zupelari-Gonçalves,Paulo Calvo,Adriana Maria Lauris,José Roberto Faria,Flávio Cardoso Santos,Carlos Ferreira |
dc.subject.por.fl_str_mv |
ketoprofen omeprazole pain control lower third molar surgery |
topic |
ketoprofen omeprazole pain control lower third molar surgery |
description |
Abstract In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of acute postoperative pain. The randomized and crossover study consisted in evaluating the clinical efficacy of therapy performed by ketoprofen 100 mg (twice daily-b.i.d.) versus ketoprofen 200 mg + omeprazole 20 mg (once daily-q.d.) to pain, swelling and trismus control in the bilateral extraction model of lower third molars in similar positions in two different appointments, in 50 volunteers. Volunteers reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study when they took the combination of ketoprofen 200 mg + omeprazole 20 mg (q.d.). Following administration of both study drugs, no gastrointestinal adverse reactions were reported by volunteers. Furthermore, the evaluations of the drugs in pain control by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg (q.d.). For swelling and trismus control, the treatments presented similar results. In conclusion, when volunteers took ketoprofen 200 mg + omeprazole 20 mg (q.d.), they reported significantly less postoperative pain at various post-surgical periods and consumed less rescue analgesic medication throughout the study compared with ketoprofen 100 mg (b.i.d). |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402018000200140 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402018000200140 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-6440201802254 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.29 n.2 2018 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204095200100352 |