Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/2618 http://dx.doi.org/10.1590/S1413-86702009000500007 |
Resumo: | Piperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillintazobactam batches commercialized in the Brazilian market. Five batches from distinct laboratories were tested in duplicate in the Platelia Aspergillus EIA according to the manufacturer’s instructions. Only one drug showed crossreaction at a cut-off of 0.5. Human serum was spiked with this particular drug aiming to mimic achievable piperacillintazobactam concentrations in the serum. Results were all negative for galactomannan detection, even at high drug concentrations. Results from this pilot study suggest that piperacillin-tazobactam might not be a clinically significant cause of false-positive results in the Platelia Aspergillus EIA test in Brazil. |
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Galactomannan detection from piperacillin-tazobactam brands available in the brazilian marketPiperacillin-tazobactamAspergillosisPlatelia aspergillusGalactomannanPiperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillintazobactam batches commercialized in the Brazilian market. Five batches from distinct laboratories were tested in duplicate in the Platelia Aspergillus EIA according to the manufacturer’s instructions. Only one drug showed crossreaction at a cut-off of 0.5. Human serum was spiked with this particular drug aiming to mimic achievable piperacillintazobactam concentrations in the serum. Results were all negative for galactomannan detection, even at high drug concentrations. Results from this pilot study suggest that piperacillin-tazobactam might not be a clinically significant cause of false-positive results in the Platelia Aspergillus EIA test in Brazil.2012-10-08T12:51:14Z2012-10-08T12:51:14Z2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfXAVIER, Melissa Orzechowski et al. Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market. Brazilian Journal of Infectious Diseases, v. 13, n. 5, p. 353-355, 2009. Disponível em: <http://www.scielo.br/pdf/bjid/v13n5/v13n5a07.pdf>. Acesso em: 29 set. 2012.http://repositorio.furg.br/handle/1/2618http://dx.doi.org/10.1590/S1413-86702009000500007engXavier, Melissa OrzechowskiPasqualotto, Alessandro ComarúAquino, Valério RodriguesSukiennikI, Teresa Cristina TeixeiraSevero, Luiz Carlosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2014-09-22T18:02:55Zoai:repositorio.furg.br:1/2618Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2014-09-22T18:02:55Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.none.fl_str_mv |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market |
title |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market |
spellingShingle |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market Xavier, Melissa Orzechowski Piperacillin-tazobactam Aspergillosis Platelia aspergillus Galactomannan |
title_short |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market |
title_full |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market |
title_fullStr |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market |
title_full_unstemmed |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market |
title_sort |
Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market |
author |
Xavier, Melissa Orzechowski |
author_facet |
Xavier, Melissa Orzechowski Pasqualotto, Alessandro Comarú Aquino, Valério Rodrigues SukiennikI, Teresa Cristina Teixeira Severo, Luiz Carlos |
author_role |
author |
author2 |
Pasqualotto, Alessandro Comarú Aquino, Valério Rodrigues SukiennikI, Teresa Cristina Teixeira Severo, Luiz Carlos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Xavier, Melissa Orzechowski Pasqualotto, Alessandro Comarú Aquino, Valério Rodrigues SukiennikI, Teresa Cristina Teixeira Severo, Luiz Carlos |
dc.subject.por.fl_str_mv |
Piperacillin-tazobactam Aspergillosis Platelia aspergillus Galactomannan |
topic |
Piperacillin-tazobactam Aspergillosis Platelia aspergillus Galactomannan |
description |
Piperacillin-tazobactam is a broad spectrum antimicrobial agent that can cause false-positive results in the commercial Platelia Aspergillus EIA test. So far, no study has been performed in Latin America to evaluate the clinical implication of this finding. Here we studied the potential for galactomannan detection in piperacillintazobactam batches commercialized in the Brazilian market. Five batches from distinct laboratories were tested in duplicate in the Platelia Aspergillus EIA according to the manufacturer’s instructions. Only one drug showed crossreaction at a cut-off of 0.5. Human serum was spiked with this particular drug aiming to mimic achievable piperacillintazobactam concentrations in the serum. Results were all negative for galactomannan detection, even at high drug concentrations. Results from this pilot study suggest that piperacillin-tazobactam might not be a clinically significant cause of false-positive results in the Platelia Aspergillus EIA test in Brazil. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 2012-10-08T12:51:14Z 2012-10-08T12:51:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
XAVIER, Melissa Orzechowski et al. Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market. Brazilian Journal of Infectious Diseases, v. 13, n. 5, p. 353-355, 2009. Disponível em: <http://www.scielo.br/pdf/bjid/v13n5/v13n5a07.pdf>. Acesso em: 29 set. 2012. http://repositorio.furg.br/handle/1/2618 http://dx.doi.org/10.1590/S1413-86702009000500007 |
identifier_str_mv |
XAVIER, Melissa Orzechowski et al. Galactomannan detection from piperacillin-tazobactam brands available in the brazilian market. Brazilian Journal of Infectious Diseases, v. 13, n. 5, p. 353-355, 2009. Disponível em: <http://www.scielo.br/pdf/bjid/v13n5/v13n5a07.pdf>. Acesso em: 29 set. 2012. |
url |
http://repositorio.furg.br/handle/1/2618 http://dx.doi.org/10.1590/S1413-86702009000500007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
instacron_str |
FURG |
institution |
FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
repository.mail.fl_str_mv |
|
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1807384361818914816 |