Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/5529 http://dx.doi.org/10.1590/S1676-24442014000100008 |
Resumo: | Introduction: Renal cell carcinoma (RCC) is an aggressive disease worldwide. Objective: Study traditional prognostic factors associated with pathological reports and the novel markers survivin and B7-H1 by immunohistochemistry. Methods: In a reference hospital of Porto Alegre, Brazil, we conducted a cross-sectional study of RCC in patients who underwent radical nephrectomy between 2006 and 2009. We selected those who were diagnosed with the most common histologic subtypes: clear cell and papillary RCC. We retrospectively reviewed pathological data to determine traditional prognostic factors, like size, presence of coagulative necrosis, Fuhrman grade and tumor-nodemetastasis (TNM) system. Besides, we performed an immunohistochemistry (IHC) study with survivin and B7-H1. Results: Our sample had 98 cases, 90% of the cases were composed by clear cell histologic subtype, 73% were tumors classified as T1 and T2 in the TNM system, most were Fuhrman nuclear grade 2 or 3, and 70% were positive for necrosis. In relation to the new prognostic markers, we found 50 cases positive to survivin and 38 to B7-H1. In this investigation of traditional prognostic markers and new markers we observed that only necrosis was associated with positive results of biomarkers (p < 0.001). Conclusion: This finding confirms previous studies that necrosis is an important factor to consider in the prognosis of RCC. |
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Freitas, Alexandra Medeiros Souza deHartmann, Antonio AtalibioFreitas, Tiarajú Alves de2015-10-28T11:04:55Z2015-10-28T11:04:55Z2014FREITAS, Alexandra Medeiros Souza de; HARTMANN, Antonio Atalibio; FREITAS, Tiarajú Alves de. Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil. Jornal Brasileiro de Patologia e Medicina Laboratorial, Rio de Janeiro , v. 50, n. 1, p. 57-63, 2014. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000100057&lng=en&nrm=iso>. Acesso em: 28 out. 2015.1676-2444http://repositorio.furg.br/handle/1/5529http://dx.doi.org/10.1590/S1676-24442014000100008Introduction: Renal cell carcinoma (RCC) is an aggressive disease worldwide. Objective: Study traditional prognostic factors associated with pathological reports and the novel markers survivin and B7-H1 by immunohistochemistry. Methods: In a reference hospital of Porto Alegre, Brazil, we conducted a cross-sectional study of RCC in patients who underwent radical nephrectomy between 2006 and 2009. We selected those who were diagnosed with the most common histologic subtypes: clear cell and papillary RCC. We retrospectively reviewed pathological data to determine traditional prognostic factors, like size, presence of coagulative necrosis, Fuhrman grade and tumor-nodemetastasis (TNM) system. Besides, we performed an immunohistochemistry (IHC) study with survivin and B7-H1. Results: Our sample had 98 cases, 90% of the cases were composed by clear cell histologic subtype, 73% were tumors classified as T1 and T2 in the TNM system, most were Fuhrman nuclear grade 2 or 3, and 70% were positive for necrosis. In relation to the new prognostic markers, we found 50 cases positive to survivin and 38 to B7-H1. In this investigation of traditional prognostic markers and new markers we observed that only necrosis was associated with positive results of biomarkers (p < 0.001). Conclusion: This finding confirms previous studies that necrosis is an important factor to consider in the prognosis of RCC.Introdução: O carcinoma de células renais (CCR) é uma doença de comportamento agressivo em todo o mundo. Objetivo: Estudar os fatores prognósticos tradicionais identificados no exame anatomopatológico e sua correlação com a expressão imunoistoquímica dos novos marcadores survivina e B7-H1. Materiais e métodos: Em um hospital de referência de Porto Alegre, foi realizado um estudo transversal de CCR, com pacientes que realizaram nefrectomia total, no período de 2006 a 2009. Foram selecionados aqueles com os tipos histológicos mais comuns: células claras e papilares. Fatores prognósticos tradicionais foram obtidos por meio da revisão de dados patológicos relevantes dos casos, como tamanho, necrose, tipo histológico, grau nuclear e sistema tumor-linfonodo-metástase (TNM). Também se realizou estudo imunoistoquímico (IMQ) da amostra, com o uso dos marcadores survivina e B7-H1. Resultados: Obtivemos 98 casos, com 90% deles do tipo células claras, 73% classificados como T1 e T2, a maioria com grau nuclear de Fuhrman 2 e 3 e cerca de 70% da amostra positivos para necrose. Já no estudo IMQ foi encontrada positividade em 38 casos para o B7-H1 e em 50 para survivina. Ao considerarmos a associação entre os fatores prognósticos tradicionais e a expressão dos marcadores, encontramos associação somente entre o grupo positivo para os marcadores e necrose (p < 0,001). Conclusão: Tal achado vai ao encontro dos dados da literatura que vêm realçando a importância da necrose no prognóstico dos CCR.engRenal carcinomaTumor markersB7-H1SurvivinImmunohistochemistryPrognostic factorsCarcinoma renalMarcadores tumoraisSurvivinaImunoistoquímicaFatores prognósticosRenal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, BrazilTumores renais: avaliação de fatores prognósticos de 98 casos em hospital de referência de Porto Alegre, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALRenal tumors evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil.pdfRenal tumors evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil.pdfapplication/pdf237434https://repositorio.furg.br/bitstream/1/5529/1/Renal%20tumors%20evaluation%20of%20prognostic%20factors%20in%2098%20cases%20from%20a%20reference%20hospital%20in%20Porto%20Alegre%2c%20Brazil.pdf5b27a45dd02c36b78dc336f76b31e8a7MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/5529/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/55292022-10-25 16:38:56.03open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2022-10-25T19:38:56Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Tumores renais: avaliação de fatores prognósticos de 98 casos em hospital de referência de Porto Alegre, Brasil |
title |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil |
spellingShingle |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil Freitas, Alexandra Medeiros Souza de Renal carcinoma Tumor markers B7-H1 Survivin Immunohistochemistry Prognostic factors Carcinoma renal Marcadores tumorais Survivina Imunoistoquímica Fatores prognósticos |
title_short |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil |
title_full |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil |
title_fullStr |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil |
title_full_unstemmed |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil |
title_sort |
Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil |
author |
Freitas, Alexandra Medeiros Souza de |
author_facet |
Freitas, Alexandra Medeiros Souza de Hartmann, Antonio Atalibio Freitas, Tiarajú Alves de |
author_role |
author |
author2 |
Hartmann, Antonio Atalibio Freitas, Tiarajú Alves de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Freitas, Alexandra Medeiros Souza de Hartmann, Antonio Atalibio Freitas, Tiarajú Alves de |
dc.subject.por.fl_str_mv |
Renal carcinoma Tumor markers B7-H1 Survivin Immunohistochemistry Prognostic factors Carcinoma renal Marcadores tumorais Survivina Imunoistoquímica Fatores prognósticos |
topic |
Renal carcinoma Tumor markers B7-H1 Survivin Immunohistochemistry Prognostic factors Carcinoma renal Marcadores tumorais Survivina Imunoistoquímica Fatores prognósticos |
description |
Introduction: Renal cell carcinoma (RCC) is an aggressive disease worldwide. Objective: Study traditional prognostic factors associated with pathological reports and the novel markers survivin and B7-H1 by immunohistochemistry. Methods: In a reference hospital of Porto Alegre, Brazil, we conducted a cross-sectional study of RCC in patients who underwent radical nephrectomy between 2006 and 2009. We selected those who were diagnosed with the most common histologic subtypes: clear cell and papillary RCC. We retrospectively reviewed pathological data to determine traditional prognostic factors, like size, presence of coagulative necrosis, Fuhrman grade and tumor-nodemetastasis (TNM) system. Besides, we performed an immunohistochemistry (IHC) study with survivin and B7-H1. Results: Our sample had 98 cases, 90% of the cases were composed by clear cell histologic subtype, 73% were tumors classified as T1 and T2 in the TNM system, most were Fuhrman nuclear grade 2 or 3, and 70% were positive for necrosis. In relation to the new prognostic markers, we found 50 cases positive to survivin and 38 to B7-H1. In this investigation of traditional prognostic markers and new markers we observed that only necrosis was associated with positive results of biomarkers (p < 0.001). Conclusion: This finding confirms previous studies that necrosis is an important factor to consider in the prognosis of RCC. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-10-28T11:04:55Z |
dc.date.available.fl_str_mv |
2015-10-28T11:04:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FREITAS, Alexandra Medeiros Souza de; HARTMANN, Antonio Atalibio; FREITAS, Tiarajú Alves de. Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil. Jornal Brasileiro de Patologia e Medicina Laboratorial, Rio de Janeiro , v. 50, n. 1, p. 57-63, 2014. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000100057&lng=en&nrm=iso>. Acesso em: 28 out. 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/5529 |
dc.identifier.issn.none.fl_str_mv |
1676-2444 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1590/S1676-24442014000100008 |
identifier_str_mv |
FREITAS, Alexandra Medeiros Souza de; HARTMANN, Antonio Atalibio; FREITAS, Tiarajú Alves de. Renal tumors: evaluation of prognostic factors in 98 cases from a reference hospital in Porto Alegre, Brazil. Jornal Brasileiro de Patologia e Medicina Laboratorial, Rio de Janeiro , v. 50, n. 1, p. 57-63, 2014. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000100057&lng=en&nrm=iso>. Acesso em: 28 out. 2015. 1676-2444 |
url |
http://repositorio.furg.br/handle/1/5529 http://dx.doi.org/10.1590/S1676-24442014000100008 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
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Repositório Institucional da FURG (RI FURG) |
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