EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET

Detalhes bibliográficos
Autor(a) principal: Hoeller, Alexandre Ademar
Data de Publicação: 2016
Outros Autores: de Carvalho, Cristiane Ribeiro, Walz, Roger, de Lima, Thereza Christina Monteiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Vittalle (Online)
Texto Completo: https://periodicos.furg.br/vittalle/article/view/6164
Resumo: Over the last decades it has been observed a major breakthrough in the development of new drugs in the treatment of emotional disorders. Despite this evolutionary framework, the neurobiological mechanisms involved in anxiety process are poorly understood and new approaches are still required, taking into account the resistance to therapies and therapeutic side-effects. Despite the clear involvement of muscarinic acetylcholine receptors (mAChR) in the modulation of synaptic transmission and its role in controlling experimental epileptogenesis and emotional outcomes, little attention has been paid to this neurotransmitter system and its feasible action in the treatment of pathological processes. In this sense, the present review aims to shed light on this important, but not deeply explored receptor system in the control of experimental epilepsy and anxiety, besides discussing its implementation in translational studies.
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spelling EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGETAnxietyEpilepsyAcetylcholineMuscarinic receptorsOver the last decades it has been observed a major breakthrough in the development of new drugs in the treatment of emotional disorders. Despite this evolutionary framework, the neurobiological mechanisms involved in anxiety process are poorly understood and new approaches are still required, taking into account the resistance to therapies and therapeutic side-effects. Despite the clear involvement of muscarinic acetylcholine receptors (mAChR) in the modulation of synaptic transmission and its role in controlling experimental epileptogenesis and emotional outcomes, little attention has been paid to this neurotransmitter system and its feasible action in the treatment of pathological processes. In this sense, the present review aims to shed light on this important, but not deeply explored receptor system in the control of experimental epilepsy and anxiety, besides discussing its implementation in translational studies.Universidade Federal do Rio Grande2016-12-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://periodicos.furg.br/vittalle/article/view/6164VITTALLE - Revista de Ciências da Saúde; v. 28 (2016); 27-382177-78531413-3563reponame:Vittalle (Online)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGenghttps://periodicos.furg.br/vittalle/article/view/6164/4228Copyright (c) 2016 VITTALLE - Revista de Ciências da Saúdeinfo:eu-repo/semantics/openAccessHoeller, Alexandre Ademarde Carvalho, Cristiane RibeiroWalz, Rogerde Lima, Thereza Christina Monteiro2018-11-09T12:51:10Zoai:periodicos.furg.br:article/6164Revistahttps://periodicos.furg.br/vittallePUBhttps://periodicos.furg.br/vittalle/oaivittalle@furg.br2177-78531413-3563opendoar:2018-11-09T12:51:10Vittalle (Online) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
title EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
spellingShingle EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
Hoeller, Alexandre Ademar
Anxiety
Epilepsy
Acetylcholine
Muscarinic receptors
title_short EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
title_full EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
title_fullStr EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
title_full_unstemmed EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
title_sort EXPERIMENTAL EMOTIONAL DISORDERS IN EPILEPSY AND THE IMPLICATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS: A FORGOTTEN PUTATIVE THERAPEUTIC TARGET
author Hoeller, Alexandre Ademar
author_facet Hoeller, Alexandre Ademar
de Carvalho, Cristiane Ribeiro
Walz, Roger
de Lima, Thereza Christina Monteiro
author_role author
author2 de Carvalho, Cristiane Ribeiro
Walz, Roger
de Lima, Thereza Christina Monteiro
author2_role author
author
author
dc.contributor.author.fl_str_mv Hoeller, Alexandre Ademar
de Carvalho, Cristiane Ribeiro
Walz, Roger
de Lima, Thereza Christina Monteiro
dc.subject.por.fl_str_mv Anxiety
Epilepsy
Acetylcholine
Muscarinic receptors
topic Anxiety
Epilepsy
Acetylcholine
Muscarinic receptors
description Over the last decades it has been observed a major breakthrough in the development of new drugs in the treatment of emotional disorders. Despite this evolutionary framework, the neurobiological mechanisms involved in anxiety process are poorly understood and new approaches are still required, taking into account the resistance to therapies and therapeutic side-effects. Despite the clear involvement of muscarinic acetylcholine receptors (mAChR) in the modulation of synaptic transmission and its role in controlling experimental epileptogenesis and emotional outcomes, little attention has been paid to this neurotransmitter system and its feasible action in the treatment of pathological processes. In this sense, the present review aims to shed light on this important, but not deeply explored receptor system in the control of experimental epilepsy and anxiety, besides discussing its implementation in translational studies.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.furg.br/vittalle/article/view/6164
url https://periodicos.furg.br/vittalle/article/view/6164
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.furg.br/vittalle/article/view/6164/4228
dc.rights.driver.fl_str_mv Copyright (c) 2016 VITTALLE - Revista de Ciências da Saúde
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2016 VITTALLE - Revista de Ciências da Saúde
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande
publisher.none.fl_str_mv Universidade Federal do Rio Grande
dc.source.none.fl_str_mv VITTALLE - Revista de Ciências da Saúde; v. 28 (2016); 27-38
2177-7853
1413-3563
reponame:Vittalle (Online)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Vittalle (Online)
collection Vittalle (Online)
repository.name.fl_str_mv Vittalle (Online) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv vittalle@furg.br
_version_ 1797041719098736640

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