Hemodialysis improves endothelial venous function in end-stage renal disease
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/3183 http://dx.doi.org/10.1590/S0100-879X2008000600008 |
Resumo: | The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 months, immediately before and after a hemodialysis session, and 10 healthy controls matched for age and gender. Endothelial function was assessed by the dorsal hand vein technique using graded local infusion of acetylcholine (endothelium-dependent venodilation, EDV) and sodium nitroprusside (endothelium-independent venodilation). Oxidative stress was evaluated by measuring protein oxidative damage (carbonyls) and antioxidant defense (total radical trapping antioxidant potential - TRAP) in blood samples. All patients were receiving recombinant human erythropoietin for at least 3 months and were not taking nitrates or α-receptor antagonists. EDV was significantly lower in ESRD patients before hemodialysis (65.6 ± 10.5) vs controls (109.6 ± 10.8; P = 0.010) and after hemodialysis (106.6 ± 15.7; P = 0.045). Endotheliumindependent venodilation was similar in all comparisons performed. The hemodialysis session significantly decreased TRAP(402.0 ± 53.5 vs 157.1 ± 28.3 U Trolox/μL plasma; P = 0.001). There was no difference in protein damage comparing ESRD patients before and after hemodialysis. The magnitude of change in the EDV was correlated negatively with the magnitude of change in TRAP (r = -0.70; P = 0.037). These results suggest that a hemodialysis session improves endothelial venous function, in association with an antioxidant effect. |
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Silva, Antônio Marcos Vargas daSignori, Luis UlissesPlentz, Rodrigo Della MéaMoreno Junior, HeitorBarros, ErnestoBelló Klein, AdrianeSchaan, Beatriz D'AgordIrigoyen, Maria Claudia Costa2013-03-22T06:16:19Z2013-03-22T06:16:19Z2008SILVA, Antônio Marcos Vargas da et al. Hemodialysis improves endothelial venous function in end-stage renal disease. Brazilian Journal of Medical and Biological Research, v. 41, n. 6, p. 482-488, 2008. Disponível em: <http://www.scielo.br/pdf/bjmbr/v41n6/7039.pdf>. Acesso em: 20 dez. 2012.0100-879Xhttp://repositorio.furg.br/handle/1/3183http://dx.doi.org/10.1590/S0100-879X2008000600008The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 months, immediately before and after a hemodialysis session, and 10 healthy controls matched for age and gender. Endothelial function was assessed by the dorsal hand vein technique using graded local infusion of acetylcholine (endothelium-dependent venodilation, EDV) and sodium nitroprusside (endothelium-independent venodilation). Oxidative stress was evaluated by measuring protein oxidative damage (carbonyls) and antioxidant defense (total radical trapping antioxidant potential - TRAP) in blood samples. All patients were receiving recombinant human erythropoietin for at least 3 months and were not taking nitrates or α-receptor antagonists. EDV was significantly lower in ESRD patients before hemodialysis (65.6 ± 10.5) vs controls (109.6 ± 10.8; P = 0.010) and after hemodialysis (106.6 ± 15.7; P = 0.045). Endotheliumindependent venodilation was similar in all comparisons performed. The hemodialysis session significantly decreased TRAP(402.0 ± 53.5 vs 157.1 ± 28.3 U Trolox/μL plasma; P = 0.001). There was no difference in protein damage comparing ESRD patients before and after hemodialysis. The magnitude of change in the EDV was correlated negatively with the magnitude of change in TRAP (r = -0.70; P = 0.037). These results suggest that a hemodialysis session improves endothelial venous function, in association with an antioxidant effect.engEnd-stage renal diseaseHemodialysisOxidative stressVascular endotheliumHemodialysis improves endothelial venous function in end-stage renal diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALHemodialysis improves endothelial venous function in end-stage renal disease.pdfHemodialysis improves endothelial venous function in end-stage renal disease.pdfapplication/pdf482713https://repositorio.furg.br/bitstream/1/3183/1/Hemodialysis%20improves%20endothelial%20venous%20function%20in%20end-stage%20renal%20disease.pdf55e6ab9b3fc36610f26dcbbc9f462945MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81724https://repositorio.furg.br/bitstream/1/3183/2/license.txt5b92b9704b4f13242d70e45ddef35a68MD52open access1/31832013-03-22 03:16:19.15open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2013-03-22T06:16:19Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Hemodialysis improves endothelial venous function in end-stage renal disease |
title |
Hemodialysis improves endothelial venous function in end-stage renal disease |
spellingShingle |
Hemodialysis improves endothelial venous function in end-stage renal disease Silva, Antônio Marcos Vargas da End-stage renal disease Hemodialysis Oxidative stress Vascular endothelium |
title_short |
Hemodialysis improves endothelial venous function in end-stage renal disease |
title_full |
Hemodialysis improves endothelial venous function in end-stage renal disease |
title_fullStr |
Hemodialysis improves endothelial venous function in end-stage renal disease |
title_full_unstemmed |
Hemodialysis improves endothelial venous function in end-stage renal disease |
title_sort |
Hemodialysis improves endothelial venous function in end-stage renal disease |
author |
Silva, Antônio Marcos Vargas da |
author_facet |
Silva, Antônio Marcos Vargas da Signori, Luis Ulisses Plentz, Rodrigo Della Méa Moreno Junior, Heitor Barros, Ernesto Belló Klein, Adriane Schaan, Beatriz D'Agord Irigoyen, Maria Claudia Costa |
author_role |
author |
author2 |
Signori, Luis Ulisses Plentz, Rodrigo Della Méa Moreno Junior, Heitor Barros, Ernesto Belló Klein, Adriane Schaan, Beatriz D'Agord Irigoyen, Maria Claudia Costa |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Antônio Marcos Vargas da Signori, Luis Ulisses Plentz, Rodrigo Della Méa Moreno Junior, Heitor Barros, Ernesto Belló Klein, Adriane Schaan, Beatriz D'Agord Irigoyen, Maria Claudia Costa |
dc.subject.por.fl_str_mv |
End-stage renal disease Hemodialysis Oxidative stress Vascular endothelium |
topic |
End-stage renal disease Hemodialysis Oxidative stress Vascular endothelium |
description |
The objective of the present study was to determine the acute effect of hemodialysis on endothelial venous function and oxidative stress. We studied 9 patients with end-stage renal disease (ESRD), 36.8 ± 3.0 years old, arterial pressure 133.8 ± 6.8/80.0 ± 5.0 mmHg, time on dialysis 55.0 ± 16.6 months, immediately before and after a hemodialysis session, and 10 healthy controls matched for age and gender. Endothelial function was assessed by the dorsal hand vein technique using graded local infusion of acetylcholine (endothelium-dependent venodilation, EDV) and sodium nitroprusside (endothelium-independent venodilation). Oxidative stress was evaluated by measuring protein oxidative damage (carbonyls) and antioxidant defense (total radical trapping antioxidant potential - TRAP) in blood samples. All patients were receiving recombinant human erythropoietin for at least 3 months and were not taking nitrates or α-receptor antagonists. EDV was significantly lower in ESRD patients before hemodialysis (65.6 ± 10.5) vs controls (109.6 ± 10.8; P = 0.010) and after hemodialysis (106.6 ± 15.7; P = 0.045). Endotheliumindependent venodilation was similar in all comparisons performed. The hemodialysis session significantly decreased TRAP(402.0 ± 53.5 vs 157.1 ± 28.3 U Trolox/μL plasma; P = 0.001). There was no difference in protein damage comparing ESRD patients before and after hemodialysis. The magnitude of change in the EDV was correlated negatively with the magnitude of change in TRAP (r = -0.70; P = 0.037). These results suggest that a hemodialysis session improves endothelial venous function, in association with an antioxidant effect. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2013-03-22T06:16:19Z |
dc.date.available.fl_str_mv |
2013-03-22T06:16:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Antônio Marcos Vargas da et al. Hemodialysis improves endothelial venous function in end-stage renal disease. Brazilian Journal of Medical and Biological Research, v. 41, n. 6, p. 482-488, 2008. Disponível em: <http://www.scielo.br/pdf/bjmbr/v41n6/7039.pdf>. Acesso em: 20 dez. 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/3183 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2008000600008 |
identifier_str_mv |
SILVA, Antônio Marcos Vargas da et al. Hemodialysis improves endothelial venous function in end-stage renal disease. Brazilian Journal of Medical and Biological Research, v. 41, n. 6, p. 482-488, 2008. Disponível em: <http://www.scielo.br/pdf/bjmbr/v41n6/7039.pdf>. Acesso em: 20 dez. 2012. 0100-879X |
url |
http://repositorio.furg.br/handle/1/3183 http://dx.doi.org/10.1590/S0100-879X2008000600008 |
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eng |
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eng |
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