Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis

Detalhes bibliográficos
Autor(a) principal: Meinerz, Ana Raquel Mano
Data de Publicação: 2008
Outros Autores: Xavier, Melissa Orzechowski, Cleff, Marlete Brum, Madrid, Isabel Martins, Nobre, Márcia de Oliveira, Meireles, Mario Carlos Araujo, Mello, João Roberto Braga de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FURG (RI FURG)
Texto Completo: http://repositorio.furg.br/handle/1/2639
http://dx.doi.org/10.1590/S1517-83822008000400025
Resumo: Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x103 S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and positive organ cultures. There was statistical difference between the groups treated with the antifungals in relation to the control groups (p<0,05) concerning the clinical alterations, anatomic-pathological findings and in the positive organ cultures of the agent, being that the treated animals resulted in the absence and/or reduction of all the evaluated parameters. As for the treatments, terbinafine showed similar or higher activity that itraconazole in the evaluation of the testicle alteration (p=0,0004), as well as in the positive organ cultures of microorganism from the organ (p=0,0142). With these results it is possible to conclude that the antifungals studied are effective in the treatment of experimental systemic sporotrichosis.
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spelling Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosisEficiência de terbinafina e itraconazol em um modelo experimental de esporotricose sistêmicaItraconazoleTerbinafineSporotrichosisAntifungalItraconazolEsporotricoseAntifúngicoItraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x103 S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and positive organ cultures. There was statistical difference between the groups treated with the antifungals in relation to the control groups (p<0,05) concerning the clinical alterations, anatomic-pathological findings and in the positive organ cultures of the agent, being that the treated animals resulted in the absence and/or reduction of all the evaluated parameters. As for the treatments, terbinafine showed similar or higher activity that itraconazole in the evaluation of the testicle alteration (p=0,0004), as well as in the positive organ cultures of microorganism from the organ (p=0,0142). With these results it is possible to conclude that the antifungals studied are effective in the treatment of experimental systemic sporotrichosis.Itraconazol é atualmente considerado a droga de escolha para o tratamento das diferentes formas clínicas da esporotricose. Por outro lado a terbinafina devido a sua excelente atividade in vitro está sendo avaliada quanto ao seu potencial terapêutico frente a diversas infecções fúngicas. O objetivo deste estudo foi determinar a eficácia in vivo da terbinafina e itraconazol em um modelo de esporotricose experimental sistêmica. 120 ratos Wistar receberam uma injeção de 2x103 células de S. schenckii pela veia lateral da cauda. Após 3 dias os animais foram tratados com terbinafina (250mg/kg) e itraconazol (100mg/kg) e os seus respectivos diluentes. No modelo experimental estudado, a terbinafina e itraconazol se mostraram efetivos reduzindo o número de sintomas clínicos e retroisolamento positivo para o agente. Houve diferenças estatísticas entre os grupos tratados com os antifúngicos em relação aos grupos controle (p<0,05)nas alterações clínicas, achados anatomopatológicos e no retroisolamento do agente, sendo que os animais tratados resultaram na ausência e/ou diminuição de todos os parâmetros avaliados. Quanto aos tratamentos a terbinafina se mostrou com atividade similar ou superior ao itraconazol quando avaliado as alterações anatomopatológicos do testículo (p=0,0004), assim como no retoisolamento do órgão (p=0,0142). Com estes resultados permite-se concluir que os antifúngicos estudados são efetivos no tratamento da esporotricose sistêmica experimental.2012-10-18T19:04:17Z2012-10-18T19:04:17Z2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMEINERZ, Ana Raquel Mano et al. Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis. Brazilian Journal of Microbiology, v. 39, n. 4, p. 734-737, 2008. Disponível em: <http://www.scielo.br/pdf/bjm/v39n4/arq25.pdf>. Acesso em: 16 out. 2012http://repositorio.furg.br/handle/1/2639http://dx.doi.org/10.1590/S1517-83822008000400025engMeinerz, Ana Raquel ManoXavier, Melissa OrzechowskiCleff, Marlete BrumMadrid, Isabel MartinsNobre, Márcia de OliveiraMeireles, Mario Carlos AraujoMello, João Roberto Braga deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2012-10-18T19:04:17Zoai:repositorio.furg.br:1/2639Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2012-10-18T19:04:17Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
Eficiência de terbinafina e itraconazol em um modelo experimental de esporotricose sistêmica
title Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
spellingShingle Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
Meinerz, Ana Raquel Mano
Itraconazole
Terbinafine
Sporotrichosis
Antifungal
Itraconazol
Esporotricose
Antifúngico
title_short Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
title_full Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
title_fullStr Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
title_full_unstemmed Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
title_sort Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis
author Meinerz, Ana Raquel Mano
author_facet Meinerz, Ana Raquel Mano
Xavier, Melissa Orzechowski
Cleff, Marlete Brum
Madrid, Isabel Martins
Nobre, Márcia de Oliveira
Meireles, Mario Carlos Araujo
Mello, João Roberto Braga de
author_role author
author2 Xavier, Melissa Orzechowski
Cleff, Marlete Brum
Madrid, Isabel Martins
Nobre, Márcia de Oliveira
Meireles, Mario Carlos Araujo
Mello, João Roberto Braga de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Meinerz, Ana Raquel Mano
Xavier, Melissa Orzechowski
Cleff, Marlete Brum
Madrid, Isabel Martins
Nobre, Márcia de Oliveira
Meireles, Mario Carlos Araujo
Mello, João Roberto Braga de
dc.subject.por.fl_str_mv Itraconazole
Terbinafine
Sporotrichosis
Antifungal
Itraconazol
Esporotricose
Antifúngico
topic Itraconazole
Terbinafine
Sporotrichosis
Antifungal
Itraconazol
Esporotricose
Antifúngico
description Itraconazole is currently considered the drug of choice to treat the diverse clinical presentation of sporotrichosis. On the other hand terbinafine by virtue of its excellent in vitro activity is under comparative evaluation for its therapeutic potential for a wide range of fungal infections. In this study, our aim was to determine the in vivo efficacy of terbinafine and itraconazole on a experimental model of systemic sporotrichosis. 120 rats Wistar received an injection of 2x103 S. schenckii cells by via the lateral tail vein. After 3 days the animals were treated with terbinafine (250mg/kg) and itraconazole (100 mg/kg) and their respective diluents. In our model, terbinafine and itraconazole were effective in reducing the number of clinical lesions and positive organ cultures. There was statistical difference between the groups treated with the antifungals in relation to the control groups (p<0,05) concerning the clinical alterations, anatomic-pathological findings and in the positive organ cultures of the agent, being that the treated animals resulted in the absence and/or reduction of all the evaluated parameters. As for the treatments, terbinafine showed similar or higher activity that itraconazole in the evaluation of the testicle alteration (p=0,0004), as well as in the positive organ cultures of microorganism from the organ (p=0,0142). With these results it is possible to conclude that the antifungals studied are effective in the treatment of experimental systemic sporotrichosis.
publishDate 2008
dc.date.none.fl_str_mv 2008
2012-10-18T19:04:17Z
2012-10-18T19:04:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv MEINERZ, Ana Raquel Mano et al. Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis. Brazilian Journal of Microbiology, v. 39, n. 4, p. 734-737, 2008. Disponível em: <http://www.scielo.br/pdf/bjm/v39n4/arq25.pdf>. Acesso em: 16 out. 2012
http://repositorio.furg.br/handle/1/2639
http://dx.doi.org/10.1590/S1517-83822008000400025
identifier_str_mv MEINERZ, Ana Raquel Mano et al. Efficacy of terbinafine and itraconazole on a experimental model of systemic sporothrichosis. Brazilian Journal of Microbiology, v. 39, n. 4, p. 734-737, 2008. Disponível em: <http://www.scielo.br/pdf/bjm/v39n4/arq25.pdf>. Acesso em: 16 out. 2012
url http://repositorio.furg.br/handle/1/2639
http://dx.doi.org/10.1590/S1517-83822008000400025
dc.language.iso.fl_str_mv eng
language eng
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instname:Universidade Federal do Rio Grande (FURG)
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instname_str Universidade Federal do Rio Grande (FURG)
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reponame_str Repositório Institucional da FURG (RI FURG)
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