Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population

Detalhes bibliográficos
Autor(a) principal: Vieira, Valdimara Corrêa
Data de Publicação: 2011
Outros Autores: Barral, Maria Fernanda Martínez, Mendoza-Sassi, Raúl Andrés, Silveira, Jussara Maria, Soares, Marcelo Alves, Martinez, Ana Maria Barral de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/2501
http://dx.doi.org/10.1590/S0074-02762011000400005
Resumo: Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency of polymorphisms CCR5-Δ32, CCR2-64I, CCR5-59029A and SDF1-3’A and their role in the course of HIV infection in a southern Brazilian population. Clinical data were obtained from 249 patients for an average period of 6.4 years and genotypes were determined by standard polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism. Survival analyses were conducted for three outcomes: CD4+ T-cell counts below 200 cells/ μl, acquired immune deficiency syndrome (AIDS) or death. The frequency of the polymorphisms CCR5-Δ32, CCR2- 64I, CCR5-59029A and SDF1-3’A were 0.024, 0.113, 0.487 and 0.207, respectively. CCR5-Δ32 was associated with a reduction in the risk for CD4+ T-cell depletion and with an increased risk for death after AIDS diagnosis. CCR2-64I was associated with a reduction in the risk for developing AIDS. SDF1-3’A was also associated with decreased risk for AIDS, but its effect was only evident when CCR2-64I was present as well. These results highlight the possibility of using these markers as indicators for the prognosis of disease progression and provide evidence for the importance of analysing the effects of gene polymorphisms in a combined fashion.
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spelling Vieira, Valdimara CorrêaBarral, Maria Fernanda MartínezMendoza-Sassi, Raúl AndrésSilveira, Jussara MariaSoares, Marcelo AlvesMartinez, Ana Maria Barral de2012-09-13T16:48:10Z2012-09-13T16:48:10Z2011VIEIRA, Valdimara Corrêa et al. Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population. Memórias do Instituto Oswaldo Cruz, v. 106, n. 4, p. 408-414, 2011. Disponível em:<http://www.scielo.br/pdf/mioc/v106n4/05.pdf>. Acesso em: 7 set. 2012.0074-0276http://repositorio.furg.br/handle/1/2501http://dx.doi.org/10.1590/S0074-02762011000400005Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency of polymorphisms CCR5-Δ32, CCR2-64I, CCR5-59029A and SDF1-3’A and their role in the course of HIV infection in a southern Brazilian population. Clinical data were obtained from 249 patients for an average period of 6.4 years and genotypes were determined by standard polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism. Survival analyses were conducted for three outcomes: CD4+ T-cell counts below 200 cells/ μl, acquired immune deficiency syndrome (AIDS) or death. The frequency of the polymorphisms CCR5-Δ32, CCR2- 64I, CCR5-59029A and SDF1-3’A were 0.024, 0.113, 0.487 and 0.207, respectively. CCR5-Δ32 was associated with a reduction in the risk for CD4+ T-cell depletion and with an increased risk for death after AIDS diagnosis. CCR2-64I was associated with a reduction in the risk for developing AIDS. SDF1-3’A was also associated with decreased risk for AIDS, but its effect was only evident when CCR2-64I was present as well. These results highlight the possibility of using these markers as indicators for the prognosis of disease progression and provide evidence for the importance of analysing the effects of gene polymorphisms in a combined fashion.engCCR5-Δ32CCR2-64ICCR5-59029ASDF1-3’AHIVDisease progressionEffect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALThe effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population.pdfThe effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population.pdfapplication/pdf574794https://repositorio.furg.br/bitstream/1/2501/1/The%20effect%20of%20combined%20polymorphims%20in%20chemokines%20and%20chemokine%20receptors%20on%20the%20clinical%20course%20of%20HIV-1%20infection%20in%20a%20Brazilian%20population.pdfa6048d8b622d0c99b741309d7d760eb5MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81678https://repositorio.furg.br/bitstream/1/2501/2/license.txtd3be63d3b3eee02729709361dac69efeMD52open access1/25012019-11-22 10:09:43.202open accessoai:repositorio.furg.br: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ório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-22T13:09:43Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.pt_BR.fl_str_mv Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
title Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
spellingShingle Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
Vieira, Valdimara Corrêa
CCR5-Δ32
CCR2-64I
CCR5-59029A
SDF1-3’A
HIV
Disease progression
title_short Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
title_full Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
title_fullStr Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
title_full_unstemmed Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
title_sort Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
author Vieira, Valdimara Corrêa
author_facet Vieira, Valdimara Corrêa
Barral, Maria Fernanda Martínez
Mendoza-Sassi, Raúl Andrés
Silveira, Jussara Maria
Soares, Marcelo Alves
Martinez, Ana Maria Barral de
author_role author
author2 Barral, Maria Fernanda Martínez
Mendoza-Sassi, Raúl Andrés
Silveira, Jussara Maria
Soares, Marcelo Alves
Martinez, Ana Maria Barral de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira, Valdimara Corrêa
Barral, Maria Fernanda Martínez
Mendoza-Sassi, Raúl Andrés
Silveira, Jussara Maria
Soares, Marcelo Alves
Martinez, Ana Maria Barral de
dc.subject.por.fl_str_mv CCR5-Δ32
CCR2-64I
CCR5-59029A
SDF1-3’A
HIV
Disease progression
topic CCR5-Δ32
CCR2-64I
CCR5-59029A
SDF1-3’A
HIV
Disease progression
description Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency of polymorphisms CCR5-Δ32, CCR2-64I, CCR5-59029A and SDF1-3’A and their role in the course of HIV infection in a southern Brazilian population. Clinical data were obtained from 249 patients for an average period of 6.4 years and genotypes were determined by standard polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism. Survival analyses were conducted for three outcomes: CD4+ T-cell counts below 200 cells/ μl, acquired immune deficiency syndrome (AIDS) or death. The frequency of the polymorphisms CCR5-Δ32, CCR2- 64I, CCR5-59029A and SDF1-3’A were 0.024, 0.113, 0.487 and 0.207, respectively. CCR5-Δ32 was associated with a reduction in the risk for CD4+ T-cell depletion and with an increased risk for death after AIDS diagnosis. CCR2-64I was associated with a reduction in the risk for developing AIDS. SDF1-3’A was also associated with decreased risk for AIDS, but its effect was only evident when CCR2-64I was present as well. These results highlight the possibility of using these markers as indicators for the prognosis of disease progression and provide evidence for the importance of analysing the effects of gene polymorphisms in a combined fashion.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-09-13T16:48:10Z
dc.date.available.fl_str_mv 2012-09-13T16:48:10Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VIEIRA, Valdimara Corrêa et al. Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population. Memórias do Instituto Oswaldo Cruz, v. 106, n. 4, p. 408-414, 2011. Disponível em:<http://www.scielo.br/pdf/mioc/v106n4/05.pdf>. Acesso em: 7 set. 2012.
dc.identifier.uri.fl_str_mv http://repositorio.furg.br/handle/1/2501
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0074-02762011000400005
identifier_str_mv VIEIRA, Valdimara Corrêa et al. Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population. Memórias do Instituto Oswaldo Cruz, v. 106, n. 4, p. 408-414, 2011. Disponível em:<http://www.scielo.br/pdf/mioc/v106n4/05.pdf>. Acesso em: 7 set. 2012.
0074-0276
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