Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/2501 http://dx.doi.org/10.1590/S0074-02762011000400005 |
Resumo: | Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency of polymorphisms CCR5-Δ32, CCR2-64I, CCR5-59029A and SDF1-3’A and their role in the course of HIV infection in a southern Brazilian population. Clinical data were obtained from 249 patients for an average period of 6.4 years and genotypes were determined by standard polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism. Survival analyses were conducted for three outcomes: CD4+ T-cell counts below 200 cells/ μl, acquired immune deficiency syndrome (AIDS) or death. The frequency of the polymorphisms CCR5-Δ32, CCR2- 64I, CCR5-59029A and SDF1-3’A were 0.024, 0.113, 0.487 and 0.207, respectively. CCR5-Δ32 was associated with a reduction in the risk for CD4+ T-cell depletion and with an increased risk for death after AIDS diagnosis. CCR2-64I was associated with a reduction in the risk for developing AIDS. SDF1-3’A was also associated with decreased risk for AIDS, but its effect was only evident when CCR2-64I was present as well. These results highlight the possibility of using these markers as indicators for the prognosis of disease progression and provide evidence for the importance of analysing the effects of gene polymorphisms in a combined fashion. |
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Vieira, Valdimara CorrêaBarral, Maria Fernanda MartínezMendoza-Sassi, Raúl AndrésSilveira, Jussara MariaSoares, Marcelo AlvesMartinez, Ana Maria Barral de2012-09-13T16:48:10Z2012-09-13T16:48:10Z2011VIEIRA, Valdimara Corrêa et al. Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population. Memórias do Instituto Oswaldo Cruz, v. 106, n. 4, p. 408-414, 2011. Disponível em:<http://www.scielo.br/pdf/mioc/v106n4/05.pdf>. Acesso em: 7 set. 2012.0074-0276http://repositorio.furg.br/handle/1/2501http://dx.doi.org/10.1590/S0074-02762011000400005Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency of polymorphisms CCR5-Δ32, CCR2-64I, CCR5-59029A and SDF1-3’A and their role in the course of HIV infection in a southern Brazilian population. Clinical data were obtained from 249 patients for an average period of 6.4 years and genotypes were determined by standard polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism. Survival analyses were conducted for three outcomes: CD4+ T-cell counts below 200 cells/ μl, acquired immune deficiency syndrome (AIDS) or death. The frequency of the polymorphisms CCR5-Δ32, CCR2- 64I, CCR5-59029A and SDF1-3’A were 0.024, 0.113, 0.487 and 0.207, respectively. CCR5-Δ32 was associated with a reduction in the risk for CD4+ T-cell depletion and with an increased risk for death after AIDS diagnosis. CCR2-64I was associated with a reduction in the risk for developing AIDS. SDF1-3’A was also associated with decreased risk for AIDS, but its effect was only evident when CCR2-64I was present as well. These results highlight the possibility of using these markers as indicators for the prognosis of disease progression and provide evidence for the importance of analysing the effects of gene polymorphisms in a combined fashion.engCCR5-Δ32CCR2-64ICCR5-59029ASDF1-3’AHIVDisease progressionEffect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALThe effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population.pdfThe effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population.pdfapplication/pdf574794https://repositorio.furg.br/bitstream/1/2501/1/The%20effect%20of%20combined%20polymorphims%20in%20chemokines%20and%20chemokine%20receptors%20on%20the%20clinical%20course%20of%20HIV-1%20infection%20in%20a%20Brazilian%20population.pdfa6048d8b622d0c99b741309d7d760eb5MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81678https://repositorio.furg.br/bitstream/1/2501/2/license.txtd3be63d3b3eee02729709361dac69efeMD52open access1/25012019-11-22 10:09:43.202open accessoai:repositorio.furg.br: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ório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-11-22T13:09:43Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population |
title |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population |
spellingShingle |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population Vieira, Valdimara Corrêa CCR5-Δ32 CCR2-64I CCR5-59029A SDF1-3’A HIV Disease progression |
title_short |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population |
title_full |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population |
title_fullStr |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population |
title_full_unstemmed |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population |
title_sort |
Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population |
author |
Vieira, Valdimara Corrêa |
author_facet |
Vieira, Valdimara Corrêa Barral, Maria Fernanda Martínez Mendoza-Sassi, Raúl Andrés Silveira, Jussara Maria Soares, Marcelo Alves Martinez, Ana Maria Barral de |
author_role |
author |
author2 |
Barral, Maria Fernanda Martínez Mendoza-Sassi, Raúl Andrés Silveira, Jussara Maria Soares, Marcelo Alves Martinez, Ana Maria Barral de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Vieira, Valdimara Corrêa Barral, Maria Fernanda Martínez Mendoza-Sassi, Raúl Andrés Silveira, Jussara Maria Soares, Marcelo Alves Martinez, Ana Maria Barral de |
dc.subject.por.fl_str_mv |
CCR5-Δ32 CCR2-64I CCR5-59029A SDF1-3’A HIV Disease progression |
topic |
CCR5-Δ32 CCR2-64I CCR5-59029A SDF1-3’A HIV Disease progression |
description |
Polymorphisms in genes that encode chemokines or their receptors can modulate susceptibility to human immunodeficiency virus (HIV) infection and disease progression. The objective of this study was to assess the frequency of polymorphisms CCR5-Δ32, CCR2-64I, CCR5-59029A and SDF1-3’A and their role in the course of HIV infection in a southern Brazilian population. Clinical data were obtained from 249 patients for an average period of 6.4 years and genotypes were determined by standard polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism. Survival analyses were conducted for three outcomes: CD4+ T-cell counts below 200 cells/ μl, acquired immune deficiency syndrome (AIDS) or death. The frequency of the polymorphisms CCR5-Δ32, CCR2- 64I, CCR5-59029A and SDF1-3’A were 0.024, 0.113, 0.487 and 0.207, respectively. CCR5-Δ32 was associated with a reduction in the risk for CD4+ T-cell depletion and with an increased risk for death after AIDS diagnosis. CCR2-64I was associated with a reduction in the risk for developing AIDS. SDF1-3’A was also associated with decreased risk for AIDS, but its effect was only evident when CCR2-64I was present as well. These results highlight the possibility of using these markers as indicators for the prognosis of disease progression and provide evidence for the importance of analysing the effects of gene polymorphisms in a combined fashion. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2012-09-13T16:48:10Z |
dc.date.available.fl_str_mv |
2012-09-13T16:48:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VIEIRA, Valdimara Corrêa et al. Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population. Memórias do Instituto Oswaldo Cruz, v. 106, n. 4, p. 408-414, 2011. Disponível em:<http://www.scielo.br/pdf/mioc/v106n4/05.pdf>. Acesso em: 7 set. 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/2501 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1590/S0074-02762011000400005 |
identifier_str_mv |
VIEIRA, Valdimara Corrêa et al. Effect of combined polymorphims in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a brazilian population. Memórias do Instituto Oswaldo Cruz, v. 106, n. 4, p. 408-414, 2011. Disponível em:<http://www.scielo.br/pdf/mioc/v106n4/05.pdf>. Acesso em: 7 set. 2012. 0074-0276 |
url |
http://repositorio.furg.br/handle/1/2501 http://dx.doi.org/10.1590/S0074-02762011000400005 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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