Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats

Detalhes bibliográficos
Autor(a) principal: Moraes,Gabriela Fracasso
Data de Publicação: 2022
Outros Autores: Caetano,Rodrigo de Oliveira, Prochnow,Fernanda Harumi Oku, Pupo,Yasmine Mendes, Schussel,Juliana Lucena, Schwartz-Filho,Humberto Osvaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402022000300082
Resumo: Abstract The aim of this study was to evaluate a Demineralized Human Dentine Matrix (DHDM) as viable biomaterial for alveolar ridge preservation in a rat model. Wistar rats were submitted to the extraction of maxillary first molars bilaterally. Sockets were filled with biomaterials and divided into 4 experimental groups (n=5): blood clot, autogenous bone, bovine-derived xenograft (BDX) and DHDM. Animals were sacrificed at 7, 14 e 28 days. Microtomography (uCT) volumetric evaluation and qualitative histological analyses were performed. Results obtained through the uCT showed similar values between the DHDM and the other experimental groups. The histological evaluation demonstrated DHDM with an unspecific inflammatory process and bone neoformation with slow reabsorption of the material. This result indicates that DHDM implanted in rat sockets is biocompatible and reduces the alveolar ridge volume loss after tooth extraction.
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spelling Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in ratsDemineralized human dentin matrixbiomaterialbiocompatibilityalveolar ridge preservationbone substitutesAbstract The aim of this study was to evaluate a Demineralized Human Dentine Matrix (DHDM) as viable biomaterial for alveolar ridge preservation in a rat model. Wistar rats were submitted to the extraction of maxillary first molars bilaterally. Sockets were filled with biomaterials and divided into 4 experimental groups (n=5): blood clot, autogenous bone, bovine-derived xenograft (BDX) and DHDM. Animals were sacrificed at 7, 14 e 28 days. Microtomography (uCT) volumetric evaluation and qualitative histological analyses were performed. Results obtained through the uCT showed similar values between the DHDM and the other experimental groups. The histological evaluation demonstrated DHDM with an unspecific inflammatory process and bone neoformation with slow reabsorption of the material. This result indicates that DHDM implanted in rat sockets is biocompatible and reduces the alveolar ridge volume loss after tooth extraction.Fundação Odontológica de Ribeirão Preto2022-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402022000300082Brazilian Dental Journal v.33 n.3 2022reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440202204648info:eu-repo/semantics/openAccessMoraes,Gabriela FracassoCaetano,Rodrigo de OliveiraProchnow,Fernanda Harumi OkuPupo,Yasmine MendesSchussel,Juliana LucenaSchwartz-Filho,Humberto Osvaldoeng2022-06-20T00:00:00Zoai:scielo:S0103-64402022000300082Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2022-06-20T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
title Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
spellingShingle Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
Moraes,Gabriela Fracasso
Demineralized human dentin matrix
biomaterial
biocompatibility
alveolar ridge preservation
bone substitutes
title_short Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
title_full Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
title_fullStr Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
title_full_unstemmed Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
title_sort Demineralized human dentin matrix for alveolar ridge preservation using a volumetric and histologic analyses in rats
author Moraes,Gabriela Fracasso
author_facet Moraes,Gabriela Fracasso
Caetano,Rodrigo de Oliveira
Prochnow,Fernanda Harumi Oku
Pupo,Yasmine Mendes
Schussel,Juliana Lucena
Schwartz-Filho,Humberto Osvaldo
author_role author
author2 Caetano,Rodrigo de Oliveira
Prochnow,Fernanda Harumi Oku
Pupo,Yasmine Mendes
Schussel,Juliana Lucena
Schwartz-Filho,Humberto Osvaldo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Moraes,Gabriela Fracasso
Caetano,Rodrigo de Oliveira
Prochnow,Fernanda Harumi Oku
Pupo,Yasmine Mendes
Schussel,Juliana Lucena
Schwartz-Filho,Humberto Osvaldo
dc.subject.por.fl_str_mv Demineralized human dentin matrix
biomaterial
biocompatibility
alveolar ridge preservation
bone substitutes
topic Demineralized human dentin matrix
biomaterial
biocompatibility
alveolar ridge preservation
bone substitutes
description Abstract The aim of this study was to evaluate a Demineralized Human Dentine Matrix (DHDM) as viable biomaterial for alveolar ridge preservation in a rat model. Wistar rats were submitted to the extraction of maxillary first molars bilaterally. Sockets were filled with biomaterials and divided into 4 experimental groups (n=5): blood clot, autogenous bone, bovine-derived xenograft (BDX) and DHDM. Animals were sacrificed at 7, 14 e 28 days. Microtomography (uCT) volumetric evaluation and qualitative histological analyses were performed. Results obtained through the uCT showed similar values between the DHDM and the other experimental groups. The histological evaluation demonstrated DHDM with an unspecific inflammatory process and bone neoformation with slow reabsorption of the material. This result indicates that DHDM implanted in rat sockets is biocompatible and reduces the alveolar ridge volume loss after tooth extraction.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402022000300082
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402022000300082
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-6440202204648
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.33 n.3 2022
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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