The transition from memory retrieval to extinction
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/2828 |
Resumo: | Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when infused into the hippocampus or the basolateral amygdala at the moment of the first test session but not later. Some, but not all the molecular systems required for extinction are also activated by retrieval, further endorsing the hypothesis that although retrieval is behaviorally and biochemically necessary for the generation of extinction, this last process constitutes a new learning secondary to the unreinforced expression of the original trace. |
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Cammarota, Martín PabloBarros, Daniela MartiVianna, Mônica Ryff Moreira RocaBevilaqua, Lia Rejane MullerCoitinho, Adriana SimonSzapiro, GermanIzquierdo, Luciana AdrianaMedina, Jorge HoracioIzquierdo, Ivan Antônio2012-11-25T00:40:28Z2012-11-25T00:40:28Z2004CAMMAROTA, Martín Pablo et al. The transition from memory retrieval to extinction. Anais da Academia Brasileira de Ciências, v. 76, n.3, p. 573-582, 2004. Disponível em :<http://www.scielo.br/pdf/aabc/v76n3/a11v76n3.pdf>. Acesso em: 20 nov. 2012.0001-3765http://repositorio.furg.br/handle/1/2828Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when infused into the hippocampus or the basolateral amygdala at the moment of the first test session but not later. Some, but not all the molecular systems required for extinction are also activated by retrieval, further endorsing the hypothesis that although retrieval is behaviorally and biochemically necessary for the generation of extinction, this last process constitutes a new learning secondary to the unreinforced expression of the original trace.engMemoryRetrievalExtinctionReconsolidationInhibitory avoidanceThe transition from memory retrieval to extinctioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALThe transition from memory retrieval to extinction.pdfThe transition from memory retrieval to extinction.pdfapplication/pdf111297https://repositorio.furg.br/bitstream/1/2828/1/The%20transition%20from%20memory%20retrieval%20to%20extinction.pdfa79084955a4ed3ba2f26ce4b594e0809MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81724https://repositorio.furg.br/bitstream/1/2828/2/license.txt5b92b9704b4f13242d70e45ddef35a68MD52open access1/28282019-11-13 19:57:05.761open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-13T22:57:05Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
The transition from memory retrieval to extinction |
title |
The transition from memory retrieval to extinction |
spellingShingle |
The transition from memory retrieval to extinction Cammarota, Martín Pablo Memory Retrieval Extinction Reconsolidation Inhibitory avoidance |
title_short |
The transition from memory retrieval to extinction |
title_full |
The transition from memory retrieval to extinction |
title_fullStr |
The transition from memory retrieval to extinction |
title_full_unstemmed |
The transition from memory retrieval to extinction |
title_sort |
The transition from memory retrieval to extinction |
author |
Cammarota, Martín Pablo |
author_facet |
Cammarota, Martín Pablo Barros, Daniela Marti Vianna, Mônica Ryff Moreira Roca Bevilaqua, Lia Rejane Muller Coitinho, Adriana Simon Szapiro, German Izquierdo, Luciana Adriana Medina, Jorge Horacio Izquierdo, Ivan Antônio |
author_role |
author |
author2 |
Barros, Daniela Marti Vianna, Mônica Ryff Moreira Roca Bevilaqua, Lia Rejane Muller Coitinho, Adriana Simon Szapiro, German Izquierdo, Luciana Adriana Medina, Jorge Horacio Izquierdo, Ivan Antônio |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cammarota, Martín Pablo Barros, Daniela Marti Vianna, Mônica Ryff Moreira Roca Bevilaqua, Lia Rejane Muller Coitinho, Adriana Simon Szapiro, German Izquierdo, Luciana Adriana Medina, Jorge Horacio Izquierdo, Ivan Antônio |
dc.subject.por.fl_str_mv |
Memory Retrieval Extinction Reconsolidation Inhibitory avoidance |
topic |
Memory Retrieval Extinction Reconsolidation Inhibitory avoidance |
description |
Memory is measured by measuring retrieval. Retrieval is often triggered by the conditioned stimulus (CS); however, as known since Pavlov, presentation of the CS alone generates extinction. One-trial avoidance (IA) is a much used conditioned fear paradigm in which the CS is the safe part of a training apparatus, the unconditioned stimulus (US) is a footshock and the conditioned response is to stay in the safe area. In IA, retrieval is measured without the US, as latency to step-down from the safe area (i.e., a platform). Extinction is installed at the moment of the first unreinforced test session, as clearly shown by the fact that many drugs, including PKA, ERK and protein synthesis inhibitors as well as NMDA receptor antagonists, hinder extinction when infused into the hippocampus or the basolateral amygdala at the moment of the first test session but not later. Some, but not all the molecular systems required for extinction are also activated by retrieval, further endorsing the hypothesis that although retrieval is behaviorally and biochemically necessary for the generation of extinction, this last process constitutes a new learning secondary to the unreinforced expression of the original trace. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2012-11-25T00:40:28Z |
dc.date.available.fl_str_mv |
2012-11-25T00:40:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CAMMAROTA, Martín Pablo et al. The transition from memory retrieval to extinction. Anais da Academia Brasileira de Ciências, v. 76, n.3, p. 573-582, 2004. Disponível em :<http://www.scielo.br/pdf/aabc/v76n3/a11v76n3.pdf>. Acesso em: 20 nov. 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/2828 |
dc.identifier.issn.none.fl_str_mv |
0001-3765 |
identifier_str_mv |
CAMMAROTA, Martín Pablo et al. The transition from memory retrieval to extinction. Anais da Academia Brasileira de Ciências, v. 76, n.3, p. 573-582, 2004. Disponível em :<http://www.scielo.br/pdf/aabc/v76n3/a11v76n3.pdf>. Acesso em: 20 nov. 2012. 0001-3765 |
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http://repositorio.furg.br/handle/1/2828 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
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Universidade Federal do Rio Grande (FURG) |
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Repositório Institucional da FURG (RI FURG) |
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