Influence of local tetracycline on the microbiota of alveolar osteitis in rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200006 |
Resumo: | The aim of the present study was to evaluate the effects of local tetracycline on the occurrence of alveolar osteitis in rats, and on the microbiota associated to this infection. Forty Wistar rats were randomly assigned to 4 groups (n=10): I - the rats had the maxillary right incisor extracted and the alveolar wound did not receive any treatment; II - adrenaline and Ringer-PRAS were introduced into the alveolar wound; III - the alveolar wound was irrigated with sterile saline; and IV - the alveolar wound was irrigated with an aqueous solution of tetracycline. Microbial samples from the alveolar wounds were collected 2 days after surgery and inoculated on blood agar (with and without 8 µg/mL of tetracycline) and other selective media, and were incubated in either aerobiosis or anaerobiosis at 37ºC, for 2 to 14 days. It was verified that tetracycline reduced the occurrence of alveolar osteitis in the rats and caused significant changes in the microbiota of the surgical sites, decreasing the number of anaerobes and increasing the participation of tetracycline-resistant and multi-resistant microorganisms. |
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Influence of local tetracycline on the microbiota of alveolar osteitis in ratstetracyclinealveolar osteitisdry alveolusmicroorganismsantimicrobialsThe aim of the present study was to evaluate the effects of local tetracycline on the occurrence of alveolar osteitis in rats, and on the microbiota associated to this infection. Forty Wistar rats were randomly assigned to 4 groups (n=10): I - the rats had the maxillary right incisor extracted and the alveolar wound did not receive any treatment; II - adrenaline and Ringer-PRAS were introduced into the alveolar wound; III - the alveolar wound was irrigated with sterile saline; and IV - the alveolar wound was irrigated with an aqueous solution of tetracycline. Microbial samples from the alveolar wounds were collected 2 days after surgery and inoculated on blood agar (with and without 8 µg/mL of tetracycline) and other selective media, and were incubated in either aerobiosis or anaerobiosis at 37ºC, for 2 to 14 days. It was verified that tetracycline reduced the occurrence of alveolar osteitis in the rats and caused significant changes in the microbiota of the surgical sites, decreasing the number of anaerobes and increasing the participation of tetracycline-resistant and multi-resistant microorganisms.Fundação Odontológica de Ribeirão Preto2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200006Brazilian Dental Journal v.19 n.2 2008reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402008000200006info:eu-repo/semantics/openAccessBosco,Joseane Maria DiasOliveira,Sérgio Ricardo deBosco,Álvaro FranciscoSchweitzer,Christiane MarieJardim Júnior,Elerson Gaettieng2008-06-11T00:00:00Zoai:scielo:S0103-64402008000200006Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2008-06-11T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats |
title |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats |
spellingShingle |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats Bosco,Joseane Maria Dias tetracycline alveolar osteitis dry alveolus microorganisms antimicrobials |
title_short |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats |
title_full |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats |
title_fullStr |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats |
title_full_unstemmed |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats |
title_sort |
Influence of local tetracycline on the microbiota of alveolar osteitis in rats |
author |
Bosco,Joseane Maria Dias |
author_facet |
Bosco,Joseane Maria Dias Oliveira,Sérgio Ricardo de Bosco,Álvaro Francisco Schweitzer,Christiane Marie Jardim Júnior,Elerson Gaetti |
author_role |
author |
author2 |
Oliveira,Sérgio Ricardo de Bosco,Álvaro Francisco Schweitzer,Christiane Marie Jardim Júnior,Elerson Gaetti |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Bosco,Joseane Maria Dias Oliveira,Sérgio Ricardo de Bosco,Álvaro Francisco Schweitzer,Christiane Marie Jardim Júnior,Elerson Gaetti |
dc.subject.por.fl_str_mv |
tetracycline alveolar osteitis dry alveolus microorganisms antimicrobials |
topic |
tetracycline alveolar osteitis dry alveolus microorganisms antimicrobials |
description |
The aim of the present study was to evaluate the effects of local tetracycline on the occurrence of alveolar osteitis in rats, and on the microbiota associated to this infection. Forty Wistar rats were randomly assigned to 4 groups (n=10): I - the rats had the maxillary right incisor extracted and the alveolar wound did not receive any treatment; II - adrenaline and Ringer-PRAS were introduced into the alveolar wound; III - the alveolar wound was irrigated with sterile saline; and IV - the alveolar wound was irrigated with an aqueous solution of tetracycline. Microbial samples from the alveolar wounds were collected 2 days after surgery and inoculated on blood agar (with and without 8 µg/mL of tetracycline) and other selective media, and were incubated in either aerobiosis or anaerobiosis at 37ºC, for 2 to 14 days. It was verified that tetracycline reduced the occurrence of alveolar osteitis in the rats and caused significant changes in the microbiota of the surgical sites, decreasing the number of anaerobes and increasing the participation of tetracycline-resistant and multi-resistant microorganisms. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402008000200006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.19 n.2 2008 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204090856898560 |