Wilms tumor 1 protein is not expressed in oral lymphangiomas

Detalhes bibliográficos
Autor(a) principal: Netto,Ana Carolina de Mesquita
Data de Publicação: 2012
Outros Autores: Oliveira,Mariana Batista de, Bernardes,Vanessa Fátima, Gomes,Carolina Cavaliéri, Gomez,Ricardo Santiago
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600014
Resumo: Lymphangiomas are benign hamartomatous lesions of lymphatic vessels. Wilms Tumor 1 (WT1) is a transcription factor that is activated in some human neoplasias. WT1 protein expression is observed in endothelial cells during angiogenesis and is a useful marker to distinguish between vascular proliferations and vascular malformations. The purpose of the present study is to report a case series of oral lymphangiomas together with an immunohistochemical investigation of WT1. Seventeen cases of oral lymphangioma were retrieved and reviewed. Immunohistochemical analysis of WT1 protein was performed and pyogenic granuloma samples were used as positive controls. The male/female ratio was 1.125 and most of the lesions occurred in young subjects. While pyogenic granuloma showed positive staining for WT1, the endothelial cells lining the thin-walled dilated lymphatic vessels of lymphangiomas were negative for this protein. The findings strengthen the idea that oral lymphangioma is a vascular malformation characterized by lymphatic dilatation without significant endothelial proliferation.
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spelling Wilms tumor 1 protein is not expressed in oral lymphangiomasoral lymphangiomaWT1Wilms tumor 1Lymphangiomas are benign hamartomatous lesions of lymphatic vessels. Wilms Tumor 1 (WT1) is a transcription factor that is activated in some human neoplasias. WT1 protein expression is observed in endothelial cells during angiogenesis and is a useful marker to distinguish between vascular proliferations and vascular malformations. The purpose of the present study is to report a case series of oral lymphangiomas together with an immunohistochemical investigation of WT1. Seventeen cases of oral lymphangioma were retrieved and reviewed. Immunohistochemical analysis of WT1 protein was performed and pyogenic granuloma samples were used as positive controls. The male/female ratio was 1.125 and most of the lesions occurred in young subjects. While pyogenic granuloma showed positive staining for WT1, the endothelial cells lining the thin-walled dilated lymphatic vessels of lymphangiomas were negative for this protein. The findings strengthen the idea that oral lymphangioma is a vascular malformation characterized by lymphatic dilatation without significant endothelial proliferation.Fundação Odontológica de Ribeirão Preto2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600014Brazilian Dental Journal v.23 n.6 2012reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402012000600014info:eu-repo/semantics/openAccessNetto,Ana Carolina de MesquitaOliveira,Mariana Batista deBernardes,Vanessa FátimaGomes,Carolina CavaliériGomez,Ricardo Santiagoeng2013-01-18T00:00:00Zoai:scielo:S0103-64402012000600014Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2013-01-18T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Wilms tumor 1 protein is not expressed in oral lymphangiomas
title Wilms tumor 1 protein is not expressed in oral lymphangiomas
spellingShingle Wilms tumor 1 protein is not expressed in oral lymphangiomas
Netto,Ana Carolina de Mesquita
oral lymphangioma
WT1
Wilms tumor 1
title_short Wilms tumor 1 protein is not expressed in oral lymphangiomas
title_full Wilms tumor 1 protein is not expressed in oral lymphangiomas
title_fullStr Wilms tumor 1 protein is not expressed in oral lymphangiomas
title_full_unstemmed Wilms tumor 1 protein is not expressed in oral lymphangiomas
title_sort Wilms tumor 1 protein is not expressed in oral lymphangiomas
author Netto,Ana Carolina de Mesquita
author_facet Netto,Ana Carolina de Mesquita
Oliveira,Mariana Batista de
Bernardes,Vanessa Fátima
Gomes,Carolina Cavaliéri
Gomez,Ricardo Santiago
author_role author
author2 Oliveira,Mariana Batista de
Bernardes,Vanessa Fátima
Gomes,Carolina Cavaliéri
Gomez,Ricardo Santiago
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Netto,Ana Carolina de Mesquita
Oliveira,Mariana Batista de
Bernardes,Vanessa Fátima
Gomes,Carolina Cavaliéri
Gomez,Ricardo Santiago
dc.subject.por.fl_str_mv oral lymphangioma
WT1
Wilms tumor 1
topic oral lymphangioma
WT1
Wilms tumor 1
description Lymphangiomas are benign hamartomatous lesions of lymphatic vessels. Wilms Tumor 1 (WT1) is a transcription factor that is activated in some human neoplasias. WT1 protein expression is observed in endothelial cells during angiogenesis and is a useful marker to distinguish between vascular proliferations and vascular malformations. The purpose of the present study is to report a case series of oral lymphangiomas together with an immunohistochemical investigation of WT1. Seventeen cases of oral lymphangioma were retrieved and reviewed. Immunohistochemical analysis of WT1 protein was performed and pyogenic granuloma samples were used as positive controls. The male/female ratio was 1.125 and most of the lesions occurred in young subjects. While pyogenic granuloma showed positive staining for WT1, the endothelial cells lining the thin-walled dilated lymphatic vessels of lymphangiomas were negative for this protein. The findings strengthen the idea that oral lymphangioma is a vascular malformation characterized by lymphatic dilatation without significant endothelial proliferation.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402012000600014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402012000600014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.23 n.6 2012
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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