Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia

Detalhes bibliográficos
Autor(a) principal: Salum,Fernanda Gonçalves
Data de Publicação: 2006
Outros Autores: Martins,Gabriela Botelho, Figueiredo,Maria Antonia Zancanaro de, Cherubini,Karen, Yurgel,Liliane Soares, Torres-Pereira,Cassius
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402006000200015
Resumo: Fanconi anemia (FA) is an autosomal recessive disorder that might cause a variety of congenital and developmental abnormalities. The most important features of FA are progressive bone marrow failure and development of malignancies, particularly acute myeloid leukemia and solid tumors. This paper reports the case of a 12-year-old patient with FA assisted at the Stomatology and Bucomaxillofacial Cancer Prevention Service of São Lucas Hospital, Brazil, who had been submitted to bone marrow transplantation (BMT) at the age of 5 and exhibited oral lesions characteristic of chronic graft versus host disease (GVHD). The patient was treated and followed-up for the oral lesions. Eleven years after the BMT, he developed squamous cell carcinoma of the tongue with an aggressive behavior, which was considered an untreatable condition. The patient died few months later from asphyxia at the age of 16. The reasons for development of these malignant conditions are unknown. However, chromosomal instability typically observed in FA cases, BMT factors and GVHD have been considered. Systematic follow-up of these patients allows early and less invasive therapeutic approaches.
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spelling Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemiaFanconi anemiasquamous cell carcinomabone marrow transplantationFanconi anemia (FA) is an autosomal recessive disorder that might cause a variety of congenital and developmental abnormalities. The most important features of FA are progressive bone marrow failure and development of malignancies, particularly acute myeloid leukemia and solid tumors. This paper reports the case of a 12-year-old patient with FA assisted at the Stomatology and Bucomaxillofacial Cancer Prevention Service of São Lucas Hospital, Brazil, who had been submitted to bone marrow transplantation (BMT) at the age of 5 and exhibited oral lesions characteristic of chronic graft versus host disease (GVHD). The patient was treated and followed-up for the oral lesions. Eleven years after the BMT, he developed squamous cell carcinoma of the tongue with an aggressive behavior, which was considered an untreatable condition. The patient died few months later from asphyxia at the age of 16. The reasons for development of these malignant conditions are unknown. However, chromosomal instability typically observed in FA cases, BMT factors and GVHD have been considered. Systematic follow-up of these patients allows early and less invasive therapeutic approaches.Fundação Odontológica de Ribeirão Preto2006-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402006000200015Brazilian Dental Journal v.17 n.2 2006reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402006000200015info:eu-repo/semantics/openAccessSalum,Fernanda GonçalvesMartins,Gabriela BotelhoFigueiredo,Maria Antonia Zancanaro deCherubini,KarenYurgel,Liliane SoaresTorres-Pereira,Cassiuseng2006-08-14T00:00:00Zoai:scielo:S0103-64402006000200015Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2006-08-14T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
title Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
spellingShingle Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
Salum,Fernanda Gonçalves
Fanconi anemia
squamous cell carcinoma
bone marrow transplantation
title_short Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
title_full Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
title_fullStr Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
title_full_unstemmed Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
title_sort Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia
author Salum,Fernanda Gonçalves
author_facet Salum,Fernanda Gonçalves
Martins,Gabriela Botelho
Figueiredo,Maria Antonia Zancanaro de
Cherubini,Karen
Yurgel,Liliane Soares
Torres-Pereira,Cassius
author_role author
author2 Martins,Gabriela Botelho
Figueiredo,Maria Antonia Zancanaro de
Cherubini,Karen
Yurgel,Liliane Soares
Torres-Pereira,Cassius
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Salum,Fernanda Gonçalves
Martins,Gabriela Botelho
Figueiredo,Maria Antonia Zancanaro de
Cherubini,Karen
Yurgel,Liliane Soares
Torres-Pereira,Cassius
dc.subject.por.fl_str_mv Fanconi anemia
squamous cell carcinoma
bone marrow transplantation
topic Fanconi anemia
squamous cell carcinoma
bone marrow transplantation
description Fanconi anemia (FA) is an autosomal recessive disorder that might cause a variety of congenital and developmental abnormalities. The most important features of FA are progressive bone marrow failure and development of malignancies, particularly acute myeloid leukemia and solid tumors. This paper reports the case of a 12-year-old patient with FA assisted at the Stomatology and Bucomaxillofacial Cancer Prevention Service of São Lucas Hospital, Brazil, who had been submitted to bone marrow transplantation (BMT) at the age of 5 and exhibited oral lesions characteristic of chronic graft versus host disease (GVHD). The patient was treated and followed-up for the oral lesions. Eleven years after the BMT, he developed squamous cell carcinoma of the tongue with an aggressive behavior, which was considered an untreatable condition. The patient died few months later from asphyxia at the age of 16. The reasons for development of these malignant conditions are unknown. However, chromosomal instability typically observed in FA cases, BMT factors and GVHD have been considered. Systematic follow-up of these patients allows early and less invasive therapeutic approaches.
publishDate 2006
dc.date.none.fl_str_mv 2006-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402006000200015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402006000200015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402006000200015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.17 n.2 2006
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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